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J Cell Biol 2000 Aug 07;1503:499-512. doi: 10.1083/jcb.150.3.499.
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A kinesin-related protein, KRP(180), positions prometaphase spindle poles during early sea urchin embryonic cell division.

Rogers GC , Chui KK , Lee EW , Wedaman KP , Sharp DJ , Holland G , Morris RL , Scholey JM .

We have investigated the intracellular roles of an Xklp2-related kinesin motor, KRP(180), in positioning spindle poles during early sea urchin embryonic cell division using quantitative, real-time analysis. Immunolocalization reveals that KRP(180) concentrates on microtubules in the central spindle, but is absent from centrosomes. Microinjection of inhibitory antibodies and dominant negative constructs suggest that KRP(180) is not required for the initial separation of spindle poles, but instead functions to transiently position spindle poles specifically during prometaphase.

PubMed ID: 10931863
PMC ID: PMC2175202
Article link: J Cell Biol
Grant support: [+]

Species referenced: Echinodermata
Genes referenced: dnah3 kif11 kif15 kif23 LOC100887844 LOC115919910 LOC373208 LOC594261 LOC594349 pole tubgcp2
Antibodies: LOC373238 Ab1 LOC590586 Ab11 kif15 Ab1

Article Images: [+] show captions
References [+] :
Boleti, Xklp2, a novel Xenopus centrosomal kinesin-like protein required for centrosome separation during mitosis. 1996, Pubmed