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ECB-ART-35490
J Nat Prod 1981 Jan 01;446:701-4. doi: 10.1021/np50018a015.
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Antineoplastic agents. 76. The sea urchin Strongylocentrotus droebachiensis.

Pettit GR , Hasler JA , Paull KD , Herald CL .


Abstract
An improved procedure based on centrifugation at 37,000 g has been developed for isolating the antineoplastic glycoprotein strongylostatin 1 from Strongylocentrotus droebachiensis (Müller). The green sea urchin has also been found to contain a second protein anticancer constituent designated strongylostatin 2. Treatment of the murine P388 lymphocytic leukemia with strongylostatin 2 resulted in 39-42% life extension at a dose of 4.5 mg/kg.

PubMed ID: 7334385
Article link: J Nat Prod
Grant support: [+]

Genes referenced: LOC100887844 LOC591473