Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Echinobase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
J Nat Prod 1981 Jan 01;446:701-4. doi: 10.1021/np50018a015.
Show Gene links Show Anatomy links

Antineoplastic agents. 76. The sea urchin Strongylocentrotus droebachiensis.

Pettit GR , Hasler JA , Paull KD , Herald CL .

An improved procedure based on centrifugation at 37,000 g has been developed for isolating the antineoplastic glycoprotein strongylostatin 1 from Strongylocentrotus droebachiensis (Müller). The green sea urchin has also been found to contain a second protein anticancer constituent designated strongylostatin 2. Treatment of the murine P388 lymphocytic leukemia with strongylostatin 2 resulted in 39-42% life extension at a dose of 4.5 mg/kg.

PubMed ID: 7334385
Article link: J Nat Prod
Grant support: [+]

Genes referenced: LOC100887844 LOC591473