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Dev Biol 1991 Oct 01;1472:445-50. doi: 10.1016/0012-1606(91)90302-j.
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Altered cell fate in LiCl-treated sea urchin embryos.

Nocente-McGrath C , McIsaac R , Ernst SG .

Endo16 is a lineage-specific protein expressed during embryogenesis in the sea urchin, Strongylocentrotus purpuratus. We have examined the effects of various concentrations of lithium chloride, a well-known vegetalizing agent, on Endo16 expression in whole sea urchin embryos. Our results show that treatment with LiCl causes increased steady-state levels of Endo16 transcripts. An increase in the number of endodermal cells in treated embryos demonstrates a change in cell lineage. In addition, we observed a delay in development of lithium-treated embryos that is accompanied by a delay in the expression of a late class histone H2B gene.

PubMed ID: 1717326
Article link: Dev Biol

Genes referenced: endo16 LOC100887844 LOC115919910 LOC115926321
Antibodies: endo16 Ab1