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ECB-ART-55274
J Taibah Univ Med Sci 2026 Aug 07;214:735-745. doi: 10.1016/j.jtumed.2026.06.009.
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Determining the concentration of golden sea cucumber (Stichopus her r manni) extract gel in oral traumatic ulcers.

Soesilawati P, Yuliati , Damaiyanti DW, Firdauzy MAB, Panggabean MSC, Ramadhan M, Larasati AR, Arundina I, Dewiyanti CN, Gerrard R, Prasetyo EN, Ahmad N.


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OBJECTIVE: Traumatic oral ulcers are common lesions that may interfere with oral function and quality of life. Golden sea cucumber (Stichopus her r manni) contains various bioactive compounds with potential wound healing properties. This study aimed to evaluate the effects of different concentrations of golden sea cucumber extract gel on traumatic oral ulcer healing in Wistar rats. METHODS: Twenty male Wistar rats were randomly divided into four groups: control, 20%, 40%, and 80% golden sea cucumber extract gel groups. Traumatic ulcers were induced on the lower labial mucosa using a heated burnisher. The treatment groups received topical application of the extract gel once daily. Histopathological evaluations were performed on days 4 and 7 post-ulcer induction. The observed parameters included macrophage count, mast cell count, angiogenesis, collagen density, and re-epithelialization. Statistical analysis was performed using one-way ANOVA followed by Tukey's post hoc test, with p < 0.05 considered statistically significant. RESULTS: The 40% concentration group demonstrated higher angiogenesis compared with the other groups during the early healing phase. Meanwhile, the 80% concentration group showed greater macrophages, epithelial thickness, and collagen density during the proliferative phase. Significant differences were observed among treatment groups in several histological parameters (p < 0.05), indicating enhanced wound healing activity following golden sea cucumber extract administration. CONCLUSION: Stichopus her r manni extract gel accelerated traumatic oral ulcer healing by modulating inflammation, promoting angiogenesis, enhancing re-epithelialization, and increasing collagen deposition. Different concentrations exhibited distinct therapeutic effects at different stages of oral wound healing, suggesting its potential as a natural adjunctive therapy for traumatic oral ulcers.

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