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ECB-ART-54671
Nat Prod Res 2026 Jan 23;:1-11. doi: 10.1080/14786419.2026.2619416.
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1,2-Cyclic acetal-type glycerophospholipids from the arctic starfish Asterias microdiscus.

Kicha AA, Santalova EA, Malyarenko TV, Kalinovsky AI, Popov RS, Yurchenko EA, Stonik VA, Ivanchina NV.


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Unusual 1,2-cyclic acetal-type glycero-3-phosphoethanolamines, isolated from the EtOH extract of the Arctic starfish Asterias -microdiscus (Chukchi Sea), were analysed as constituents of a RP-HPLC fraction using extensive NMR, MS techniques, and chemical transformations. Four new ethanolamine glycerophospholipids were found to differ from each other in the positions of - CH = CH - CH(OOH/OH)- moieties in linear acetal-linked C20 chains. The mixture of these compounds showed cardioprotective activity against CoCl2-induced damage of H9c2 cardiomyocytes via partial restoration of mitochondrial membrane potential.

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