Indian J Ophthalmol 2026 Jan 07; doi: 10.4103/IJO.IJO_1812_25.

Optical coherence tomography angiography features of inflammatory choroidal neovascularizaton in Vogt-Koyanagi-Harada disease.

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PURPOSE: To describe optical coherence tomography angiography (OCTA) features of inflammatory choroidal neovascular membrane (iCNV) in Vogt-Koyanagi-Harada (VKH) disease. METHODS: This is a retrospective review of the medical records of patients with iCNV in VKH disease, documented on OCTA, seen by a single uveitis specialist from a tertiary care eye hospital. Each patient had a detailed medical record of the clinical features and underwent swept-source OCTA (SS-OCTA) analyzed by a retina specialist and a uveitis specialist. RESULTS: Analysis of the 11 eyes of 8 patients who had iCNV and SS-OCTA documentation showed that peripapillary iCNV was the most common. Distinct iCNV patterns noted were filamentous, sea fan, medusa head, and pruned along with flow voids of choroidal granulomas in the active inflammatory stage of the disease. Reduction of the flow signals in iCNV, on OCTA, indicated a response to treatment. CONCLUSION: OCTA is a valuable tool in visualization and classification of choroidal neovascularizations and their response to treatment in inflammatory conditions like VKH disease.

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