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ECB-ART-54486
Antimicrob Agents Chemother 2025 Nov 18;:e0070725. doi: 10.1128/aac.00707-25.
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ISAba1-mediated blaADC disruption restores third-generation cephalosporin susceptibility in a clinical Acinetobacter baumannii isolate.

Nodari CS , Bai Q , Cayô R , Streling AP , Alberto-Lei F , Wille J , C Pignatari AC , Seifert H , Gales AC , Higgins PG .


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This study describes the effects of the insertion of ISAba1 in the intrinsic blaADC gene of an Acinetobacter baumannii isolate showing co-resistance to carbapenems and colistin. Isolate 52971 showed low ceftazidime MIC values due to the disruption of blaADC-195 by this insertion sequence. The introduction of an intact blaADC in isolate 52971 increased ceftazidime MIC. The potential of insertion sequences to inactivate chromosome-encoded resistance determinants should be explored.

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