Food Chem X 2025 Oct 24;31:103190. doi: 10.1016/j.fochx.2025.103190.

Whole genome sequencing and metabonomics analysis reveal the biodegradation process of deoxynivalenol in a safety Bacillus velezensis T-3 isolated from the gut of sea cucumber.

???displayArticle.abstract???
Deoxynivalenol (DON) is a typical mycotoxin mainly produced by Fusarium, which seriously endangers the safety of global agriculture, feed and food. To further explore the biodegradation strategy of DON, a safety Bacillus velezensis T-3 was identified. The biodegradration process of DON by B. velezensis T-3 was further revealed via target fermentation and metabonomics analysis. Results showed that B. velezensis T-3 could effectively antagonize the growth of mycotoxin-producing Fusarium graminearum, Penicillium chrysogenum and Aspergillus flavus. Moreover, metabonomics analysis indicated that DON could be completely removed by B. velezensis T-3 within 72 h. Further analysis found that DON could be converted into low-toxic or non-toxic compounds such as retinoic acid, glycine, etc. In application stage, the highest degradation rate of DON in corn by-products was 49.59%, B. velezensis T-3 could also effectively inhibit the growth of molds to prolong the mildew cycle of corn by-products, thus remarkably reducing the harmfulness of DON.

???displayArticle.pubmedLink??? 41245106
???displayArticle.link??? Food Chem X