Int J Biol Macromol 2025 Sep 12;:147601. doi: 10.1016/j.ijbiomac.2025.147601.

Unraveling the mysteries of polysaccharides from the genus Padina: Their preparation, structural characterization, and bioactivities-A review.

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The genus Padina, belonging to the family Dictyotaceae, is extensively distributed across tropical and subtropical coastal regions. Characterized by its distinctive fan-shaped morphology, Padina features a flattened and ruffled thallus structure, which has led to its common designation as "sea-fan ribbon weed". As a low-calorie, nutrient-rich marine vegetable, Padina is frequently consumed in the daily diets of coastal communities. In addition to its notable nutritional value, Padina exhibits significant medicinal potential. Polysaccharides stand as the pivotal bioactive constituents in Padina, and a growing body of research has demonstrated that the genus Padina polysaccharides (TGPPs) possess various biological activities, such as anti-tumor, anti-oxidant, immunomodulatory, anti-viral, anti-obesity, and cardioprotective effects. However, current research on TGPPs has not been comprehensively summarized, restricting their further exploration and application development. Therefore, to enhance understanding of these components, this review systematically examines the research progress on TGPPs, including extraction methods, isolation and purification techniques, structural characteristics, and various biological activities. Furthermore, it points out the limitations in existing research and suggests future research directions, offering theoretical support and references for the potential applications of TGPPs in the food, pharmaceutical, cosmetic, aquaculture, and agricultural industries.

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