Int J Biol Macromol 2025 May 05;311Pt 3:143906. doi: 10.1016/j.ijbiomac.2025.143906.

Type 3 resistant starch prepared from euryale ferox alleviated the obesity symptoms via gut microbiota regulation.

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The type 3 resistant starch (RS3) was obtained from euryale ferox through enzymolysis-autoclaving. The effects of euryale ferox RS3 (ERS) on the body weight, lipid metabolism, inflammatory response, and gut microbiota composition of golden hamsters administered a high-fat diet were determined to assess the potential role of ERS in inhibiting obesity. The purified ERS was in the B + V-type crystal form, which has a great anti-enzymatic structure. Additionally, ERS may promote the growth of beneficial gut microbiota including norank_f_Muribaculaceae and Ruminococcus, while it can inhibit the growth of the gut microbiota including Allobaculum, thus alleviating symptoms of weight gain, fat accumulation, oxidative stress, chronic low-grade inflammation, and liver injury. The above findings laid a theoretical foundation for the application of ERS in specific foods to prevent obesity.

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