Food Res Int 2025 May 28;208:116085. doi: 10.1016/j.foodres.2025.116085.

EPA-enriched lipid from Apostichopus japonicus byproducts mitigates UVB-induced oxidative stress and inflammation by gut-skin axis.

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The tremendous byproducts from sea cucumber processing discarded as waste bring serious environmental and economic challenges. The abundant EPA in sea cucumber intestines indicates the potential for lipid development. However, there is little study on how these lipids affect skin health. Using REM techniques, this study prepared lipids from Apostichopus japonicus intestines (AJIL) with a 26.63 % EPA content, which displayed DPPH scavenging capacity in vitro. Administration of AJIL showed significant skin repair effects by reducing the symptoms of UVB-induced skin tissue damage, preventing epidermal thickening and increasing hydroxyproline content to protect collagen. AJIL suppressed oxidative stress and inflammation by significantly reducing ROS and MDA levels and enhancing GPx and CAT activity, as well as inhibiting the expression of inflammatory cytokines such as TNF-α, NF-κB, IL-1β and IL-6. By upregulating Nrf2, HO-1 and NQO-1 and downregulating Keap1, AJIL activated the Keap1-Nrf2 signaling pathways. Furthermore, AJIL regulated the composition and structure of gut microbiome, especially significantly increasing the SCFA-producing and anti-inflammatory bacteria like Muribacuclaceae, Alloprevotella, Bacteroides and Prevotellaceae, then improved key metabolic pathways. Overall, AJIL mediated the gut-skin axis to prevent UVB-induced skin damage and revealed potential as a natural skin protection candidate, which transformed discarded sea cucumber intestines into valuable resources for skin health.

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