ECB-ART-53099
Nat Prod Res
2024 May 11;:1-7. doi: 10.1080/14786419.2024.2350639.
Show Gene links
Show Anatomy links
Polyhydroxy steroids isolated from starfish (Asterina pectinifera) and their embryotoxicity.
???displayArticle.abstract???
Many marine organisms possess an essential capacity to produce secondary metabolites that exhibit toxic characteristics. A new polyhydroxy steroid, 24-methyl-5α-cholestane-24(28)-ene-3β, 4β, 6α, 7α, 8, 15β, 16β, 26-octol-6-O-sodium sulphate (1) was isolated from starfish (Asterina pectinifera), along with five polar steroid compounds (2-6) that were previously identified. NMR (1H and 13C NMR, 1H-1H COSY, HSQC, HMBC, and NOESY) and HR-ESI-MS were employed for structure elucidations. The embryotoxicity and teratogenicity of the isolated compounds were assessed using embryos of marine medaka (Oryzias melastigma). Compound 5 exhibited moderate embryotoxicity (96h-LC50: 65 μM).
???displayArticle.pubmedLink??? 38733627
???displayArticle.link??? Nat Prod Res