Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Echinobase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
Echinobase
ECB-ART-53086
J Nat Prod 2024 Apr 17; doi: 10.1021/acs.jnatprod.3c01191.
Show Gene links Show Anatomy links

Pleonotoquinones, Cytotoxic Oxepinenaphthoquinones from Pleonotoma jasminifolia.

Anselmo LT , de Souza TA , Brito TAM , Peres EG , da Silva FMA , Silva VR , Santos LS , Soares MBP , Bezerra DP , Costa EV , Sipoloni VM , de Medeiros LS , da Silva MS , Tavares JF , Gomes WR , Koolen HHF .


???displayArticle.abstract???
Two unusual naphthoquinones, named here as pleonotoquinones A (1) and B (2), were isolated along with two known anthraquinones (3 and 4) via chromatographic separations of an ethyl acetate extract of the roots of Pleonotoma jasminifolia. Compounds 1 and 2 are the first examples of quinones bearing a 2-methyloxepine moiety. The compounds were isolated with the aid of mass spectrometry and molecular networking, and their structures were resolved using 1D and 2D NMR and HRESIMS data. The isolated compounds were evaluated for their antiproliferative activity against human cancer cell lines, and compounds 1 and 2 displayed cytotoxicity against human colon cancer HCT116 cells (IC50 = 2.6 μM for compound 1 and IC50 = 4.3 μM for compound 2) and human liver cancer HepG2 cells (IC50 = 1.9 μM for compound 1 and IC50 = 6.4 μM for compound 2).

???displayArticle.pubmedLink??? 38630559
???displayArticle.link??? J Nat Prod