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Front Oncol
2023 Jan 01;13:1307838. doi: 10.3389/fonc.2023.1307838.
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Anti-tumor target screening of sea cucumber saponin Frondoside A: a bioinformatics and molecular docking analysis.
Liu G
,
Zhang S
,
Lin R
,
Cao X
,
Yuan L
.
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Cancer remains the leading cause of death worldwide. In spite of significant advances in targeted and immunotherapeutic approaches, clinical outcomes for cancer remain poor. The aim of the present study was to investigate the potential mechanisms and therapeutic targets of Frondoside A for the treatment of liver, pancreatic, and bladder cancers. The data presented in our study demonstrated that Frondoside A reduced the viability and migration of HepG2, Panc02, and UM-UC-3 cancer cell in vitro. Moreover, we utilized the GEO database to screen and identify for differentially expressed genes (DEGs) in liver, pancreatic, and bladder cancers, which resulted in the identification of 714, 357, and 101 DEGs, respectively. Gene Ontology (GO) analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway annotation were performed using the Metascape database for DEGs that were significantly associated with cancer development. The protein-protein interaction (PPI) networks of the identified DEGs in liver, pancreatic, and bladder cancers were analyzed using Cytoscape 3.9.0 software, and subsequently identified potential key genes that were associated with these networks. Subsequently, their prognostic values were assessed by gene expression level analysis and Kaplan-Meier survival analysis (GEPIA). Furthermore, we utilized TIMER 2.0 to investigate the correlation between the expression of the identified key gene and cancer immune infiltration. Finally, molecular docking simulations were performed to assess the affinity of Frondoside A and key genes. Our results showed a significant correlation between these DEGs and cancer progression. Combined, these analyses revealed that Frondoside A involves in the regulation of multiple pathways, such as drug metabolism, cell cycle in liver cancer by inhibiting the expression of CDK1, TOP2A, CDC20, and KIF20A, and regulates protein digestion and absorption, receptor interaction in pancreatic cancer by down-regulation of ASPM, TOP2A, DLGAP5, TPX2, KIF23, MELK, LAMA3, and ANLN. While in bladder cancer, Frondoside A regulates muscle contraction, complement and coagulation cascade by increase FLNC expression. In conclusion, the present study offers valuable insights into the molecular mechanism underlying the anticancer effects of Frondoside A, and suggests that Frondoside A can be used as a functional food supplement or further developed as a natural anti-cancer drug.
Adrian,
The Anti-Cancer Effects of Frondoside A.
2018, Pubmed,
Echinobase
Adrian,
The Anti-Cancer Effects of Frondoside A.
2018,
Pubmed
,
Echinobase
Agarwal,
Gene expression profiling, pathway analysis and subtype classification reveal molecular heterogeneity in hepatocellular carcinoma and suggest subtype specific therapeutic targets.
2017,
Pubmed
Al Shemaili,
Pharmacokinetics in Mouse and Comparative Effects of Frondosides in Pancreatic Cancer.
2016,
Pubmed
,
Echinobase
Ang,
In vivo antimalarial activity of the beta-carboline alkaloid manzamine A.
2000,
Pubmed
Badr,
The Role of LINC01564, RAMS11, CBX4 and TOP2A in Hepatocellular Carcinoma.
2022,
Pubmed
Bassal,
Characterization of a novel human cell-cycle-regulated homologue of Drosophila dlg1.
2001,
Pubmed
Baugh,
Real-time PyMOL visualization for Rosetta and PyRosetta.
2011,
Pubmed
Brown,
CDK1 structures reveal conserved and unique features of the essential cell cycle CDK.
2015,
Pubmed
Burley,
RCSB Protein Data Bank: powerful new tools for exploring 3D structures of biological macromolecules for basic and applied research and education in fundamental biology, biomedicine, biotechnology, bioengineering and energy sciences.
2021,
Pubmed
Chereau,
Leiomodin is an actin filament nucleator in muscle cells.
2008,
Pubmed
Chhatriya,
Transcriptome analysis identifies putative multi-gene signature distinguishing benign and malignant pancreatic head mass.
2020,
Pubmed
Chung,
Maternal embryonic leucine zipper kinase regulates pancreatic ductal, but not β-cell, regeneration.
2014,
Pubmed
Conley,
Leiomodin and tropomodulin in smooth muscle.
2001,
Pubmed
Correia-da-Silva,
Anticancer and cancer preventive compounds from edible marine organisms.
2017,
Pubmed
,
Echinobase
Dasari,
Cisplatin in cancer therapy: molecular mechanisms of action.
2014,
Pubmed
Drozdov,
Functional and topological properties in hepatocellular carcinoma transcriptome.
2012,
Pubmed
Du,
Propofol modulates the proliferation, invasion and migration of bladder cancer cells through the miR‑145‑5p/TOP2A axis.
2021,
Pubmed
Duffy,
Use of Biomarkers in Screening for Cancer.
2015,
Pubmed
Dyshlovoy,
Frondoside A induces AIF-associated caspase-independent apoptosis in Burkitt lymphoma cells.
2017,
Pubmed
Dyshlovoy,
The marine triterpene glycoside frondoside A exhibits activity in vitro and in vivo in prostate cancer.
2016,
Pubmed
Dyshlovoy,
The marine triterpene glycoside frondoside A induces p53-independent apoptosis and inhibits autophagy in urothelial carcinoma cells.
2017,
Pubmed
,
Echinobase
Edgar,
Gene Expression Omnibus: NCBI gene expression and hybridization array data repository.
2002,
Pubmed
Fagerberg,
Analysis of the human tissue-specific expression by genome-wide integration of transcriptomics and antibody-based proteomics.
2014,
Pubmed
Frank,
Cardiac α-Actin (ACTC1) Gene Mutation Causes Atrial-Septal Defects Associated With Late-Onset Dilated Cardiomyopathy.
2019,
Pubmed
Gaillard,
Evaluation of AutoDock and AutoDock Vina on the CASF-2013 Benchmark.
2018,
Pubmed
Ganguly,
MELK-a conserved kinase: functions, signaling, cancer, and controversy.
2015,
Pubmed
Gao,
KIF23 enhances cell proliferation in pancreatic ductal adenocarcinoma and is a potent therapeutic target.
2020,
Pubmed
Gasnereau,
KIF20A mRNA and its product MKlp2 are increased during hepatocyte proliferation and hepatocarcinogenesis.
2012,
Pubmed
Gomes-Filho,
Aurora A kinase and its activator TPX2 are potential therapeutic targets in KRAS-induced pancreatic cancer.
2020,
Pubmed
Haque,
Marine Natural Products in Clinical Use.
2022,
Pubmed
Hou,
A structural basis for Lowe syndrome caused by mutations in the Rab-binding domain of OCRL1.
2011,
Pubmed
Hsu,
The differential distributions of ASPM isoforms and their roles in Wnt signaling, cell cycle progression, and pancreatic cancer prognosis.
2019,
Pubmed
Huang,
MELK is not necessary for the proliferation of basal-like breast cancer cells.
2017,
Pubmed
Idichi,
Regulation of actin-binding protein ANLN by antitumor miR-217 inhibits cancer cell aggressiveness in pancreatic ductal adenocarcinoma.
2017,
Pubmed
Janakiram,
Sea Cucumbers Metabolites as Potent Anti-Cancer Agents.
2015,
Pubmed
,
Echinobase
Jiang,
To construct a ceRNA regulatory network as prognostic biomarkers for bladder cancer.
2020,
Pubmed
Kakar,
Identification of Differentially Expressed Genes Associated with the Prognosis and Diagnosis of Hepatocellular Carcinoma by Integrated Bioinformatics Analysis.
2022,
Pubmed
Ke,
Bioinformatics analysis combined with experiments to explore potential prognostic factors for pancreatic cancer.
2020,
Pubmed
Khalifa,
Marine Natural Products: A Source of Novel Anticancer Drugs.
2019,
Pubmed
Kim,
Identification of key genes and carcinogenic pathways in hepatitis B virus-associated hepatocellular carcinoma through bioinformatics analysis.
2022,
Pubmed
Kisling,
Implications of prognosis-associated genes in pancreatic tumor metastasis: lessons from global studies in bioinformatics.
2021,
Pubmed
Lambert,
Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.
2019,
Pubmed
Lee,
Sensitivity to BUB1B Inhibition Defines an Alternative Classification of Glioblastoma.
2017,
Pubmed
Li,
TIMER2.0 for analysis of tumor-infiltrating immune cells.
2020,
Pubmed
Li,
Increased CDC20 expression is associated with development and progression of hepatocellular carcinoma.
2014,
Pubmed
Lin,
Substrate-specific activation of the mitotic kinase Bub1 through intramolecular autophosphorylation and kinetochore targeting.
2014,
Pubmed
Liu,
CALD1, CNN1, and TAGLN identified as potential prognostic molecular markers of bladder cancer by bioinformatics analysis.
2019,
Pubmed
Ma,
The FOXM1/BUB1B signaling pathway is essential for the tumorigenicity and radioresistance of glioblastoma.
2017,
Pubmed
Makyio,
Structural basis for Arf6-MKLP1 complex formation on the Flemming body responsible for cytokinesis.
2012,
Pubmed
Miserey-Lenkei,
Coupling fission and exit of RAB6 vesicles at Golgi hotspots through kinesin-myosin interactions.
2017,
Pubmed
Nair,
Application of comprehensive bioinformatics approaches to reconnoiter crucial genes and pathways underpinning hepatocellular carcinoma: a drug repurposing endeavor.
2021,
Pubmed
Nobili,
Natural compounds for cancer treatment and prevention.
2009,
Pubmed
Ohtaki,
ACTC1 as an invasion and prognosis marker in glioma.
2017,
Pubmed
Pangestuti,
Medicinal and health benefit effects of functional sea cucumbers.
2018,
Pubmed
,
Echinobase
Pashaei,
A Meta-Analysis: Identification of Common Mir-145 Target Genes that have Similar Behavior in Different GEO Datasets.
2016,
Pubmed
Passaia,
TCF21/POD-1, a Transcritional Regulator of SF-1/NR5A1, as a Potential Prognosis Marker in Adult and Pediatric Adrenocortical Tumors.
2018,
Pubmed
Pathak,
Cancer Chemotherapy via Natural Bioactive Compounds.
2022,
Pubmed
Pei,
TOP2A induces malignant character of pancreatic cancer through activating β-catenin signaling pathway.
2018,
Pubmed
Raemaekers,
NuSAP, a novel microtubule-associated protein involved in mitotic spindle organization.
2003,
Pubmed
Rocha-Martin,
Emerging strategies and integrated systems microbiology technologies for biodiscovery of marine bioactive compounds.
2014,
Pubmed
Roche,
Establishment and Characterisation by Expression Microarray of Patient-Derived Xenograft Panel of Human Pancreatic Adenocarcinoma Patients.
2020,
Pubmed
Ru,
Sea Cucumber Derived Triterpenoid Glycoside Frondoside A: A Potential Anti-Bladder Cancer Drug.
2023,
Pubmed
,
Echinobase
Sulaiman,
Butein and Frondoside-A Combination Exhibits Additive Anti-Cancer Effects on Tumor Cell Viability, Colony Growth, and Invasion and Synergism on Endothelial Cell Migration.
2021,
Pubmed
Sung,
Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries.
2021,
Pubmed
Szklarczyk,
The STRING database in 2021: customizable protein-protein networks, and functional characterization of user-uploaded gene/measurement sets.
2021,
Pubmed
Tan,
LMOD1, an oncogene associated with Lauren classification, regulates the metastasis of gastric cancer cells through the FAK-AKT/mTOR pathway.
2022,
Pubmed
Tanaka,
Molecular Pathogenesis of Pancreatic Ductal Adenocarcinoma: Impact of miR-30c-5p and miR-30c-2-3p Regulation on Oncogenic Genes.
2020,
Pubmed
Tang,
GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses.
2017,
Pubmed
Tímár,
On-Target Side Effects of Targeted Therapeutics of Cancer.
2022,
Pubmed
Wang,
ANLN-induced EZH2 upregulation promotes pancreatic cancer progression by mediating miR-218-5p/LASP1 signaling axis.
2019,
Pubmed
Wanibuchi,
Actin, alpha, cardiac muscle 1 (ACTC1) knockdown inhibits the migration of glioblastoma cells in vitro.
2018,
Pubmed
Wargasetia,
Mechanisms of cancer cell killing by sea cucumber-derived compounds.
2017,
Pubmed
,
Echinobase
Xia,
Cancer statistics in China and United States, 2022: profiles, trends, and determinants.
2022,
Pubmed
Xue,
Frondoside A Inhibits an MYC-Driven Medulloblastoma Model Derived from Human-Induced Pluripotent Stem Cells.
2021,
Pubmed
Yang,
KNTC1 knockdown inhibits proliferation and metastases of liver cancer.
2023,
Pubmed
Yao,
Identification and verification of effective components of Huanghuai for dysfunctional uterine bleeding based on network pharmacology and molecular docking.
2021,
Pubmed
Zaravinos,
Identification of common differentially expressed genes in urinary bladder cancer.
2011,
Pubmed
Zhang,
Proliferation and invasion of colon cancer cells are suppressed by knockdown of TOP2A.
2018,
Pubmed
Zhang,
CNN1 Represses Bladder Cancer Progression and Metabolic Reprogramming by Modulating HIF-1α Signaling Pathway.
2022,
Pubmed
Zhao,
CDC20 regulates the cell proliferation and radiosensitivity of P53 mutant HCC cells through the Bcl-2/Bax pathway.
2021,
Pubmed
Zhao,
The role of CDK1 in apoptin-induced apoptosis in hepatocellular carcinoma cells.
2013,
Pubmed
Zhou,
Metascape provides a biologist-oriented resource for the analysis of systems-level datasets.
2019,
Pubmed
Zhou,
Metformin induces miR-378 to downregulate the CDK1, leading to suppression of cell proliferation in hepatocellular carcinoma.
2018,
Pubmed
Zhu,
BUB1 promotes proliferation of liver cancer cells by activating SMAD2 phosphorylation.
2020,
Pubmed
Zorba,
Molecular mechanism of Aurora A kinase autophosphorylation and its allosteric activation by TPX2.
2014,
Pubmed
