Click
here to close Hello! We notice that
you are using Internet Explorer, which is not supported by Echinobase
and may cause the site to display incorrectly. We suggest using a
current version of Chrome,
FireFox,
or Safari.
Food Chem X
2023 Oct 30;19:100741. doi: 10.1016/j.fochx.2023.100741.
Show Gene links
Show Anatomy links
UPLC-Q-TOF/MS-based metabonomics reveals mechanisms for Holothuria leucospilota polysaccharides (HLP)-regulated serum metabolic changes in diabetic rats.
Zhang X
,
Zhao F
,
Ma T
,
Zheng Y
,
Cao J
,
Li C
,
Zhu K
.
???displayArticle.abstract???
This study aimed to use metabolomic methods to explore how Holothuria leucospilota polysaccharides (HLP) improved metabolism disorders in the liver of Goto-Kakizaki (GK) rats with spontaneous type 2 diabetes. The results showed that HLP effectively improved the metabolic disorder. Based on KEGG functional analysis, five key biomarkers associated with bile acid metabolism were detected and screened (P < 0.05). The results of serum total bile acid levels and liver damage in diabetic rats further showed the regulatory effects of HLP on bile acid metabolism. The results of bile acid-related gene expression in the liver showed that HLP inhibited liver farnesoid X Receptor - small heterodimer partner (FXR-SHP) signalling and increased the expression of bile acid synthesis genes (P < 0.05). Our results explored the underlying mechanisms by which HLP accelerated cholesterol consumption to anti-hypercholesterolemia and anti-diabetic by inhibiting liver FXR-SHP signaling. HLP's effect on bile acid regulation provides insights into treating T2DM.
Ahlin,
Bile acid changes after metabolic surgery are linked to improvement in insulin sensitivity.
2019, Pubmed
Ahlin,
Bile acid changes after metabolic surgery are linked to improvement in insulin sensitivity.
2019,
Pubmed
Artasensi,
Type 2 Diabetes Mellitus: A Review of Multi-Target Drugs.
2020,
Pubmed
Ballan,
Characteristics of the Gut Microbiota and Potential Effects of Probiotic Supplements in Individuals with Type 2 Diabetes mellitus.
2021,
Pubmed
Beysen,
Effect of bile acid sequestrants on glucose metabolism, hepatic de novo lipogenesis, and cholesterol and bile acid kinetics in type 2 diabetes: a randomised controlled study.
2012,
Pubmed
Claudel,
The Farnesoid X receptor: a molecular link between bile acid and lipid and glucose metabolism.
2005,
Pubmed
Dai,
Development and characterization of polymorphic microsatellite loci in the sea cucumber Holothuria leucospilota.
2015,
Pubmed
,
Echinobase
Delzenne,
Comparative hepatotoxicity of cholic acid, deoxycholic acid and lithocholic acid in the rat: in vivo and in vitro studies.
1992,
Pubmed
Dossa,
Bile acids regulate intestinal cell proliferation by modulating EGFR and FXR signaling.
2016,
Pubmed
Drzymała-Czyż,
Serum bile acids in cystic fibrosis patients - glycodeoxycholic acid as a potential marker of liver disease.
2022,
Pubmed
Fukuda,
Dietary fat, cholesterol, and cholic acid affect the histopathologic severity of nonalcoholic steatohepatitis in Sprague-Dawley rats.
2019,
Pubmed
Guariguata,
Global estimates of diabetes prevalence for 2013 and projections for 2035.
2014,
Pubmed
Honda,
Regulation of bile acid metabolism in mouse models with hydrophobic bile acid composition.
2020,
Pubmed
Hu,
Therapeutic medications against diabetes: What we have and what we expect.
2019,
Pubmed
Jiao,
Suppressed hepatic bile acid signalling despite elevated production of primary and secondary bile acids in NAFLD.
2018,
Pubmed
Lee,
The Relationship between the Gut Microbiome and Metformin as a Key for Treating Type 2 Diabetes Mellitus.
2021,
Pubmed
Li,
Chickpea Extract Ameliorates Metabolic Syndrome Symptoms via Restoring Intestinal Ecology and Metabolic Profile in Type 2 Diabetic Rats.
2021,
Pubmed
Nicholson,
'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data.
1999,
Pubmed
Ogurtsova,
IDF diabetes Atlas: Global estimates of undiagnosed diabetes in adults for 2021.
2022,
Pubmed
Prasad,
Autoimmune responses and inflammation in type 2 diabetes.
2020,
Pubmed
Wang,
Beneficial Effects of Holothuria leucospilota Polysaccharides on Fermentability In Vivo and In Vitro.
2021,
Pubmed
,
Echinobase
Wang,
Total flavonoids of Astragalus Ameliorated Bile Acid Metabolism Dysfunction in Diabetes Mellitus.
2021,
Pubmed
Xie,
Role of Bile Acids in the Regulation of Food Intake, and Their Dysregulation in Metabolic Disease.
2021,
Pubmed
Yuan,
Holothuria Leucospilota Polysaccharides Ameliorate Hyperlipidemia in High-Fat Diet-Induced Rats via Short-Chain Fatty Acids Production and Lipid Metabolism Regulation.
2019,
Pubmed
,
Echinobase
Yue,
Effects of theabrownin on serum metabolites and gut microbiome in rats with a high-sugar diet.
2019,
Pubmed
Zhang,
UPLC-Q-TOF/MS based fecal metabolomics reveals the potential anti-diabetic effect of Xiexin Decoction on T2DM rats.
2021,
Pubmed
Zhao,
A sea cucumber (Holothuria leucospilota) polysaccharide improves the gut microbiome to alleviate the symptoms of type 2 diabetes mellitus in Goto-Kakizaki rats.
2020,
Pubmed
,
Echinobase