Click
here to close Hello! We notice that
you are using Internet Explorer, which is not supported by Echinobase
and may cause the site to display incorrectly. We suggest using a
current version of Chrome,
FireFox,
or Safari.
Naunyn Schmiedebergs Arch Pharmacol
2024 Mar 01;3973:1803-1815. doi: 10.1007/s00210-023-02678-0.
Show Gene links
Show Anatomy links
Echinochrome exhibits anti-asthmatic activity through the suppression of airway inflammation, oxidative stress, and histopathological alterations in ovalbumin-induced asthma in BALB/c mice.
Abdelmawgood IA
,
Mahana NA
,
Badr AM
,
Mohamed AS
.
???displayArticle.abstract???
Asthma is a chronic pulmonary disease with marked infiltrating inflammatory cells and reduced respiratory performance. Echinochrome (Ech) is a dark-red pigment isolated from the sea urchin spines, shells, and ova. It has antioxidant, antimicrobial, and anti-inflammatory properties, but whether it can be used in asthma treatment has yet to be investigated. In this research, we aimed to study the inhibitory actions of Ech on allergic asthma symptoms in mice. Mice were divided into 4 groups (n = 8 for each): control, ovalbumin-challenged, and Ech-treated (0.1 and 1 mg/kg). At the end of the experiment, nasal scratching, lung oxidative stress, airway inflammation, and remodeling were assessed. In ovalbumin-challenged BALB/C mice, treatment with Ech significantly decreased nasal scratching, lung oxidative stress, inflammatory cell infiltration, mucus hyperproduction and hyperplasia of goblet cells, IgE levels, and inflammatory cytokines. It also inhibited NF-κB phosphorylation. This is the first study to investigate the immunomodulatory effect of Ech against allergic asthma in mice. According to our findings, we imply that Ech may be utilized as a treatment for allergic asthma.
Adam-Bonci,
Vitamin D Supplementation: Oxidative Stress Modulation in a Mouse Model of Ovalbumin-Induced Acute Asthmatic Airway Inflammation.
2021, Pubmed
Adam-Bonci,
Vitamin D Supplementation: Oxidative Stress Modulation in a Mouse Model of Ovalbumin-Induced Acute Asthmatic Airway Inflammation.
2021,
Pubmed
Antunes,
Airway inflammation induces anxiety-like behavior through neuroinflammatory, neurochemical, and neurometabolic changes in an allergic asthma model.
2022,
Pubmed
Aun,
Animal models of asthma: utility and limitations.
2017,
Pubmed
Bai,
Eupatilin Suppresses OVA-Induced Asthma by Inhibiting NF-κB and MAPK and Activating Nrf2 Signaling Pathways in Mice.
2022,
Pubmed
Barnes,
Cytokine-directed therapies for asthma.
2001,
Pubmed
Bureau,
Mechanisms of persistent NF-kappa B activity in the bronchi of an animal model of asthma.
2000,
Pubmed
Chung,
Role of inflammation in the hyperreactivity of the airways in asthma.
1986,
Pubmed
Dalouchi,
Human amniotic membrane mesenchymal stem cell-conditioned medium reduces inflammatory factors and fibrosis in ovalbumin-induced asthma in mice.
2021,
Pubmed
Dharmage,
Epidemiology of Asthma in Children and Adults.
2019,
Pubmed
Ducharme,
Inhaled corticosteroids versus leukotriene antagonists as first-line therapy for asthma: a systematic review of current evidence.
2004,
Pubmed
Dweik,
NO chemical events in the human airway during the immediate and late antigen-induced asthmatic response.
2001,
Pubmed
Economopoulos,
GSTM1, GSTT1, GSTP1, GSTA1 and colorectal cancer risk: a comprehensive meta-analysis.
2010,
Pubmed
Edwards,
Targeting the NF-kappaB pathway in asthma and chronic obstructive pulmonary disease.
2009,
Pubmed
Eftekhar,
Immunomodulatory and anti-inflammatory effects of hydro-ethanolic extract of Ocimum basilicum leaves and its effect on lung pathological changes in an ovalbumin-induced rat model of asthma.
2019,
Pubmed
Eger,
The emergence of new biologics for severe asthma.
2019,
Pubmed
Gillissen,
Inflammation and infections in asthma.
2015,
Pubmed
Huang,
Shikonin inhibits oxidized LDL-induced monocyte adhesion by suppressing NFκB activation via up-regulation of PI3K/Akt/Nrf2-dependent antioxidation in EA.hy926 endothelial cells.
2015,
Pubmed
Jassal,
Special considerations--asthma in children.
2015,
Pubmed
Jeong,
Echinochrome a increases mitochondrial mass and function by modulating mitochondrial biogenesis regulatory genes.
2014,
Pubmed
,
Echinobase
Jung,
Caffeic acid phenethyl ester attenuates allergic airway inflammation and hyperresponsiveness in murine model of ovalbumin-induced asthma.
2008,
Pubmed
Karthikeyan,
Promising bioactive compounds from the marine environment and their potential effects on various diseases.
2022,
Pubmed
Kim,
Comparison of asthma phenotypes in OVA-induced mice challenged via inhaled and intranasal routes.
2019,
Pubmed
Liu,
Protective effects on ovalbumin-induced mouse asthma models and qualitative and quantitative analysis of multiple compounds in Gerberae Piloselloidis Herba.
2022,
Pubmed
Mohamed,
Echinochrome Exhibits Antitumor Activity against Ehrlich Ascites Carcinoma in Swiss Albino Mice.
2021,
Pubmed
,
Echinobase
Nishida,
Change of Cu,Zn-superoxide dismutase activity of guinea pig lung in experimental asthma.
2002,
Pubmed
Oh,
Echinochrome A Reduces Colitis in Mice and Induces In Vitro Generation of Regulatory Immune Cells.
2019,
Pubmed
,
Echinobase
Ou,
The Protective Effects of Maresin 1 in the OVA-Induced Asthma Mouse Model.
2021,
Pubmed
Papon,
Marine drugs: Biology, pipelines, current and future prospects for production.
2022,
Pubmed
Park,
Echinochrome A Promotes Ex Vivo Expansion of Peripheral Blood-Derived CD34+ Cells, Potentially through Downregulation of ROS Production and Activation of the Src-Lyn-p110δ Pathway.
2019,
Pubmed
Park,
Echinochrome A Treatment Alleviates Fibrosis and Inflammation in Bleomycin-Induced Scleroderma.
2021,
Pubmed
,
Echinobase
Ray,
Th2 cells and GATA-3 in asthma: new insights into the regulation of airway inflammation.
1999,
Pubmed
Renz,
Inhibition of allergen-induced IgE and IgG1 production by soluble IL-4 receptor.
1995,
Pubmed
Rogers,
Oxidative Stress in the Lung - The Essential Paradox.
2018,
Pubmed
Sadeghi-Hashjin,
Peroxynitrite induces airway hyperresponsiveness in guinea pigs in vitro and in vivo.
1996,
Pubmed
Sadek,
Echinochrome pigment extracted from sea urchin suppress the bacterial activity, inflammation, nociception, and oxidative stress resulted in the inhibition of renal injury in septic rats.
2022,
Pubmed
,
Echinobase
Sahiner,
Oxidative stress in asthma: Part of the puzzle.
2018,
Pubmed
Scirica,
Predictors of cord blood IgE levels in children at risk for asthma and atopy.
2007,
Pubmed
Song,
IL-17-producing alveolar macrophages mediate allergic lung inflammation related to asthma.
2008,
Pubmed
Tanaka,
The effect of allergen-induced airway inflammation on airway remodeling in a murine model of allergic asthma.
2001,
Pubmed
Thakur,
An experimental model of asthma in rats using ovalbumin and lipopolysaccharide allergens.
2019,
Pubmed
Wang,
Aloperine suppresses allergic airway inflammation through NF-κB, MAPK, and Nrf2/HO-1 signaling pathways in mice.
2018,
Pubmed
Wang,
Effect of Tiotropium Bromide on Airway Inflammation and Programmed Cell Death 5 in a Mouse Model of Ovalbumin-Induced Allergic Asthma.
2019,
Pubmed
Wang,
Pharmacological Mechanisms Underlying the Anti-asthmatic Effects of Modified Guomin Decoction Determined by Network Pharmacology and Molecular Docking.
2021,
Pubmed
Wang,
Ligustrazine Inhibits Lung Phosphodiesterase Activity in a Rat Model of Allergic Asthma.
2022,
Pubmed
Woolcock,
Steroid resistant asthma: what is the clinical definition?
1993,
Pubmed
Xiao,
Dexmedetomidine attenuates airway inflammation and oxidative stress in asthma via the Nrf2 signaling pathway.
2023,
Pubmed
Zhang,
Propofol inhibits NF-κB activation to ameliorate airway inflammation in ovalbumin (OVA)-induced allergic asthma mice.
2017,
Pubmed
Zheng,
Hydroxysafflor Yellow A Alleviates Ovalbumin-Induced Asthma in a Guinea Pig Model by Attenuateing the Expression of Inflammatory Cytokines and Signal Transduction.
2019,
Pubmed
Zhou,
Inhibition of allergic airway inflammation through the blockage of NF-κB activation by ellagic acid in an ovalbumin-induced mouse asthma model.
2014,
Pubmed
Zhu,
The Role of T Cells and Macrophages in Asthma Pathogenesis: A New Perspective on Mutual Crosstalk.
2020,
Pubmed
Zhu,
The protective role of Zingerone in a murine asthma model via activation of the AMPK/Nrf2/HO-1 pathway.
2021,
Pubmed
