Click
here to close Hello! We notice that
you are using Internet Explorer, which is not supported by Echinobase
and may cause the site to display incorrectly. We suggest using a
current version of Chrome,
FireFox,
or Safari.
Matern Child Health J
2023 Apr 01;274:737-746. doi: 10.1007/s10995-022-03553-9.
Show Gene links
Show Anatomy links
Impact of the Presence Anti-SARS-CoV-2 IgA in the Colostrum of Women Infected by COVID-19 During the Pregnancy in Neonatal Clinical Outcomes: A Cross-Sectional Study.
???displayArticle.abstract???
OBJECTIVES: To describe the presence of anti-SARS-CoV-2 IgA and IgG in the blood and colostrum of women with COVID-19 infection during pregnancy and associate the presence of anti-SARS-CoV-2 IgA in colostrum with clinical symptoms of their newborns.
METHODS: A cross-sectional study was developed with 165 participants with COVID-19 infection during pregnancy and their newborns.
DATA COLLECTED: characteristics COVID-19 infection in pregnant women, gestational age, and clinical symptoms in their newborns (fever, hypothermia, respiratory distress, hypotonia, hypoactivity, hypoglycemia, cyanosis, vomiting/regurgitation, abdominal distention, and jaundice). Maternal blood and colostrum samples were collected postpartum to to detect the presence of IgA and IgG anti-SARS-CoV-2.
RESULTS: The median interval between COVID-19 diagnosis and delivery was 37.5 days (IQ = 12.0, 73.0 days). Clinical symptoms during hospitalization were observed in 55 newborns (33.3%), and two (1.6%) tested RT-PCR positive for COVID-19. Positive colostrum for anti-SARS-CoV-2 IgA was found in 117 (70.9%) women. The presence of anti-SARS-CoV-2 IgA in colostrum was associated independently with lower clinical symptoms in their newborns (OR = 0.42; 95% CI 0.202 to 0.84; p = 0.015).
CONCLUSIONS FOR PRACTICE: The presence of anti-SARS-CoV-2 IgA in colostrum was detected in more than two-thirds of the women evaluated and was associated with a lower frequency of clinical symptoms in their newborns.
Bahadur,
Retrospective observational RT-PCR analyses on 688 babies born to 843 SARS-CoV-2 positive mothers, placental analyses and diagnostic analyses limitations suggest vertical transmission is possible.
2021, Pubmed
Bahadur,
Retrospective observational RT-PCR analyses on 688 babies born to 843 SARS-CoV-2 positive mothers, placental analyses and diagnostic analyses limitations suggest vertical transmission is possible.
2021,
Pubmed
Ballard,
New Ballard Score, expanded to include extremely premature infants.
1991,
Pubmed
Benoit,
False negative RT-PCR or false positive serological testing in SARS-CoV-2 diagnostics? Navigating between Scylla and Charybdis to prevent misclassification bias in COVID-19 clinical investigations.
2020,
Pubmed
Civra,
Human Colostrum and Derived Extracellular Vesicles Prevent Infection by Human Rotavirus and Respiratory Syncytial Virus in Vitro.
2021,
Pubmed
Demers-Mathieu,
Human Milk Antibodies Against S1 and S2 Subunits from SARS-CoV-2, HCoV-OC43, and HCoV-229E in Mothers with A Confirmed COVID-19 PCR, Viral SYMPTOMS, and Unexposed Mothers.
2021,
Pubmed
Demers-Mathieu,
Previous viral symptoms and individual mothers influenced the leveled duration of human milk antibodies cross-reactive to S1 and S2 subunits from SARS-CoV-2, HCoV-229E, and HCoV-OC43.
2021,
Pubmed
Duncombe,
Dynamics of breast milk antibody titer in the six months following SARS-CoV-2 infection.
2021,
Pubmed
Díaz-Corvillón,
Routine screening for SARS CoV-2 in unselected pregnant women at delivery.
2020,
Pubmed
Elshafeey,
A systematic scoping review of COVID-19 during pregnancy and childbirth.
2020,
Pubmed
Galipeau,
Humoral Responses and Serological Assays in SARS-CoV-2 Infections.
2020,
Pubmed
Giuliani,
Effects of prenatal exposure to maternal COVID-19 and perinatal care on neonatal outcome: results from the INTERCOVID Multinational Cohort Study.
2022,
Pubmed
Gonçalves-Ferri,
The impact of coronavirus outbreak on breastfeeding guidelines among Brazilian hospitals and maternity services: a cross-sectional study.
2021,
Pubmed
Grant,
Reply: "Vitamin D Supplementation in Influenza and COVID-19 Infections. Comment on: Evidence That Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths Nutrients 2020, 12(4), 988".
2020,
Pubmed
Jamieson,
An update on COVID-19 and pregnancy.
2022,
Pubmed
Juncker,
Antibodies Against SARS-CoV-2 in Human Milk: Milk Conversion Rates in the Netherlands.
2021,
Pubmed
Lebrão,
Early Identification of IgA Anti-SARSCoV-2 in Milk of Mother With COVID-19 Infection.
2020,
Pubmed
Low,
Titres and neutralising capacity of SARS-CoV-2-specific antibodies in human milk: a systematic review.
2022,
Pubmed
Moraes-Pinto,
Immune system: development and acquisition of immunological competence.
2021,
Pubmed
Narayanaswamy,
Humoral and Cell-Mediated Immune Response in Colostrum from Women Diagnosed Positive for SARS-CoV-2.
2021,
Pubmed
Nayak,
Neonatal outcomes of pregnant women with COVID-19 in a developing country setup.
2021,
Pubmed
Pace,
Milk From Women Diagnosed With COVID-19 Does Not Contain SARS-CoV-2 RNA but Has Persistent Levels of SARS-CoV-2-Specific IgA Antibodies.
2021,
Pubmed
Pietrasanta,
Humoral response to anti-SARS-CoV-2 vaccine in breastfeeding mothers and mother-to-infant antibody transfer through breast milk.
2022,
Pubmed
Sevilla-Montoya,
Evidence of possible SARS-CoV-2 vertical transmission according to World Health Organization criteria in asymptomatic pregnant women.
2021,
Pubmed
Thompson,
COVID-19-related disease severity in pregnancy.
2020,
Pubmed
Victora,
Breastfeeding in the 21st century: epidemiology, mechanisms, and lifelong effect.
2016,
Pubmed
Villar,
Maternal and Neonatal Morbidity and Mortality Among Pregnant Women With and Without COVID-19 Infection: The INTERCOVID Multinational Cohort Study.
2021,
Pubmed
Wang,
Enhanced SARS-CoV-2 neutralization by dimeric IgA.
2021,
Pubmed
Zhu,
SARS-CoV-2 genome and antibodies in breastmilk: a systematic review and meta-analysis.
2021,
Pubmed