Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Echinobase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
Echinobase
ECB-ART-52280
Pharmaceuticals (Basel) 2022 Oct 20;1510:. doi: 10.3390/ph15101294.
Show Gene links Show Anatomy links

Ginkgo biloba Extract Stimulates Adipogenesis in 3T3-L1 Preadipocytes.

Thomaz FM , de Jesus Simão J , da Silva VS , Machado MMF , Oyama LM , Ribeiro EB , Alonso Vale MIC , Telles MM .


???displayArticle.abstract???
Smaller adipocytes are related to the reversal of metabolic disorders, suggesting that molecules that can act in the adipogenesis pathway are of great interest. The objective of this study was to investigate the effect of Ginkgo biloba extract (GbE) in modulating the differentiation in preadipocytes. 3T3-L1 preadipocytes were differentiated for 7 days into adipocytes without (control group) and with GbE at 1.0 mg/mL. Lipid content and gene expression were analyzed on day 7 (D7) by Oil Red O staining and PCR Array Gene Expression. Western blotting analysis of the key adipogenesis markers was evaluated during the differentiation process at days 3 (D3), 5 (D5), and 7 (D7). GbE increased lipid content and raised the gene expression of the main adipogenesis markers. Key proteins of the differentiation process were modulated by GbE, since C/EBPβ levels were decreased, while C/EBPα levels were increased at D7. Regarding the mature adipocytes' markers, GbE enhanced the levels of both FABP4 at D5, and perilipin at D3 and D5. In summary, the present findings showed that GbE modulated the adipogenesis pathway suggesting that the treatment could accelerate the preadipocyte maturation, stimulating the expression of mature adipocyte proteins earlier than expected.

???displayArticle.pubmedLink??? 36297406
???displayArticle.link??? Pharmaceuticals (Basel)
???displayArticle.grants??? [+]


References [+] :
Ahn, The anti-obesity effect of quercetin is mediated by the AMPK and MAPK signaling pathways. 2008, Pubmed