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Int J Gen Med
2023 Jan 01;16:1747-1755. doi: 10.2147/IJGM.S399806.
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Ophthalmic Manifestations Among Patients Surviving COVID-19.
Loduca Lima V
,
Soares LCM
,
Pereira LA
,
Nascimento PA
,
Cirillo LRN
,
Sakuma HT
,
da Veiga GL
,
Abucham-Neto JZ
,
Fonseca FLA
.
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BACKGROUND AND AIM: To identify ocular findings related to SARS-CoV-2 infection in patients after the resolution of COVID-19 using complete ocular examinations and optical coherence tomography (OCT).
METHODS: In this cross-sectional study, conducted from May 30 to October 30, 2020, patients who recovered from various stages COVID-19 underwent eye examination and multimodal retinal imaging (Retinographies and Spectral-OCT).
RESULTS: We included 50 patients, 29 (58%) males, median age of 46.5 [standard deviation 15.8]. Of these, 42% (21) had mild, 18% (9) had severe and 40% (20) had critical disease. The median time interquartile range (IQR) between symptom onset and ocular examination was 55 days [IQR 39-71]. Seven patients (14%) reported ophthalmic symptoms, transitory low visual acuity (6%) and retroocular pain (8%). On OCT, one patient without comorbidities had sectoral retinal pallor suggestive of acute retinal ischaemia and oedema of the retina's inner layers and atrophy. All findings progressively and spontaneously improved months after resolution of COVID-19.
CONCLUSION: Patients with COVID-19 present findings compatible with the general population depending on age and comorbidities; nevertheless, acute retinal findings associated with the disease may be present, such as caused either by the direct effects of retinal SARS-CoV-2 infection, by indirect effects of the cytokine storm or by the pro-thrombotic state associated with COVID-19. Therefore, retinal involvement in patients with COVID-19 remains subject to considerable discussion and study.
Casagrande,
Detection of SARS-CoV-2 in Human Retinal Biopsies of Deceased COVID-19 Patients.
2020, Pubmed
Casagrande,
Detection of SARS-CoV-2 in Human Retinal Biopsies of Deceased COVID-19 Patients.
2020,
Pubmed
Guan,
Clinical Characteristics of Coronavirus Disease 2019 in China.
2020,
Pubmed
Guzzi,
Master Regulator Analysis of the SARS-CoV-2/Human Interactome.
2020,
Pubmed
Huang,
Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China.
2020,
Pubmed
Iba,
Coagulopathy of Coronavirus Disease 2019.
2020,
Pubmed
Invernizzi,
Retinal findings in patients with COVID-19: Results from the SERPICO-19 study.
2020,
Pubmed
Jaworski,
Morphology of the HIV versus the diabetic cotton wool spot.
2000,
Pubmed
Kochi,
Cardiac and arrhythmic complications in patients with COVID-19.
2020,
Pubmed
Lai,
Extra-respiratory manifestations of COVID-19.
2020,
Pubmed
Landecho,
COVID-19 retinal microangiopathy as an in vivo biomarker of systemic vascular disease?
2021,
Pubmed
Lu,
Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding.
2020,
Pubmed
Marinho,
Retinal findings in patients with COVID-19.
2020,
Pubmed
Mehta,
COVID-19: consider cytokine storm syndromes and immunosuppression.
2020,
Pubmed
Pereira,
Retinal findings in hospitalised patients with severe COVID-19.
2022,
Pubmed
Pirraglia,
Retinal involvement and ocular findings in COVID-19 pneumonia patients.
2020,
Pubmed
Raony,
Retinal outcomes of COVID-19: Possible role of CD147 and cytokine storm in infected patients with diabetes mellitus.
2020,
Pubmed
Romero-Castro,
POSTERIOR SEGMENT OCULAR FINDINGS IN CRITICALLY ILL PATIENTS WITH COVID-19.
2022,
Pubmed
Sgorlon,
Clinical and epidemiological aspects of Delta and Gamma SARS-CoV-2 variant of concern from the western Brazilian Amazon.
2023,
Pubmed
Varga,
Endothelial cell infection and endotheliitis in COVID-19.
2020,
Pubmed
Wong,
The prevalence and risk factors of retinal microvascular abnormalities in older persons: The Cardiovascular Health Study.
2003,
Pubmed
Wu,
Characteristics of Ocular Findings of Patients With Coronavirus Disease 2019 (COVID-19) in Hubei Province, China.
2020,
Pubmed
Xia,
Evaluation of coronavirus in tears and conjunctival secretions of patients with SARS-CoV-2 infection.
2020,
Pubmed
Zhang,
Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target.
2020,
Pubmed
