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Nat Commun
2021 Nov 18;121:6688. doi: 10.1038/s41467-021-27005-0.
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Diversity, multifaceted evolution, and facultative saprotrophism in the European Batrachochytrium salamandrivorans epidemic.
Kelly M
,
Pasmans F
,
Muñoz JF
,
Shea TP
,
Carranza S
,
Cuomo CA
,
Martel A
.
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While emerging fungi threaten global biodiversity, the paucity of fungal genome assemblies impedes thoroughly characterizing epidemics and developing effective mitigation strategies. Here, we generate de novo genomic assemblies for six outbreaks of the emerging pathogen Batrachochytrium salamandrivorans (Bsal). We reveal the European epidemic currently damaging amphibian populations to comprise multiple, highly divergent lineages demonstrating isolate-specific adaptations and metabolic capacities. In particular, we show extensive gene family expansions and acquisitions, through a variety of evolutionary mechanisms, and an isolate-specific saprotrophic lifecycle. This finding both explains the chytrid's ability to divorce transmission from host density, producing Bsal's enigmatic host population declines, and is a key consideration in developing successful mitigation measures.
Abyzov,
CNVnator: an approach to discover, genotype, and characterize typical and atypical CNVs from family and population genome sequencing.
2011, Pubmed
Abyzov,
CNVnator: an approach to discover, genotype, and characterize typical and atypical CNVs from family and population genome sequencing.
2011,
Pubmed
Altschul,
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs.
1997,
Pubmed
Besemer,
GeneMark: web software for gene finding in prokaryotes, eukaryotes and viruses.
2005,
Pubmed
Bongomin,
Global and Multi-National Prevalence of Fungal Diseases-Estimate Precision.
2017,
Pubmed
Chin,
Phased diploid genome assembly with single-molecule real-time sequencing.
2016,
Pubmed
Cingolani,
A program for annotating and predicting the effects of single nucleotide polymorphisms, SnpEff: SNPs in the genome of Drosophila melanogaster strain w1118; iso-2; iso-3.
2012,
Pubmed
Conesa,
Blast2GO: a universal tool for annotation, visualization and analysis in functional genomics research.
2005,
Pubmed
Cunningham,
Emerging disease in UK amphibians.
2015,
Pubmed
Danecek,
The variant call format and VCFtools.
2011,
Pubmed
Dunham,
Characteristic genome rearrangements in experimental evolution of Saccharomyces cerevisiae.
2002,
Pubmed
Eddy,
Accelerated Profile HMM Searches.
2011,
Pubmed
Emms,
OrthoFinder: solving fundamental biases in whole genome comparisons dramatically improves orthogroup inference accuracy.
2015,
Pubmed
Farrer,
Genomic innovations linked to infection strategies across emerging pathogenic chytrid fungi.
2017,
Pubmed
Finn,
Pfam: the protein families database.
2014,
Pubmed
Fisher,
Emerging fungal threats to animal, plant and ecosystem health.
2012,
Pubmed
Fisher,
Chytrid fungi and global amphibian declines.
2020,
Pubmed
Fitzpatrick,
Epidemiological tracing of Batrachochytrium salamandrivorans identifies widespread infection and associated mortalities in private amphibian collections.
2018,
Pubmed
Fogel,
Gene amplification in yeast: CUP1 copy number regulates copper resistance.
1983,
Pubmed
Greener,
Presence of low virulence chytrid fungi could protect European amphibians from more deadly strains.
2020,
Pubmed
Henriksson,
A critical review of cellobiose dehydrogenases.
2000,
Pubmed
Ho,
Time-dependent rates of molecular evolution.
2011,
Pubmed
Kasuga,
Estimation of nucleotide substitution rates in Eurotiomycete fungi.
2002,
Pubmed
Koren,
Canu: scalable and accurate long-read assembly via adaptive k-mer weighting and repeat separation.
2017,
Pubmed
Krogh,
Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.
2001,
Pubmed
Kubicek,
Plant cell wall-degrading enzymes and their secretion in plant-pathogenic fungi.
2014,
Pubmed
Laking,
Batrachochytrium salamandrivorans is the predominant chytrid fungus in Vietnamese salamanders.
2017,
Pubmed
Lange,
Enzymes of early-diverging, zoosporic fungi.
2019,
Pubmed
Li,
The Sequence Alignment/Map format and SAMtools.
2009,
Pubmed
Lin,
Assembly of long error-prone reads using de Bruijn graphs.
2016,
Pubmed
Lockhart,
Simultaneous Emergence of Multidrug-Resistant Candida auris on 3 Continents Confirmed by Whole-Genome Sequencing and Epidemiological Analyses.
2017,
Pubmed
Martel,
Wildlife disease. Recent introduction of a chytrid fungus endangers Western Palearctic salamanders.
2014,
Pubmed
Martel,
Batrachochytrium salamandrivorans sp. nov. causes lethal chytridiomycosis in amphibians.
2013,
Pubmed
Mitchell,
Persistence of the emerging pathogen Batrachochytrium dendrobatidis outside the amphibian host greatly increases the probability of host extinction.
2008,
Pubmed
Na Pombejra,
The structure-function analysis of the Mpr1 metalloprotease determinants of activity during migration of fungal cells across the blood-brain barrier.
2018,
Pubmed
O'Hanlon,
Recent Asian origin of chytrid fungi causing global amphibian declines.
2018,
Pubmed
Petersen,
SignalP 4.0: discriminating signal peptides from transmembrane regions.
2011,
Pubmed
Podell,
DarkHorse: a method for genome-wide prediction of horizontal gene transfer.
2007,
Pubmed
Quinlan,
BEDTools: a flexible suite of utilities for comparing genomic features.
2010,
Pubmed
Rancurel,
Alienness: Rapid Detection of Candidate Horizontal Gene Transfers across the Tree of Life.
2017,
Pubmed
Rawlings,
MEROPS: the database of proteolytic enzymes, their substrates and inhibitors.
2014,
Pubmed
Refsnider,
Genomic Correlates of Virulence Attenuation in the Deadly Amphibian Chytrid Fungus, Batrachochytrium dendrobatidis.
2015,
Pubmed
Richgels,
Spatial variation in risk and consequence of Batrachochytrium salamandrivorans introduction in the USA.
2016,
Pubmed
Rytioja,
Plant-polysaccharide-degrading enzymes from Basidiomycetes.
2014,
Pubmed
Scheele,
Amphibian fungal panzootic causes catastrophic and ongoing loss of biodiversity.
2019,
Pubmed
Selin,
Elucidating the Role of Effectors in Plant-Fungal Interactions: Progress and Challenges.
2016,
Pubmed
Spitzen-van der Sluijs,
Expanding Distribution of Lethal Amphibian Fungus Batrachochytrium salamandrivorans in Europe.
2016,
Pubmed
Spitzen-van der Sluijs,
Post-epizootic salamander persistence in a disease-free refugium suggests poor dispersal ability of Batrachochytrium salamandrivorans.
2018,
Pubmed
Stanke,
AUGUSTUS: ab initio prediction of alternative transcripts.
2006,
Pubmed
Stegen,
Drivers of salamander extirpation mediated by Batrachochytrium salamandrivorans.
2017,
Pubmed
Stukenbrock,
Origin and domestication of the fungal wheat pathogen Mycosphaerella graminicola via sympatric speciation.
2007,
Pubmed
Sun,
Contribution of Multiple Inter-Kingdom Horizontal Gene Transfers to Evolution and Adaptation of Amphibian-Killing Chytrid, Batrachochytrium dendrobatidis.
2016,
Pubmed
Upadhya,
Cryptococcus neoformans Cda1 and Its Chitin Deacetylase Activity Are Required for Fungal Pathogenesis.
2018,
Pubmed
Vu,
Invasion of the central nervous system by Cryptococcus neoformans requires a secreted fungal metalloprotease.
2014,
Pubmed
Woo,
The mitochondrial genome of the thermal dimorphic fungus Penicillium marneffei is more closely related to those of molds than yeasts.
2003,
Pubmed
Zhan,
The interaction among evolutionary forces in the pathogenic fungus Mycosphaerella graminicola.
2004,
Pubmed
Zheng,
A high-performance computing toolset for relatedness and principal component analysis of SNP data.
2012,
Pubmed
