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Heliyon
2023 Jan 01;91:e12707. doi: 10.1016/j.heliyon.2022.e12707.
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Effects of kefir fermented milk beverage on sodium dextran sulfate (DSS)-induced colitis in rats.
Nascimento da Silva K
,
Fávero AG
,
Ribeiro W
,
Ferreira CM
,
Sartorelli P
,
Cardili L
,
Bogsan CS
,
Bertaglia Pereira JN
,
de Cássia Sinigaglia R
,
Cristina de Moraes Malinverni A
,
Ribeiro Paiotti AP
,
Miszputen SJ
,
Ambrogini-Júnior O
.
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BACKGROUND AND AIM: The etiopathogenesis of inflammatory bowel disease (IBD) is associated with different factors such as genetic, infectious, immunological, and environmental, including modification of the gut microbiota. IBD's conventional pharmacological therapeutic approaches have become a challenge due to side effects, complications from prolonged use, and higher costs. Kefir fermented milk beverage is a functional food that has demonstrated multiple beneficial effects including anti-inflammatory and antioxidant activity. Alternative therapeutic strategies have been used for IBD as more natural products with low-cost and easy acquisition. The aim of this study is to evaluate the anti-inflammatory effects of kefir fermented milk beverage on sodium dextran sulfate (DSS)-induced colitis in rats.
METHODS: We used 4 groups to perform this study: baseline control (BC), kefir control (KC), 5% untreated DSS-induced colitis (DSS), and 5% DSS-induced colitis treated with kefir (DSSK). The animals received fermented kefir milk beverage ad libitum for six days and the disease activity index was recorded daily. Colon samples were processed for Transmission Electron Microscopy and histopathological evaluation. We analyzed short fatty chain acids through the fecal sample using gas chromatography.
RESULTS: Kefir supplementation was able to reduce the clinical activity index and inflammatory process evidenced by decreased neutrophil accumulation, decreased reticulum edema, and increased autophagosomes. Also, showed a trend to increase the levels of acetate and propionate.
CONCLUSIONS: Our results suggest that kefir fermented milk beverage may have an anti-inflammatory effect minimizing the intestinal damage of DSS-induced colitis.
Bell,
One Health, Fermented Foods, and Gut Microbiota.
2018, Pubmed
Bell,
One Health, Fermented Foods, and Gut Microbiota.
2018,
Pubmed
Cai,
Treatment of Inflammatory Bowel Disease: A Comprehensive Review.
2021,
Pubmed
Cavaglieri,
Differential effects of short-chain fatty acids on proliferation and production of pro- and anti-inflammatory cytokines by cultured lymphocytes.
2003,
Pubmed
Celiberto,
Inflammatory bowel disease and immunonutrition: novel therapeutic approaches through modulation of diet and the gut microbiome.
2018,
Pubmed
Chen,
Lactobacillus kefiranofaciens M1 isolated from milk kefir grains ameliorates experimental colitis in vitro and in vivo.
2012,
Pubmed
Collado,
Potential probiotic characteristics of Lactobacillus and Enterococcus strains isolated from traditional dadih fermented milk against pathogen intestinal colonization.
2007,
Pubmed
Constante,
Iron Supplements Modulate Colon Microbiota Composition and Potentiate the Protective Effects of Probiotics in Dextran Sodium Sulfate-induced Colitis.
2017,
Pubmed
Curciarello,
Probiotic Lactobacilli Isolated from Kefir Promote Down-Regulation of Inflammatory Lamina Propria T Cells from Patients with Active IBD.
2021,
Pubmed
Currò,
Probiotics, fibre and herbal medicinal products for functional and inflammatory bowel disorders.
2017,
Pubmed
Daly,
The importance of colonic butyrate transport to the regulation of genes associated with colonic tissue homoeostasis.
2005,
Pubmed
Di Sabatino,
Oral butyrate for mildly to moderately active Crohn's disease.
2005,
Pubmed
Dieleman,
Chronic experimental colitis induced by dextran sulphate sodium (DSS) is characterized by Th1 and Th2 cytokines.
1998,
Pubmed
Ewaschuk,
Bioproduction of conjugated linoleic acid by probiotic bacteria occurs in vitro and in vivo in mice.
2006,
Pubmed
Furuno,
Kefiran suppresses antigen-induced mast cell activation.
2012,
Pubmed
Furusawa,
Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells.
2013,
Pubmed
Gasaly,
Butyrate and the Fine-Tuning of Colonic Homeostasis: Implication for Inflammatory Bowel Diseases.
2021,
Pubmed
Ghoneum,
Apoptotic effect of a novel kefir product, PFT, on multidrug-resistant myeloid leukemia cells via a hole-piercing mechanism.
2014,
Pubmed
Groulx,
Autophagy is active in normal colon mucosa.
2012,
Pubmed
Hamet,
Oral administration of kefiran exerts a bifidogenic effect on BALB/c mice intestinal microbiota.
2016,
Pubmed
Huseini,
Evaluation of wound healing activities of kefir products.
2012,
Pubmed
Kabak,
An introduction to the traditional fermented foods and beverages of Turkey.
2011,
Pubmed
Kaiko,
The Colonic Crypt Protects Stem Cells from Microbiota-Derived Metabolites.
2016,
Pubmed
Kaisar,
Butyrate Conditions Human Dendritic Cells to Prime Type 1 Regulatory T Cells via both Histone Deacetylase Inhibition and G Protein-Coupled Receptor 109A Signaling.
2017,
Pubmed
Kang,
Extracellular Vesicles Derived from Kefir Grain Lactobacillus Ameliorate Intestinal Inflammation via Regulation of Proinflammatory Pathway and Tight Junction Integrity.
2020,
Pubmed
Kaplan,
The global burden of IBD: from 2015 to 2025.
2015,
Pubmed
Khan,
Alteration of Gut Microbiota in Inflammatory Bowel Disease (IBD): Cause or Consequence? IBD Treatment Targeting the Gut Microbiome.
2019,
Pubmed
Kok,
Yogurt and other fermented foods as sources of health-promoting bacteria.
2018,
Pubmed
Kühbacher,
Bacterial and fungal microbiota in relation to probiotic therapy (VSL#3) in pouchitis.
2006,
Pubmed
Levine,
Autophagy in the pathogenesis of disease.
2008,
Pubmed
Lührs,
Butyrate-enhanced TNFalpha-induced apoptosis is associated with inhibition of NF-kappaB.
2002,
Pubmed
Maciel,
Immunomodulation and nitric oxide restoration by a probiotic and its activity in gut and peritoneal macrophages in diabetic rats.
2016,
Pubmed
Martini,
Mend Your Fences: The Epithelial Barrier and its Relationship With Mucosal Immunity in Inflammatory Bowel Disease.
2017,
Pubmed
Medrano,
Oral administration of kefiran induces changes in the balance of immune cells in a murine model.
2011,
Pubmed
Mendes,
Preventive oral kefir supplementation protects mice from ovariectomy-induced exacerbated allergic airway inflammation.
2021,
Pubmed
Merga,
Mucosal barrier, bacteria and inflammatory bowel disease: possibilities for therapy.
2014,
Pubmed
Mijan,
Diets, functional foods, and nutraceuticals as alternative therapies for inflammatory bowel disease: Present status and future trends.
2018,
Pubmed
Nighot,
Autophagy enhances intestinal epithelial tight junction barrier function by targeting claudin-2 protein degradation.
2015,
Pubmed
Ocansey,
Exosome-mediated effects and applications in inflammatory bowel disease.
2020,
Pubmed
Ocansey,
Mesenchymal stem cell-gut microbiota interaction in the repair of inflammatory bowel disease: an enhanced therapeutic effect.
2019,
Pubmed
Parra,
Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil.
2019,
Pubmed
Peluzio,
Kefir and Intestinal Microbiota Modulation: Implications in Human Health.
2021,
Pubmed
Punaro,
Kefir administration reduced progression of renal injury in STZ-diabetic rats by lowering oxidative stress.
2014,
Pubmed
Purchiaroni,
The role of intestinal microbiota and the immune system.
2013,
Pubmed
Ribeiro,
Use of Gas Chromatography to Quantify Short Chain Fatty Acids in the Serum, Colonic Luminal Content and Feces of mice.
2018,
Pubmed
Rosa,
Milk kefir: nutritional, microbiological and health benefits.
2017,
Pubmed
Saez-Lara,
The role of probiotic lactic acid bacteria and bifidobacteria in the prevention and treatment of inflammatory bowel disease and other related diseases: a systematic review of randomized human clinical trials.
2015,
Pubmed
Sakiyama,
Glutamine increases autophagy under Basal and stressed conditions in intestinal epithelial cells.
2009,
Pubmed
Segain,
Butyrate inhibits inflammatory responses through NFkappaB inhibition: implications for Crohn's disease.
2000,
Pubmed
Senol,
Kefir treatment ameliorates dextran sulfate sodium-induced colitis in rats.
2015,
Pubmed
Seo,
Therapeutic effects of kefir grain Lactobacillus-derived extracellular vesicles in mice with 2,4,6-trinitrobenzene sulfonic acid-induced inflammatory bowel disease.
2018,
Pubmed
Sevencan,
Dose-dependent effects of kefir on colitis induced by trinitrobenzene sulfonic acid in rats.
2019,
Pubmed
Shin,
Regulatory Effect of Lactobacillus brevis Bmb6 on Gut Barrier Functions in Experimental Colitis.
2020,
Pubmed
Simčič,
Engineered and wild-type L. lactis promote anti-inflammatory cytokine signalling in inflammatory bowel disease patient's mucosa.
2019,
Pubmed
Singh,
Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis.
2014,
Pubmed
Sivaprakasam,
Benefits of short-chain fatty acids and their receptors in inflammation and carcinogenesis.
2016,
Pubmed
Sjögren,
Altered early infant gut microbiota in children developing allergy up to 5 years of age.
2009,
Pubmed
Sánchez-Fidalgo,
Dietary extra virgin olive oil polyphenols supplementation modulates DSS-induced chronic colitis in mice.
2013,
Pubmed
Tedelind,
Anti-inflammatory properties of the short-chain fatty acids acetate and propionate: a study with relevance to inflammatory bowel disease.
2007,
Pubmed
Tong,
Propionate Ameliorates Dextran Sodium Sulfate-Induced Colitis by Improving Intestinal Barrier Function and Reducing Inflammation and Oxidative Stress.
2016,
Pubmed
Ungaro,
Ulcerative colitis.
2017,
Pubmed
Yılmaz,
Effect of administering kefir on the changes in fecal microbiota and symptoms of inflammatory bowel disease: A randomized controlled trial.
2019,
Pubmed
Zhou,
Analysis of the microflora in Tibetan kefir grains using denaturing gradient gel electrophoresis.
2009,
Pubmed
de Alencar Junior,
The relationship between the commensal microbiota levels and Crohn's disease activity.
2020,
Pubmed
Şanlier,
Health benefits of fermented foods.
2019,
Pubmed
