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Front Pharmacol
2022 Jan 01;13:1013703. doi: 10.3389/fphar.2022.1013703.
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Propolis induces cardiac metabolism changes in 6-hydroxydopamine animal model: A dietary intervention as a potential cardioprotective approach in Parkinson's disease.
Goncalves VC
,
Silva da Fonsêca V
,
de Paula Faria D
,
Izidoro MA
,
Berretta AA
,
de Almeida AG
,
Affonso Fonseca FL
,
Scorza FA
,
Scorza CA
.
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While there is sustained growth of the older population worldwide, ageing is a consistent risk factor for neurodegenerative diseases, such as Parkinson's-disease (PD). Considered an emblematic movement disorder, PD comprises a miscellany of non-motor symptoms, for which effective management remains an unfulfilled need in clinical practice. Highlighted are the cardiovascular abnormalities, that cause significant burden in PD patients. Evidence suggests that key biological processes underlying PD pathophysiology can be modulated by diet-derived bioactive compounds, such as green propolis, a natural functional food with biological and pharmacological properties. The effects of propolis on cardiac affection associated to PD have received little coverage. In this study, a metabolomics approach and Positron Emission Tomography (PET) imaging were used to assess the metabolic response to diet supplementation with green propolis on heart outcomes of rats with Parkinsonism induced by 6-hydroxydopamine (6-OHDA rats). Untargeted metabolomics approach revealed four cardiac metabolites (2-hydroxybutyric acid, 3-hydroxybutyric acid, monoacylglycerol and alanine) that were significantly modified between animal groups (6-OHDA, 6-OHDA + Propolis and sham). Propolis-induced changes in the level of these cardiac metabolites suggest beneficial effects of diet intervention. From the metabolites affected, functional analysis identified changes in propanoate metabolism (a key carbohydrate metabolism related metabolic pathway), glucose-alanine cycle, protein and fatty acid biosynthesis, energy metabolism, glutathione metabolism and urea cycle. PET imaging detected higher glucose metabolism in the 17 areas of the left ventricle of all rats treated with propolis, substantially contrasting from those rats that did not consume propolis. Our results bring new insights into cardiac metabolic substrates and pathways involved in the mechanisms of the effects of propolis in experimental PD and provide potential novel targets for research in the quest for future therapeutic strategies.
Ahlin,
Metabolite Changes After Metabolic Surgery - Associations to Parameters Reflecting Glucose Homeostasis and Lipid Levels.
2021, Pubmed
Ahlin,
Metabolite Changes After Metabolic Surgery - Associations to Parameters Reflecting Glucose Homeostasis and Lipid Levels.
2021,
Pubmed
Ali,
Apitherapy for Parkinson's Disease: A Focus on the Effects of Propolis and Royal Jelly.
2020,
Pubmed
Aoyama,
Glutathione in the Brain.
2021,
Pubmed
Aoyama,
Inhibition of GTRAP3-18 may increase neuroprotective glutathione (GSH) synthesis.
2012,
Pubmed
Arabameri,
The effects of propolis extract on ovarian tissue and oxidative stress in rats with maternal separation stress.
2017,
Pubmed
Ariza,
Chemoreflex and baroreflex alterations in Parkinsonism induced by 6-OHDA in unanesthetized rats.
2015,
Pubmed
Bazmandegan,
Brown propolis attenuates cerebral ischemia-induced oxidative damage via affecting antioxidant enzyme system in mice.
2017,
Pubmed
Berretta,
Propolis standardized extract (EPP-AF®), an innovative chemically and biologically reproducible pharmaceutical compound for treating wounds.
2012,
Pubmed
Bhargava,
Experimental Evidence for Therapeutic Potentials of Propolis.
2021,
Pubmed
Bjørklund,
The glutathione system in Parkinson's disease and its progression.
2021,
Pubmed
Bloem,
Parkinson's disease.
2021,
Pubmed
Cabral,
Attenuated baroreflex in a Parkinson's disease animal model coincides with impaired activation of non-C1 neurons.
2020,
Pubmed
Clarke,
Mitochondrial respiratory chain disease discrimination by retrospective cohort analysis of blood metabolites.
2013,
Pubmed
Cornara,
Therapeutic Properties of Bioactive Compounds from Different Honeybee Products.
2017,
Pubmed
Cruzat,
Glutamine: Metabolism and Immune Function, Supplementation and Clinical Translation.
2018,
Pubmed
Cuenca-Bermejo,
Cardiac Changes in Parkinson's Disease: Lessons from Clinical and Experimental Evidence.
2021,
Pubmed
Del Rey,
Advances in Parkinson's Disease: 200 Years Later.
2018,
Pubmed
Diniz,
Antioxidant Effect of Standardized Extract of Propolis (EPP-AF®) in Healthy Volunteers: A "Before and After" Clinical Study.
2020,
Pubmed
Do,
Common variants associated with plasma triglycerides and risk for coronary artery disease.
2013,
Pubmed
Dunn,
Dysregulation of glucose metabolism is an early event in sporadic Parkinson's disease.
2014,
Pubmed
Durcan,
Prevalence and duration of non-motor symptoms in prodromal Parkinson's disease.
2019,
Pubmed
Dwivedi,
Glutathione in Brain: Overview of Its Conformations, Functions, Biochemical Characteristics, Quantitation and Potential Therapeutic Role in Brain Disorders.
2020,
Pubmed
Farnier,
Triglycerides and risk of atherosclerotic cardiovascular disease: An update.
2021,
Pubmed
Fu,
Anti-inflammatory effects of BHBA in both in vivo and in vitro Parkinson's disease models are mediated by GPR109A-dependent mechanisms.
2015,
Pubmed
Gall,
alpha-hydroxybutyrate is an early biomarker of insulin resistance and glucose intolerance in a nondiabetic population.
2010,
Pubmed
Goldstein,
Dysautonomia in Parkinson disease.
2014,
Pubmed
Gonzalez-Riano,
Prognostic biomarkers of Parkinson's disease in the Spanish EPIC cohort: a multiplatform metabolomics approach.
2021,
Pubmed
Gonçalves,
Heart Matters: Cardiac Dysfunction and Other Autonomic Changes in Parkinson's Disease.
2022,
Pubmed
Gonçalves,
Propolis as A Potential Disease-Modifying Strategy in Parkinson's Disease: Cardioprotective and Neuroprotective Effects in the 6-OHDA Rat Model.
2020,
Pubmed
Grabska-Kobylecka,
The Presence of Caffeic Acid in Cerebrospinal Fluid: Evidence That Dietary Polyphenols Can Cross the Blood-Brain Barrier in Humans.
2020,
Pubmed
Havelund,
Biomarker Research in Parkinson's Disease Using Metabolite Profiling.
2017,
Pubmed
Heimrich,
Heart Rate Variability Analyses in Parkinson's Disease: A Systematic Review and Meta-Analysis.
2021,
Pubmed
Hori,
The Inhibition of Inflammasome by Brazilian Propolis (EPP-AF).
2013,
Pubmed
Juh,
Different metabolic patterns analysis of Parkinsonism on the 18F-FDG PET.
2004,
Pubmed
Kashiwaya,
D-beta-hydroxybutyrate protects neurons in models of Alzheimer's and Parkinson's disease.
2000,
Pubmed
Kori,
Metabolic Biomarkers and Neurodegeneration: A Pathway Enrichment Analysis of Alzheimer's Disease, Parkinson's Disease, and Amyotrophic Lateral Sclerosis.
2016,
Pubmed
Kumari,
Metabolomic analysis of serum using proton NMR in 6-OHDA experimental PD model and patients with PD.
2020,
Pubmed
Kurek-Górecka,
Structure and antioxidant activity of polyphenols derived from propolis.
2013,
Pubmed
Kuropatnicki,
Historical aspects of propolis research in modern times.
2013,
Pubmed
Laaroussi,
Protective Effect of Honey and Propolis against Gentamicin-Induced Oxidative Stress and Hepatorenal Damages.
2021,
Pubmed
Laufs,
Clinical review on triglycerides.
2020,
Pubmed
Li,
Association Between Heart Rate Variability and Parkinson's Disease: A Meta-analysis.
2021,
Pubmed
Li,
Oral, Nasal, and Gut Microbiota in Parkinson's Disease.
2022,
Pubmed
Lisko,
How can dementia and disability be prevented in older adults: where are we today and where are we going?
2021,
Pubmed
Longinetti,
Heart rate, intelligence in adolescence, and Parkinson's disease later in life.
2021,
Pubmed
Machado,
Brazilian green propolis: anti-inflammatory property by an immunomodulatory activity.
2012,
Pubmed
Majrashi,
β-hydroxybutyric acid attenuates oxidative stress and improves markers of mitochondrial function in the HT-22 hippocampal cell line.
2021,
Pubmed
Mallet,
A metabolic biomarker predicts Parkinson's disease at the early stages in patients and animal models.
2022,
Pubmed
Masini,
A Guide to the Generation of a 6-Hydroxydopamine Mouse Model of Parkinson's Disease for the Study of Non-Motor Symptoms.
2021,
Pubmed
Mastrangelo,
From sample treatment to biomarker discovery: A tutorial for untargeted metabolomics based on GC-(EI)-Q-MS.
2015,
Pubmed
Matsumoto,
Urea cycle disorders-update.
2019,
Pubmed
Mazzetti,
Glutathione transferases and neurodegenerative diseases.
2015,
Pubmed
Moon,
Mitochondrial Dysfunction in Parkinson's Disease.
2015,
Pubmed
Nakajima,
Neuroprotective effects of Brazilian green propolis and its main constituents against oxygen-glucose deprivation stress, with a gene-expression analysis.
2009,
Pubmed
Nakajima,
Water extract of propolis and its main constituents, caffeoylquinic acid derivatives, exert neuroprotective effects via antioxidant actions.
2007,
Pubmed
Nascimento,
Effect of red propolis extract isolated or encapsulated in nanoparticles on the in vitro culture of sheep preantral follicle: Impacts on antrum formation, mitochondrial activity and glutathione levels.
2019,
Pubmed
Nielsen,
Cardiovascular Effects of Treatment With the Ketone Body 3-Hydroxybutyrate in Chronic Heart Failure Patients.
2019,
Pubmed
Nna,
Malaysian Propolis and Metformin Synergistically Mitigate Kidney Oxidative Stress and Inflammation in Streptozotocin-Induced Diabetic Rats.
2021,
Pubmed
Noelker,
The flavanoide caffeic acid phenethyl ester blocks 6-hydroxydopamine-induced neurotoxicity.
NULL,
Pubmed
Norwitz,
The Mechanisms by Which the Ketone Body D-β-Hydroxybutyrate May Improve the Multiple Cellular Pathologies of Parkinson's Disease.
2019,
Pubmed
Oršolić,
Effect of Propolis on Diet-Induced Hyperlipidemia and Atherogenic Indices in Mice.
2019,
Pubmed
Pahlavani,
Molecular and cellular mechanisms of the effects of Propolis in inflammation, oxidative stress and glycemic control in chronic diseases.
2020,
Pubmed
Palma,
Treatment of autonomic dysfunction in Parkinson disease and other synucleinopathies.
2018,
Pubmed
Park,
Association of Parkinson Disease With Risk of Cardiovascular Disease and All-Cause Mortality: A Nationwide, Population-Based Cohort Study.
2020,
Pubmed
Paulino,
Anti-inflammatory effects of a bioavailable compound, Artepillin C, in Brazilian propolis.
2008,
Pubmed
Perlbarg,
Alterations of the nigrostriatal pathway in a 6-OHDA rat model of Parkinson's disease evaluated with multimodal MRI.
2018,
Pubmed
Pirazzini,
A geroscience approach for Parkinson's disease: Conceptual framework and design of PROPAG-AGEING project.
2021,
Pubmed
Przybyłek,
Antibacterial Properties of Propolis.
2019,
Pubmed
Puthanveetil,
Transcriptome analysis of two structurally related flavonoids; Apigenin and Chrysin revealed hypocholesterolemic and ketogenic effects in mouse embryonic fibroblasts.
2021,
Pubmed
Qiu,
Protection against oxidative stress and anti-aging effect in Drosophila of royal jelly-collagen peptide.
2020,
Pubmed
Renguet,
The Regulation of Insulin-Stimulated Cardiac Glucose Transport via Protein Acetylation.
2018,
Pubmed
Rodrigues,
Cardiovascular alterations in rats with Parkinsonism induced by 6-OHDA and treated with Domperidone.
2019,
Pubmed
Roy,
Sodium phenylbutyrate controls neuroinflammatory and antioxidant activities and protects dopaminergic neurons in mouse models of Parkinson's disease.
2012,
Pubmed
Sarabhai,
Hungry for your alanine: when liver depends on muscle proteolysis.
2019,
Pubmed
Scorza,
Cardiac abnormalities in Parkinson's disease and Parkinsonism.
2018,
Pubmed
Seppi,
Update on treatments for nonmotor symptoms of Parkinson's disease-an evidence-based medicine review.
2019,
Pubmed
Sforcin,
Propolis: is there a potential for the development of new drugs?
2011,
Pubmed
Sforcin,
Propolis and the immune system: a review.
2007,
Pubmed
Shao,
Methylmercury can induce Parkinson's-like neurotoxicity similar to 1-methyl-4- phenylpyridinium: a genomic and proteomic analysis on MN9D dopaminergic neuron cells.
2015,
Pubmed
Shen,
Advances in Biosynthesis, Pharmacology, and Pharmacokinetics of Pinocembrin, a Promising Natural Small-Molecule Drug.
2019,
Pubmed
Shimohama,
Disease model: Parkinson's disease.
2003,
Pubmed
Sian-Hulsmann,
The Nigral Coup in Parkinson's Disease by α-Synuclein and Its Associated Rebels.
2021,
Pubmed
Sibson,
TNF-alpha reduces cerebral blood volume and disrupts tissue homeostasis via an endothelin- and TNFR2-dependent pathway.
2002,
Pubmed
Silva,
Cardiovascular and autonomic alterations in rats with Parkinsonism induced by 6-OHDA and treated with L-DOPA.
2015,
Pubmed
Silva,
The Cardiovascular Therapeutic Potential of Propolis-A Comprehensive Review.
2021,
Pubmed
Silva,
Regional, kinetic [(18)F]FDG PET imaging of a unilateral Parkinsonian animal model.
2013,
Pubmed
Simon,
Parkinson Disease Epidemiology, Pathology, Genetics, and Pathophysiology.
2020,
Pubmed
Smeyne,
Glutathione metabolism and Parkinson's disease.
2013,
Pubmed
Sun,
Identification and Determination of Seven Phenolic Acids in Brazilian Green Propolis by UPLC-ESI-QTOF-MS and HPLC.
2019,
Pubmed
Takeda,
A water-soluble derivative of propolis augments the cytotoxic activity of natural killer cells.
2018,
Pubmed
Thobois,
What a neurologist should know about PET and SPECT functional imaging for parkinsonism: A practical perspective.
2019,
Pubmed
Ueda,
Propolis extract promotes translocation of glucose transporter 4 and glucose uptake through both PI3K- and AMPK-dependent pathways in skeletal muscle.
2013,
Pubmed
Valença,
Portuguese propolis disturbs glycolytic metabolism of human colorectal cancer in vitro.
2013,
Pubmed
Vanitallie,
Treatment of Parkinson disease with diet-induced hyperketonemia: a feasibility study.
2005,
Pubmed
Zhang,
Caffeic acid reduces A53T α-synuclein by activating JNK/Bcl-2-mediated autophagy in vitro and improves behaviour and protects dopaminergic neurons in a mouse model of Parkinson's disease.
2019,
Pubmed
Zhang,
Autonomic Dysfunctions in Parkinson's Disease: Prevalence, Clinical Characteristics, Potential Diagnostic Markers, and Treatment.
2020,
Pubmed
de Sousa,
A validated reverse-phase HPLC analytical method for the quantification of phenolic compounds in Baccharis dracunculifolia.
2009,
Pubmed
van Wamelen,
Stress and cortisol in Parkinson's disease.
2020,
Pubmed