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Characterization of Gut Microbiome Composition in Patients with Triple-Negative Breast Cancer Treated with Neoadjuvant Chemotherapy.
Vernaci G
,
Savarino EV
,
Patuzzi I
,
Facchin S
,
Zingone F
,
Massa D
,
Faggioni G
,
Giarratano T
,
Miglietta F
,
Griguolo G
,
Fassan M
,
Lo Mele M
,
Gasparini E
,
Bisagni G
,
Guarneri V
,
Dieci MV
.
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INTRODUCTION: Patients with triple-negative breast cancer (TNBC) achieving a pathological complete response (pCR) after neoadjuvant chemotherapy have a better event-free survival. The role of gut microbiome in early TNBC is underexplored.
METHODS: Microbiome was analyzed by 16SrRNA sequencing.
RESULTS: Twenty-five patients with TNBC treated with neoadjuvant anthracycline/taxane-based chemotherapy were included. Fifty-six percent achieved a pCR. Fecal samples were collected before (t0), at 1 (t1), and 8 weeks (t2) from chemotherapy. Overall, 68/75 samples (90.7%) were suitable for microbiome analysis. At t0, pCR group showed a significantly higher α-diversity as compared with no-pCR, (P = .049). The PERMANOVA test on β-diversity highlighted a significant difference in terms of BMI (P = 0.039). Among patients with available matched samples at t0 and t1, no significant variation in microbiome composition was reported over time.
CONCLUSIONS: Fecal microbiome analysis in early TNBC is feasible and deserves further investigation in order to unravel its complex correlation with immunity and cancer.
An,
Anti-Colorectal Cancer Effects of Probiotic-Derived p8 Protein.
2019, Pubmed
An,
Anti-Colorectal Cancer Effects of Probiotic-Derived p8 Protein.
2019,
Pubmed
Bolyen,
Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2.
2019,
Pubmed
Callahan,
DADA2: High-resolution sample inference from Illumina amplicon data.
2016,
Pubmed
Chen,
GMPR: A robust normalization method for zero-inflated count data with application to microbiome sequencing data.
2018,
Pubmed
Cortazar,
Pathological complete response and long-term clinical benefit in breast cancer: the CTNeoBC pooled analysis.
2014,
Pubmed
DeSantis,
Greengenes, a chimera-checked 16S rRNA gene database and workbench compatible with ARB.
2006,
Pubmed
Denkert,
Tumour-infiltrating lymphocytes and prognosis in different subtypes of breast cancer: a pooled analysis of 3771 patients treated with neoadjuvant therapy.
2018,
Pubmed
Foulkes,
Triple-negative breast cancer.
2010,
Pubmed
Gopalakrishnan,
Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients.
2018,
Pubmed
Heshiki,
Predictable modulation of cancer treatment outcomes by the gut microbiota.
2020,
Pubmed
Iida,
Commensal bacteria control cancer response to therapy by modulating the tumor microenvironment.
2013,
Pubmed
Ivanov,
Intestinal commensal microbes as immune modulators.
2012,
Pubmed
Martin,
MODELING MICROBIAL ABUNDANCES AND DYSBIOSIS WITH BETA-BINOMIAL REGRESSION.
2020,
Pubmed
Matson,
The commensal microbiome is associated with anti-PD-1 efficacy in metastatic melanoma patients.
2018,
Pubmed
McDonald,
American Gut: an Open Platform for Citizen Science Microbiome Research.
2018,
Pubmed
Milani,
Assessing the fecal microbiota: an optimized ion torrent 16S rRNA gene-based analysis protocol.
2013,
Pubmed
Park,
Targeting the gut and tumor microbiota in cancer.
2022,
Pubmed
Peterson,
Management of oral and gastrointestinal mucosal injury: ESMO Clinical Practice Guidelines for diagnosis, treatment, and follow-up.
2015,
Pubmed
Routy,
Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors.
2018,
Pubmed
Salgado,
The evaluation of tumor-infiltrating lymphocytes (TILs) in breast cancer: recommendations by an International TILs Working Group 2014.
2015,
Pubmed
Sankaranarayanan,
Screening of Human Gut Bacterial Culture Collection Identifies Species That Biotransform Quercetin into Metabolites with Anticancer Properties.
2021,
Pubmed
Savas,
Clinical relevance of host immunity in breast cancer: from TILs to the clinic.
2016,
Pubmed
Singh,
Influence of diet on the gut microbiome and implications for human health.
2017,
Pubmed
Sivan,
Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy.
2015,
Pubmed
Spencer,
Dietary fiber and probiotics influence the gut microbiome and melanoma immunotherapy response.
2021,
Pubmed
Terrisse,
Intestinal microbiota influences clinical outcome and side effects of early breast cancer treatment.
2021,
Pubmed
Viaud,
The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide.
2013,
Pubmed
Vinderola,
Effects of the oral administration of the exopolysaccharide produced by Lactobacillus kefiranofaciens on the gut mucosal immunity.
2006,
Pubmed
Wan,
Fermentation supernatants of Lactobacillus delbrueckii inhibit growth of human colon cancer cells and induce apoptosis through a caspase 3-dependent pathway.
2014,
Pubmed
West,
Immunotherapy Not Working? Check Your Microbiota.
2015,
Pubmed
Zitvogel,
Microbiome and Anticancer Immunosurveillance.
2016,
Pubmed
de Moreno de Leblanc,
Yogurt feeding inhibits promotion and progression of experimental colorectal cancer.
2004,
Pubmed
