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Hematol Transfus Cell Ther
2023 Jan 01;453:324-329. doi: 10.1016/j.htct.2022.05.005.
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Lower expression of NOTCH components in peripheral blood mononuclear cells of allogeneic hematopoietic cell transplant patients.
Colella MP
,
Morini BC
,
Niemann F
,
Lopes MR
,
Saad SO
,
Favaro P
.
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INTRODUCTION: Chronic graft-versus-host disease (cGvHD) not only remains the main cause of late mortality after allogeneic hematopoietic cell transplant, but also has the capacity of causing severe organ impairment in those who survive. The Notch, a highly conserved ligand-receptor pathway, is involved in many immunological processes, including inflammatory and regulatory responses. Recently, mouse models have shown that the blockage of canonical Notch signaling prevents GvHD.
OBJECTIVE AND METHOD: Due to the lack of data on the Notch pathway in human chronic GvHD, we sought to study the expression of NOTCH components in primary samples of patients who received allo-HCT and presented active cGvHD or a long-term clinical tolerance to cGvHD.
RESULTS: Our results showed a significantly lower expression of NOTCH components in both groups that received allo-HCT, independently of their cGvHD status, when compared to healthy controls.
CONCLUSION: Moreover, there were no differences in gene expression levels between the active cGvHD and clinically tolerant groups. To our knowledge, this is one of the first studies performed in human primary samples and our data indicate that much remains to be learned regarding NOTCH signaling as a new regulator of GvHD.
Clift,
Allogeneic marrow transplantation in patients with acute myeloid leukemia in first remission: a randomized trial of two irradiation regimens.
1990, Pubmed
Clift,
Allogeneic marrow transplantation in patients with acute myeloid leukemia in first remission: a randomized trial of two irradiation regimens.
1990,
Pubmed
Cooke,
The Biology of Chronic Graft-versus-Host Disease: A Task Force Report from the National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease.
2017,
Pubmed
Di Ianni,
NOTCH and Graft-Versus-Host Disease.
2018,
Pubmed
Durai,
Functions of Murine Dendritic Cells.
2016,
Pubmed
Jagasia,
National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: I. The 2014 Diagnosis and Staging Working Group report.
2015,
Pubmed
Konya,
Innate lymphoid cells in graft-versus-host disease.
2015,
Pubmed
Lee,
Chronic graft-versus-host disease.
2003,
Pubmed
Lee,
Severity of chronic graft-versus-host disease: association with treatment-related mortality and relapse.
2002,
Pubmed
Maekawa,
Notch2 integrates signaling by the transcription factors RBP-J and CREB1 to promote T cell cytotoxicity.
2008,
Pubmed
Mickelson,
Comparison of donor chimerism following myeloablative and nonmyeloablative allogeneic hematopoietic SCT.
2011,
Pubmed
Morecki,
Immune reconstitution following allogeneic stem cell transplantation in recipients conditioned by low intensity vs myeloablative regimen.
2001,
Pubmed
Poe,
An aberrant NOTCH2-BCR signaling axis in B cells from patients with chronic GVHD.
2017,
Pubmed
Radojcic,
Notch Signaling and Alloreactivity.
2016,
Pubmed
Radojcic,
Notch signaling mediated by Delta-like ligands 1 and 4 controls the pathogenesis of chronic GVHD in mice.
2018,
Pubmed
Radtke,
Regulation of innate and adaptive immunity by Notch.
2013,
Pubmed
Rosenfeld,
Reference values for blood count laboratory tests in the Brazilian adult population, National Health Survey.
2019,
Pubmed
Sandy,
T cell-specific notch inhibition blocks graft-versus-host disease by inducing a hyporesponsive program in alloreactive CD4+ and CD8+ T cells.
2013,
Pubmed
Schroeder,
Mouse models of graft-versus-host disease: advances and limitations.
2011,
Pubmed
Shang,
Role of Notch signaling in regulating innate immunity and inflammation in health and disease.
2016,
Pubmed
Thomas,
Notch activity synergizes with B-cell-receptor and CD40 signaling to enhance B-cell activation.
2007,
Pubmed
Tran,
Blockade of individual Notch ligands and receptors controls graft-versus-host disease.
2013,
Pubmed
Vanderbeck,
Notch signaling at the crossroads of innate and adaptive immunity.
2021,
Pubmed
Vigouroux,
Induction of antigen-specific regulatory T cells following overexpression of a Notch ligand by human B lymphocytes.
2003,
Pubmed
Yu,
Dendritic Cell Regulation of Graft-Vs.-Host Disease: Immunostimulation and Tolerance.
2019,
Pubmed
Yvon,
Overexpression of the Notch ligand, Jagged-1, induces alloantigen-specific human regulatory T cells.
2003,
Pubmed
Zhang,
Notch signaling is a critical regulator of allogeneic CD4+ T-cell responses mediating graft-versus-host disease.
2011,
Pubmed