Click
here to close Hello! We notice that
you are using Internet Explorer, which is not supported by Echinobase
and may cause the site to display incorrectly. We suggest using a
current version of Chrome,
FireFox,
or Safari.
Int J Mol Sci
2023 Jan 29;243:. doi: 10.3390/ijms24032553.
Show Gene links
Show Anatomy links
Polysaccharides from Holothuria leucospilota Relieve Loperamide-Induced Constipation Symptoms in Mice.
Wang Z
,
Shi Y
,
Zeng S
,
Zheng Y
,
Wang H
,
Liao H
,
Song J
,
Zhang X
,
Cao J
,
Li C
.
???displayArticle.abstract???
A vital bioactive component of marine resources is Holothuria leucospilota polysaccharides (HLP). This study examined whether HLP could regulate intestinal flora to treat loperamide-induced constipation. Constipated mice showed signs of prolonged defecation (up by 60.79 min) and a reduced number of bowel movements and pellet water content (decreased by 12.375 and 11.77%, respectively). The results showed that HLP treatment reduced these symptoms, reversed the changes in related protein expression levels in the colon, and regulated the levels of active peptides associated with the gastrointestinal tract in constipated mice, which significantly improved water-electrolyte metabolism and enhanced gastrointestinal motility. Meanwhile, it was found that intestinal barrier damage was reduced and the inflammatory response was inhibited through histopathology and immunohistochemistry. As a means to further relieve constipation symptoms, treatment with low, medium, and high HLP concentrations increased the total short-chain fatty acid (SCFA) content in the intestine of constipated mice by 62.60 μg/g, 138.91 μg/g, and 126.51 μg/g, respectively. Moreover, an analysis of the intestinal flora's gene for 16S rRNA suggested that the intestinal microbiota was improved through HLP treatment, which is relevant to the motivation for the production of SCFAs. In summary, it was demonstrated that HLP reduced loperamide-induced constipation in mice.
Bharucha,
Mechanisms, Evaluation, and Management of Chronic Constipation.
2020, Pubmed
Bharucha,
Mechanisms, Evaluation, and Management of Chronic Constipation.
2020,
Pubmed
Bohr,
A group-specific PCR assay for the detection of Helicobacteraceae in human gut.
2002,
Pubmed
Burns,
Interstitial cells of Cajal in the guinea-pig gastrointestinal tract as revealed by c-Kit immunohistochemistry.
1997,
Pubmed
Chai,
Role of stem cell growth factor/c-Kit in the pathogenesis of irritable bowel syndrome.
2017,
Pubmed
Eor,
Laxative effect of probiotic chocolate on loperamide-induced constipation in rats.
2019,
Pubmed
Hellmich,
Human colorectal cancers express a constitutively active cholecystokinin-B/gastrin receptor that stimulates cell growth.
2000,
Pubmed
Heymen,
Biofeedback treatment of constipation: a critical review.
2003,
Pubmed
Hsieh,
Treatment of constipation in older adults.
2005,
Pubmed
Hu,
Protective effect of mulberry (Morus atropurpurea) fruit against diphenoxylate-induced constipation in mice through the modulation of gut microbiota.
2019,
Pubmed
Hwang,
Substance-P Ameliorates Dextran Sodium Sulfate-Induced Intestinal Damage by Preserving Tissue Barrier Function.
2018,
Pubmed
Icaza-Chávez,
[Gut microbiota in health and disease].
2013,
Pubmed
Jiang,
Effect of Durio zibethinus rind polysaccharide on functional constipation and intestinal microbiota in rats.
2020,
Pubmed
Khotimchenko,
Pharmacological Potential of Sea Cucumbers.
2018,
Pubmed
,
Echinobase
Knowles,
Surgical management of constipation.
2009,
Pubmed
Krausova,
Plectin ensures intestinal epithelial integrity and protects colon against colitis.
2021,
Pubmed
Li,
Effect of Lactobacillus plantarum NCU116 on loperamide-induced constipation in mice.
2015,
Pubmed
Lu,
Holothuria Leucospilota polysaccharides alleviate hyperlipidemia via alteration of lipid metabolism and inflammation-related gene expression.
2022,
Pubmed
,
Echinobase
Natividad,
Modulation of intestinal barrier by intestinal microbiota: pathological and therapeutic implications.
2013,
Pubmed
Ohkusa,
Gut Microbiota and Chronic Constipation: A Review and Update.
2019,
Pubmed
Rao,
Diagnosis and management of chronic constipation in adults.
2016,
Pubmed
Shi,
Effect and mechanism of functional compound fruit drink on gut microbiota in constipation mice.
2023,
Pubmed
Sibai,
Microbiome and Longevity: High Abundance of Longevity-Linked Muribaculaceae in the Gut of the Long-Living Rodent Spalax leucodon.
2020,
Pubmed
Silberstein,
Functional characterization and localization of AQP3 in the human colon.
1999,
Pubmed
Stojanov,
The Influence of Probiotics on the Firmicutes/Bacteroidetes Ratio in the Treatment of Obesity and Inflammatory Bowel disease.
2020,
Pubmed
Sumida,
Constipation and risk of death and cardiovascular events.
2019,
Pubmed
Sun,
Perilla frutescens Leaf Alters the Rumen Microbial Community of Lactating Dairy Cows.
2019,
Pubmed
Takaki,
Gut pacemaker cells: the interstitial cells of Cajal (ICC).
2003,
Pubmed
Vinolo,
Regulation of inflammation by short chain fatty acids.
2011,
Pubmed
Wald,
Update on the Management of Constipation.
2019,
Pubmed
Wang,
Beneficial Effects of Holothuria leucospilota Polysaccharides on Fermentability In Vivo and In Vitro.
2021,
Pubmed
,
Echinobase
Wang,
The effect of microbial composition and proteomic on improvement of functional constipation by Chrysanthemum morifolium polysaccharide.
2021,
Pubmed
Yamamoto,
Disturbed gastrointestinal motility and decreased interstitial cells of Cajal in diabetic db/db mice.
2008,
Pubmed
Yang,
Dietary synbiotic ameliorates constipation through the modulation of gut microbiota and its metabolic function.
2021,
Pubmed
Yang,
Research Progress on the Protective Effect of Brown Algae-Derived Polysaccharides on Metabolic Diseases and Intestinal Barrier Injury.
2022,
Pubmed
Yuan,
Holothuria Leucospilota Polysaccharides Ameliorate Hyperlipidemia in High-Fat Diet-Induced Rats via Short-Chain Fatty Acids Production and Lipid Metabolism Regulation.
2019,
Pubmed
,
Echinobase
Zhang,
Prevention of loperamide induced constipation in mice by KGM and the mechanisms of different gastrointestinal tract microbiota regulation.
2021,
Pubmed
Zhao,
A sea cucumber (Holothuria leucospilota) polysaccharide improves the gut microbiome to alleviate the symptoms of type 2 diabetes mellitus in Goto-Kakizaki rats.
2020,
Pubmed
,
Echinobase
Zhao,
Holothuria leucospilota Polysaccharides Improve Immunity and the Gut Microbiota in Cyclophosphamide-Treated Immunosuppressed Mice.
2023,
Pubmed
,
Echinobase
Zhao,
Saturated long-chain fatty acid-producing bacteria contribute to enhanced colonic motility in rats.
2018,
Pubmed
den Besten,
The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism.
2013,
Pubmed
