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Int J Mol Sci
2023 Feb 14;244:. doi: 10.3390/ijms24043823.
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Effects of Oncolytic Vaccinia Viruses Harboring Different Marine Lectins on Hepatocellular Carcinoma Cells.
Zhou Y
,
Wang Q
,
Ying Q
,
Zhang X
,
Chen K
,
Ye T
,
Li G
.
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Oncolytic viruses are being developed as novel strategies for cancer therapy. Our previous studies have shown that vaccinia viruses armed with marine lectins improved the antitumor efficacy in diverse cancer types. The objective of this study was to assess the cytotoxic effects of oncoVV harboring Tachypleus tridentatus lectin (oncoVV-TTL), Aphrocallistes vastus lectin (oncoVV-AVL), white-spotted charr lectin (oncoVV-WCL), and Asterina pectinifera lectin (oncoVV-APL) on HCC. Our data revealed that the effects of recombinant viruses on Hep-3B cells were oncoVV-AVL > oncoVV-APL > oncoVV-TTL > oncoVV-WCL; oncoVV-AVL showed stronger cytotoxicity than oncoVV-APL, while oncoVV-TTL/WCL had no effect on cell killing in Huh7 cells, and PLC/PRF/5 cells exhibited sensitivity to oncoVV-AVL/TTL but not to oncoVV-APL/WCL. The cytotoxicity of oncoVV-lectins could be enhanced by apoptosis and replication in a cell-type-dependent manner. Further research revealed that AVL may mediate various pathways, including MAPK, Hippo, PI3K, lipid metabolism, and androgen pathways through AMPK crosstalk, to promote oncoVV replication in HCC in a cell-dependent manner. OncoVV-APL replication could be affected by AMPK/Hippo/lipid metabolism pathways in Hep-3B cells, AMPK/Hippo/PI3K/androgen pathways in Huh7 cells, and AMPK/Hippo pathways in PLC/PRF/5 cells. OncoVV-WCL replication was also multi-mechanistic, which could be affected by AMPK/JNK/lipid metabolism pathways in Hep-3B cells, AMPK/Hippo/androgen pathways in Huh7 cells, and AMPK/JNK/Hippo pathways in PLC/PRF/5 cells. In addition, AMPK and lipid metabolism pathways may play critical roles in oncoVV-TTL replication in Hep-3B cells, and oncoVV-TTL replication in Huh7 cells may depend on AMPK/PI3K/androgen pathways. This study provides evidence for the application of oncolytic vaccinia viruses in hepatocellular carcinoma.
TGY23D060001 Zhejiang Provincial Natural Science Foundation, 81972281 National Natural Science Foundation of China, 11612932612101 Zhejiang Sci-Tech University Foundation
Aranda,
Capsaicin affects the structure and phase organization of phospholipid membranes.
1995, Pubmed
Aranda,
Capsaicin affects the structure and phase organization of phospholipid membranes.
1995,
Pubmed
Bonnardel,
Structural Database for Lectins and the UniLectin Web Platform.
2020,
Pubmed
Catanzaro,
Antitumor Potential of Marine and Freshwater Lectins.
2019,
Pubmed
Chan,
Oncolytic Poxviruses.
2014,
Pubmed
Chennaiah,
One-Step TEMPO-Catalyzed and Water-Mediated Stereoselective Conversion of Glycals into 2-Azido-2-deoxysugars with a PIFA-Trimethylsilyl Azide Reagent System.
2018,
Pubmed
Cheung,
Marine lectins and their medicinal applications.
2015,
Pubmed
De Mol,
EPI-001, A Compound Active against Castration-Resistant Prostate Cancer, Targets Transactivation Unit 5 of the Androgen Receptor.
2016,
Pubmed
Dunn,
HijAkt: The PI3K/Akt pathway in virus replication and pathogenesis.
2012,
Pubmed
Ferlay,
Cancer statistics for the year 2020: An overview.
2021,
Pubmed
Fujii,
A lectin from the mussel Mytilus galloprovincialis has a highly novel primary structure and induces glycan-mediated cytotoxicity of globotriaosylceramide-expressing lymphoma cells.
2012,
Pubmed
Fukuhara,
Oncolytic virus therapy: A new era of cancer treatment at dawn.
2016,
Pubmed
Garcia,
Hippo Signaling Pathway Has a Critical Role in Zika Virus Replication and in the Pathogenesis of Neuroinflammation.
2020,
Pubmed
Gilles,
Hepatocellular Carcinoma.
2022,
Pubmed
Greseth,
De novo fatty acid biosynthesis contributes significantly to establishment of a bioenergetically favorable environment for vaccinia virus infection.
2014,
Pubmed
Hasan,
MytiLec, a Mussel R-Type Lectin, Interacts with Surface Glycan Gb3 on Burkitt's Lymphoma Cells to Trigger Apoptosis through Multiple Pathways.
2015,
Pubmed
Hayashi,
Active Targeting to Osteosarcoma Cells and Apoptotic Cell Death Induction by the Novel Lectin Eucheuma serra Agglutinin Isolated from a Marine Red Alga.
2012,
Pubmed
Hung,
Purification, characterization and biological effect of lectin from the marine sponge Stylissa flexibilis (Lévi, 1961).
2018,
Pubmed
Jhawar,
Oncolytic Viruses-Natural and Genetically Engineered Cancer Immunotherapies.
2017,
Pubmed
Jiang,
Oncolytic Vaccinia Virus Harboring Aphrocallistes vastus Lectin Inhibits the Growth of Hepatocellular Carcinoma Cells.
2022,
Pubmed
Kaufman,
Oncolytic viruses: a new class of immunotherapy drugs.
2015,
Pubmed
Kumar,
Role of MAPK/MNK1 signaling in virus replication.
2018,
Pubmed
Kurapati,
Role of the JNK Pathway in Varicella-Zoster Virus Lytic Infection and Reactivation.
2017,
Pubmed
LaBarre,
Improvements in methods for calculating virus titer estimates from TCID50 and plaque assays.
2001,
Pubmed
Lei,
Metformin targets multiple signaling pathways in cancer.
2017,
Pubmed
Leung,
Capsaicin as an anti-obesity drug.
2014,
Pubmed
Li,
Tachypleus tridentatus Lectin Enhances Oncolytic Vaccinia Virus Replication to Suppress In Vivo Hepatocellular Carcinoma Growth.
2018,
Pubmed
Liu,
Treatment of Liver Cancer.
2015,
Pubmed
Marques,
Antibacterial activity of a new lectin isolated from the marine sponge Chondrilla caribensis.
2018,
Pubmed
Meng,
Mechanisms of Hippo pathway regulation.
2016,
Pubmed
Moser,
A kinome RNAi screen identified AMPK as promoting poxvirus entry through the control of actin dynamics.
2010,
Pubmed
Ni,
Oncolytic Vaccinia Virus Harboring Aphrocallistes vastus Lectin Inhibits the Growth of Cervical Cancer Cells Hela S3.
2021,
Pubmed
Omokawa,
In vitro and in vivo anti-tumor effects of novel Span 80 vesicles containing immobilized Eucheuma serra agglutinin.
2010,
Pubmed
Rodrigues Mantuano,
Tumor-associated carbohydrates and immunomodulatory lectins as targets for cancer immunotherapy.
2020,
Pubmed
Rodríguez,
Raf/MEK/ERK pathway activation is required for Junín virus replication.
2014,
Pubmed
Sharma,
Effects of Capsaicin on Biomimetic Membranes.
2019,
Pubmed
Sharon,
Lectins: carbohydrate-specific reagents and biological recognition molecules.
2007,
Pubmed
Simile,
Targeted Therapies in Cholangiocarcinoma: Emerging Evidence from Clinical Trials.
2019,
Pubmed
Smith,
The formation and function of extracellular enveloped vaccinia virus.
2002,
Pubmed
Soares,
Activation of the PI3K/Akt pathway early during vaccinia and cowpox virus infections is required for both host survival and viral replication.
2009,
Pubmed
Sugahara,
The cytotoxic effect of Eucheuma serra agglutinin (ESA) on cancer cells and its application to molecular probe for drug delivery system using lipid vesicles.
2001,
Pubmed
Tian,
Enhancement of hepatitis B virus replication by androgen and its receptor in mice.
2012,
Pubmed
Torres-Domínguez,
Poxvirus oncolytic virotherapy.
2019,
Pubmed
Vázquez,
Identification of functional domains in the 14-kilodalton envelope protein (A27L) of vaccinia virus.
1999,
Pubmed
Vázquez,
The vaccinia virus 14-kilodalton (A27L) fusion protein forms a triple coiled-coil structure and interacts with the 21-kilodalton (A17L) virus membrane protein through a C-terminal alpha-helix.
1998,
Pubmed
Wang,
Oncolytic Vaccinia Virus Expressing White-Spotted Charr Lectin Regulates Antiviral Response in Tumor Cells and Inhibits Tumor Growth In Vitro and In Vivo.
2021,
Pubmed
Wang,
AMPK modulates Hippo pathway activity to regulate energy homeostasis.
2015,
Pubmed
Wang,
White Spot Syndrome Virus Establishes a Novel IE1/JNK/c-Jun Positive Feedback Loop to Drive Replication.
2020,
Pubmed
Wang,
The Hippo Pathway and Viral Infections.
2019,
Pubmed
Wang,
YAP antagonizes innate antiviral immunity and is targeted for lysosomal degradation through IKKɛ-mediated phosphorylation.
2017,
Pubmed
Wu,
Oncolytic Vaccinia Virus Expressing Aphrocallistes vastus Lectin as a Cancer Therapeutic Agent.
2019,
Pubmed
Wu,
Hepatitis B virus X protein mediates yes-associated protein 1 upregulation in hepatocellular carcinoma.
2016,
Pubmed
Wu,
Host Sex Steroids Interact With Virus Infection: New Insights Into Sex Disparity in Infectious Diseases.
2021,
Pubmed
Yan,
Structure and Physiological Regulation of AMPK.
2018,
Pubmed
Yang,
A global view of hepatocellular carcinoma: trends, risk, prevention and management.
2019,
Pubmed
Zhang,
Combinational strategies of metformin and chemotherapy in cancers.
2016,
Pubmed
Zhang,
Hippo signalling governs cytosolic nucleic acid sensing through YAP/TAZ-mediated TBK1 blockade.
2017,
Pubmed
Zheng,
Oncolytic Vaccinia Virus Carrying Aphrocallistes vastus Lectin (oncoVV-AVL) Enhances Inflammatory Response in Hepatocellular Carcinoma Cells.
2022,
Pubmed
Zhou,
A Comparative Study of Oncolytic Vaccinia Viruses Harboring Different Marine Lectins in Breast Cancer Cells.
2023,
Pubmed
,
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