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Sci Rep
2023 Mar 23;131:4804. doi: 10.1038/s41598-023-31722-5.
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Antiviral activity of marine sulfated glycans against pathogenic human coronaviruses.
Zoepfl M
,
Dwivedi R
,
Kim SB
,
McVoy MA
,
Pomin VH
.
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Great interest exists towards the discovery and development of broad-spectrum antivirals. This occurs due to the frequent emergence of new viruses which can also eventually lead to pandemics. A reasonable and efficient strategy to develop new broad-spectrum antivirals relies on targeting a common molecular player of various viruses. Heparan sulfate is a sulfated glycosaminoglycan present on the surface of cells which plays a key role as co-receptor in many virus infections. In previous work, marine sulfated glycans (MSGs) were identified as having antiviral activities. Their mechanism of action relies primarily on competitive inhibition of virion binding to heparan sulfate, preventing virus attachment to the cell surface prior to entry. In the current work we used pseudotyped lentivirus particles to investigate in a comparative fashion the inhibitory properties of five structurally defined MSGs against SARS-CoV-1, SARS-CoV-2, MERS-CoV, and influenza A virus (IAV). MSGs include the disaccharide-repeating sulfated galactan from the red alga Botryocladia occidentalis, the tetrasaccharide-repeating sulfated fucans from the sea urchin Lytechinus variegatus and from the sea cucumber Isostichopus badionotus, and the two marine fucosylated chondroitin sulfates from the sea cucumbers I. badionotus and Pentacta pygmaea. Results indicate specificity of action against SARS-CoV-1 and SARS-CoV-2. Curiously, the MSGs showed decreased inhibitory potencies against MERS-CoV and negligible action against IAV. Among the five MSGs, the two sulfated fucans here studied deserve further attention since they have the lowest anticoagulant effects but still present potent and selective antiviral properties.
Al-Tawfiq,
Middle East Respiratory Syndrome-coronavirus infection: an overview.
2013, Pubmed
Al-Tawfiq,
Middle East Respiratory Syndrome-coronavirus infection: an overview.
2013,
Pubmed
Andrew,
Marine sulfated polysaccharides as potential antiviral drug candidates to treat Corona Virus disease (COVID-19).
2021,
Pubmed
Baba,
Sulfated polysaccharides are potent and selective inhibitors of various enveloped viruses, including herpes simplex virus, cytomegalovirus, vesicular stomatitis virus, and human immunodeficiency virus.
1988,
Pubmed
Badani,
Peptide entry inhibitors of enveloped viruses: the importance of interfacial hydrophobicity.
2014,
Pubmed
Bezerra,
Conformational properties of l-fucose and the tetrasaccharide building block of the sulfated l-fucan from Lytechinus variegatus.
2020,
Pubmed
,
Echinobase
Cagno,
Heparan Sulfate Proteoglycans and Viral Attachment: True Receptors or Adaptation Bias?
2019,
Pubmed
Chen,
Sequence determination and anticoagulant and antithrombotic activities of a novel sulfated fucan isolated from the sea cucumber Isostichopus badionotus.
2012,
Pubmed
,
Echinobase
Clausen,
SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2.
2020,
Pubmed
Crawford,
Protocol and Reagents for Pseudotyping Lentiviral Particles with SARS-CoV-2 Spike Protein for Neutralization Assays.
2020,
Pubmed
Dacon,
Broadly neutralizing antibodies target the coronavirus fusion peptide.
2022,
Pubmed
Dwivedi,
Structural and kinetic analyses of holothurian sulfated glycans suggest potential treatment for SARS-CoV-2 infection.
2021,
Pubmed
,
Echinobase
Dwivedi,
Anti-SARS-CoV-2 and anticoagulant properties of Pentacta pygmaea fucosylated chondroitin sulfate depend on high molecular weight structures.
2023,
Pubmed
,
Echinobase
Farias,
Structure and anticoagulant activity of sulfated galactans. Isolation of a unique sulfated galactan from the red algae Botryocladia occidentalis and comparison of its anticoagulant action with that of sulfated galactans from invertebrates.
2000,
Pubmed
Gasbarri,
SARS-CoV-2 Inhibition by Sulfonated Compounds.
2020,
Pubmed
Hao,
Marine glycan-based antiviral agents in clinical or preclinical trials.
2019,
Pubmed
Hayashi,
Calcium spirulan, an inhibitor of enveloped virus replication, from a blue-green alga Spirulina platensis.
1996,
Pubmed
Hoffmann,
Polymers Inspired by Heparin and Heparan Sulfate for Viral Targeting.
2022,
Pubmed
Kim,
Fractionation of sulfated galactan from the red alga Botryocladia occidentalis separates its anticoagulant and anti-SARS-CoV-2 properties.
2022,
Pubmed
Kim,
Characterization of heparin and severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) spike glycoprotein binding interactions.
2020,
Pubmed
Kim,
In vitro inhibition of influenza A virus infection by marine microalga-derived sulfated polysaccharide p-KG03.
2012,
Pubmed
Lang,
Inhibition of SARS pseudovirus cell entry by lactoferrin binding to heparan sulfate proteoglycans.
2011,
Pubmed
Li,
Pandemic and Avian Influenza A Viruses in Humans: Epidemiology, Virology, Clinical Characteristics, and Treatment Strategy.
2017,
Pubmed
Li,
Identification of sialic acid-binding function for the Middle East respiratory syndrome coronavirus spike glycoprotein.
2017,
Pubmed
Li,
Fucosylated chondroitin sulfate oligosaccharides exert anticoagulant activity by targeting at intrinsic tenase complex with low FXII activation: Importance of sulfation pattern and molecular size.
2017,
Pubmed
,
Echinobase
Luo,
Influenza virus entry.
2012,
Pubmed
Maya,
Indirect COVID-19 health effects and potential mitigating interventions: Cost-effectiveness framework.
2022,
Pubmed
Melo,
Antithrombin-mediated anticoagulant activity of sulfated polysaccharides: different mechanisms for heparin and sulfated galactans.
2004,
Pubmed
Melo,
An algal sulfated galactan has an unusual dual effect on venous thrombosis due to activation of factor XII and inhibition of the coagulation proteases.
2008,
Pubmed
Mulloy,
Sulfated fucans from echinoderms have a regular tetrasaccharide repeating unit defined by specific patterns of sulfation at the 0-2 and 0-4 positions.
1994,
Pubmed
,
Echinobase
Pacheco,
Different antithrombotic mechanisms among glycosaminoglycans revealed with a new fucosylated chondroitin sulfate from an echinoderm.
2000,
Pubmed
,
Echinobase
Paiardi,
The binding of heparin to spike glycoprotein inhibits SARS-CoV-2 infection by three mechanisms.
2022,
Pubmed
Panneer,
Health, Economic and Social Development Challenges of the COVID-19 Pandemic: Strategies for Multiple and Interconnected Issues.
2022,
Pubmed
Patel,
High efficiency gene transfer to airways of mice using influenza hemagglutinin pseudotyped lentiviral vectors.
2013,
Pubmed
Peng,
Outbreak of COVID-19: An emerging global pandemic threat.
2020,
Pubmed
Pomin,
Fucanomics and galactanomics: marine distribution, medicinal impact, conceptions, and challenges.
2012,
Pubmed
Pomin,
Marine Non-Glycosaminoglycan Sulfated Glycans as Potential Pharmaceuticals.
2015,
Pubmed
Pomin,
Antimicrobial Sulfated Glycans: Structure and Function.
2017,
Pubmed
Pomin,
Fucanomics and galactanomics: current status in drug discovery, mechanisms of action and role of the well-defined structures.
2012,
Pubmed
Pomin,
How to analyze the anticoagulant and antithrombotic mechanisms of action in fucanome and galactanome?
2014,
Pubmed
Pomin,
Specific sulfation and glycosylation-a structural combination for the anticoagulation of marine carbohydrates.
2014,
Pubmed
,
Echinobase
Pomin,
Selective cleavage and anticoagulant activity of a sulfated fucan: stereospecific removal of a 2-sulfate ester from the polysaccharide by mild acid hydrolysis, preparation of oligosaccharides, and heparin cofactor II-dependent anticoagulant activity.
2005,
Pubmed
,
Echinobase
Pomin,
Current structural biology of the heparin interactome.
2015,
Pubmed
Qureshi,
AVPdb: a database of experimentally validated antiviral peptides targeting medically important viruses.
2014,
Pubmed
Raj,
Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC.
2013,
Pubmed
Ramos-MartÃnez,
Heparan Sulfate and Sialic Acid in Viral Attachment: Two Sides of the Same Coin?
2022,
Pubmed
Shoup,
Substitution-inert polynuclear platinum compounds inhibit human cytomegalovirus attachment and entry.
2020,
Pubmed
Skowronski,
Severe acute respiratory syndrome (SARS): a year in review.
2005,
Pubmed
Tandon,
Effective Inhibition of SARS-CoV-2 Entry by Heparin and Enoxaparin Derivatives.
2021,
Pubmed
Vasconcelos,
Anticoagulant and Antithrombotic Properties of Three Structurally Correlated Sea Urchin Sulfated Glycans and Their Low-Molecular-Weight Derivatives.
2018,
Pubmed
,
Echinobase
Wang,
The effects of the COVID-19 pandemic on the mental health of workers and the associated social-economic aspects: A narrative review.
2023,
Pubmed
Wang,
Inhibition of Influenza A Virus Infection by Fucoidan Targeting Viral Neuraminidase and Cellular EGFR Pathway.
2017,
Pubmed
Warkentin,
Heparin-induced thrombocytopenia.
1989,
Pubmed
Yim,
Antiviral effects of sulfated exopolysaccharide from the marine microalga Gyrodinium impudicum strain KG03.
2004,
Pubmed
Zhong,
Epidemiology and cause of severe acute respiratory syndrome (SARS) in Guangdong, People's Republic of China, in February, 2003.
2003,
Pubmed
Zoepfl,
Antiviral activities of four marine sulfated glycans against adenovirus and human cytomegalovirus.
2021,
Pubmed
,
Echinobase
de Paiva,
What is holding back the development of antiviral metallodrugs? A literature overview and implications for SARS-CoV-2 therapeutics and future viral outbreaks.
2020,
Pubmed