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Prospecting Local Treatments Used in Conjunction with Antivenom Administration Following Envenomation Caused by Animals: A Systematic Review.
Carvalho ÉS
,
Oliveira I
,
Nascimento TP
,
da Silva Neto AV
,
Leal BAS
,
Araújo FQ
,
Julião BFV
,
Souza ARN
,
Abrahim AW
,
Macedo BBO
,
de Oliveira JTS
,
Wen FH
,
Pucca MB
,
Monteiro WM
,
Sachett JAG
.
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Envenomation caused by venomous animals may trigger significant local complications such as pain, edema, localized hemorrhage, and tissue necrosis, in addition to complications such as dermonecrosis, myonecrosis, and even amputations. This systematic review aims to evaluate scientific evidence on therapies used to target local effects caused by envenomation. The PubMed, MEDLINE, and LILACS databases were used to perform a literature search on the topic. The review was based on studies that cited procedures performed on local injuries following envenomation with the aim of being an adjuvant therapeutic strategy. The literature regarding local treatments used following envenomation reports the use of several alternative methods and/or therapies. The venomous animals found in the search were snakes (82.05%), insects (2.56%), spiders (2.56%), scorpions (2.56%), and others (jellyfish, centipede, sea urchin-10.26%). In regard to the treatments, the use of tourniquets, corticosteroids, antihistamines, and cryotherapy is questionable, as well as the use of plants and oils. Low-intensity lasers stand out as a possible therapeutic tool for these injuries. Local complications can progress to serious conditions and may result in physical disabilities and sequelae. This study compiled information on adjuvant therapeutic measures and underscores the importance of more robust scientific evidence for recommendations that act on local effects together with the antivenom.
Aguayo-Albasini,
[GRADE system: classification of quality of evidence and strength of recommendation].
2014, Pubmed
Aguayo-Albasini,
[GRADE system: classification of quality of evidence and strength of recommendation].
2014,
Pubmed
Aksel,
A randomized trial comparing intravenous paracetamol, topical lidocaine, and ice application for treatment of pain associated with scorpion stings.
2015,
Pubmed
Amaral,
Tourniquet ineffectiveness to reduce the severity of envenoming after Crotalus durissus snake bite in Belo Horizonte, Minas Gerais, Brazil.
1998,
Pubmed
Aranha de Sousa,
Effects of a low-level semiconductor gallium arsenide laser on local pathological alterations induced by Bothrops moojeni snake venom.
2013,
Pubmed
Bar-On,
On the form and bio-mechanics of venom-injection elements.
2019,
Pubmed
Barbosa,
Effect of low-level laser therapy in the inflammatory response induced by Bothrops jararacussu snake venom.
2008,
Pubmed
Barbosa,
Effect of low-level laser therapy in the myonecrosis induced by Bothrops jararacussu snake venom.
2009,
Pubmed
Binder,
Acute arthropod envenomation. Incidence, clinical features and management.
1989,
Pubmed
Burgess,
Effects of constriction bands on rattlesnake venom absorption: a pharmacokinetic study.
1992,
Pubmed
Carlson,
Large local reactions to insect envenomation.
2016,
Pubmed
Chaou,
Comparisons of ice packs, hot water immersion, and analgesia injection for the treatment of centipede envenomations in Taiwan.
2009,
Pubmed
Chippaux,
Study of the efficacy of the black stone on envenomation by snake bite in the murine model.
2007,
Pubmed
De Oliveira,
Inhibitory effect of plant Manilkara subsericea against biological activities of Lachesis muta snake venom.
2014,
Pubmed
Doin-Silva,
The ability of low level laser therapy to prevent muscle tissue damage induced by snake venom.
2009,
Pubmed
Dourado,
Effects of the Ga-As laser irradiation on myonecrosis caused by Bothrops Moojeni snake venom.
2003,
Pubmed
Dourado,
Effects of photobiomodulation therapy on Bothrops moojeni snake-envenomed gastrocnemius of mice using enzymatic biomarkers.
2017,
Pubmed
Dourado,
Low-level laser therapy promotes vascular endothelial growth factor receptor-1 expression in endothelial and nonendothelial cells of mice gastrocnemius exposed to snake venom.
2011,
Pubmed
Elwakil,
An in-vivo experimental evaluation of He-Ne laser photostimulation in healing Achilles tendons.
2007,
Pubmed
Exton,
Cold packs: effective topical analgesia in the treatment of painful stings by Physalia and other jellyfish.
NULL,
Pubmed
Feitosa,
Older Age and Time to Medical Assistance Are Associated with Severity and Mortality of Snakebites in the Brazilian Amazon: A Case-Control Study.
2015,
Pubmed
Fitzgerald,
Hymenoptera stings.
2006,
Pubmed
Frozanfar,
The Effects of Low Level Laser Therapy on the Expression of Collagen Type I Gene and Proliferation of Human Gingival Fibroblasts (Hgf3-Pi 53): in vitro Study.
2013,
Pubmed
Félix-Silva,
Medicinal Plants for the Treatment of Local Tissue Damage Induced by Snake Venoms: An Overview from Traditional Use to Pharmacological Evidence.
2017,
Pubmed
Golden,
Venom immunotherapy reduces large local reactions to insect stings.
2009,
Pubmed
Gomes,
Aqueous Leaf Extract of Jatropha mollissima (Pohl) Bail Decreases Local Effects Induced by Bothropic Venom.
2016,
Pubmed
Gouveia,
Photobiomodulation reduces cell death and cytokine production in C2C12 cells exposed to Bothrops venoms.
2020,
Pubmed
Gutiérrez,
Trends in snakebite envenomation therapy: scientific, technological and public health considerations.
2007,
Pubmed
Hibel,
Prevention and primary care treatment of stings from imported fire ants.
1992,
Pubmed
Howe,
Electric shock does not save snakebitten rats.
1988,
Pubmed
Jorge,
Failure of chloramphenicol prophylaxis to reduce the frequency of abscess formation as a complication of envenoming by Bothrops snakes in Brazil: a double-blind randomized controlled trial.
2004,
Pubmed
Korambayil,
A Multidisciplinary Approach with Hyperbaric Oxygen Therapy Improve Outcome in Snake Bite Injuries.
2015,
Pubmed
Leach,
Brown recluse spider bites to the head: three cases and a review.
2004,
Pubmed
Lomonte,
Neutralizing interaction between heparins and myotoxin II, a lysine 49 phospholipase A2 from Bothrops asper snake venom. Identification of a heparin-binding and cytolytic toxin region by the use of synthetic peptides and molecular modeling.
1994,
Pubmed
Maciel Salazar,
Snakebites in "Invisible Populations": A cross-sectional survey in riverine populations in the remote western Brazilian Amazon.
2021,
Pubmed
Mendes,
Secondary infection profile after snakebite treated at a tertiary referral center in the Brazilian Amazon.
2022,
Pubmed
Nadur-Andrade,
Analgesic Effect of Light-Emitting Diode (LED) Therapy at Wavelengths of 635 and 945 nm on Bothrops moojeni Venom-Induced Hyperalgesia.
2014,
Pubmed
Nadur-Andrade,
Effects of photobiostimulation on edema and hemorrhage induced by Bothrops moojeni venom.
2012,
Pubmed
Nadur-Andrade,
Analgesic Effect of Photobiomodulation on Bothrops Moojeni Venom-Induced Hyperalgesia: A Mechanism Dependent on Neuronal Inhibition, Cytokines and Kinin Receptors Modulation.
2016,
Pubmed
Nadur-Andrade,
Photobiostimulation reduces edema formation induced in mice by Lys-49 phospholipases A2 isolated from Bothrops moojeni venom.
2014,
Pubmed
Nelson,
Snake envenomation. Incidence, clinical presentation and management.
1989,
Pubmed
Nomura,
A randomized paired comparison trial of cutaneous treatments for acute jellyfish (Carybdea alata) stings.
2002,
Pubmed
Phillips,
Therapy of brown spider envenomation: a controlled trial of hyperbaric oxygen, dapsone, and cyproheptadine.
1995,
Pubmed
Premmaneesakul,
Toxic jellyfish in Thailand.
2019,
Pubmed
Résière,
Oral Microbiota of the Snake Bothrops lanceolatus in Martinique.
2018,
Pubmed
Sachett,
Bothrops atrox Snakebite: How a Bad Decision May Lead to a Chronic Disability: A Case Report.
2020,
Pubmed
Sachett,
Poor efficacy of preemptive amoxicillin clavulanate for preventing secondary infection from Bothrops snakebites in the Brazilian Amazon: A randomized controlled clinical trial.
2017,
Pubmed
Salama,
Rosemary leaves extract: Anti-snake action against Egyptian Cerastes cerastes venom.
2018,
Pubmed
Santos Barreto,
Experimental Bothrops atrox envenomation: Efficacy of antivenom therapy and the combination of Bothrops antivenom with dexamethasone.
2017,
Pubmed
Saturnino-Oliveira,
Abarema cochliacarpos extract decreases the inflammatory process and skeletal muscle injury induced by Bothrops leucurus venom.
2014,
Pubmed
Shaikh,
Assessment of Cultivable Oral Bacterial Flora from Important Venomous Snakes of India and Their Antibiotic Susceptibilities.
2017,
Pubmed
Shedoeva,
Wound Healing and the Use of Medicinal Plants.
2019,
Pubmed
Silva,
Photobiomodulation therapy on bothrops snake venom-induced local pathological effects: A systematic review.
2018,
Pubmed
Silva,
Photobiomodulation Protects and Promotes Differentiation of C2C12 Myoblast Cells Exposed to Snake Venom.
2016,
Pubmed
Singh,
A Review on Venom Enzymes Neutralizing Ability of Secondary Metabolites from Medicinal Plants.
2017,
Pubmed
Sivaraman,
Antitoxin activity of aqueous extract of Cyclea peltata root against Naja naja venom.
2017,
Pubmed
Smith,
Laser (and LED) therapy is phototherapy.
2005,
Pubmed
Souza,
Effect of low-level laser therapy on the modulation of the mitochondrial activity of macrophages.
2014,
Pubmed
Sutherland,
Rationalisation of first-aid measures for elapid snakebite.
1979,
Pubmed
Tan,
Scorpion stings presenting to an emergency department in Singapore with special reference to Isometrus maculatus.
2013,
Pubmed
Tavares,
Epidemiology of the injury with venomous animals in the state of Rio Grande do Norte, Northeast of Brazil.
2020,
Pubmed
Tribuiani,
Vellozia flavicans Mart. ex Schult. hydroalcoholic extract inhibits the neuromuscular blockade induced by Bothrops jararacussu venom.
2014,
Pubmed
Tun-Pe,
The efficacy of tourniquets as a first-aid measure for Russell's viper bites in Burma.
1987,
Pubmed
Varl,
Yellow sac spider (Cheiracanthium punctorium) bites in Slovenia: case series and review.
2017,
Pubmed
Vieira,
Low-Level Laser Therapy (904 nm) Counteracts Motor Deficit of Mice Hind Limb following Skeletal Muscle Injury Caused by Snakebite-Mimicking Intramuscular Venom Injection.
2016,
Pubmed
Villas-Boas,
Venomous caterpillars: From inoculation apparatus to venom composition and envenomation.
2018,
Pubmed
Wasserman,
Wound care of spider and snake envenomations.
1988,
Pubmed
Weinstein,
Local envenoming by the Western hognose snake (Heterodon nasicus): a case report and review of medically significant Heterodon bites.
2009,
Pubmed
Zeng,
Small Incisions Combined with Negative-Pressure Wound Therapy for Treatment of Protobothrops Mucrosquamatus Bite Envenomation: A New Treatment Strategy.
2019,
Pubmed
