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Mar Drugs
2022 Oct 21;2010:. doi: 10.3390/md20100653.
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Branched Chondroitin Sulfate Oligosaccharides Derived from the Sea Cucumber Acaudina molpadioides Stimulate Neurite Outgrowth.
Wang W
,
Mao H
,
Li S
,
Zhang L
,
Yang L
,
Yin R
,
Zhao J
.
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Fucosylated chondroitin sulfate (FCS) from the sea cucumber Acaudina molpadioides (FCSAm) is the first one that was reported to be branched by disaccharide GalNAc-(α1,2)-Fuc3S4S (15%) and sulfated Fuc (85%). Here, four size-homogenous fractions, and seven oligosaccharides, were separated from its β-eliminative depolymerized products. Detailed NMR spectroscopic and MS analyses revealed the oligomers as hexa-, hepta-, octa-, and nonasaccharide, which further confirmed the precise structure of native FCSAm: it was composed of the CS-E-like backbone with a full content of sulfation at O-4 and O-6 of GalNAc in the disaccharide repeating unit, and the branches consisting of sulfated fucose (Fuc4S and Fuc2S4S) and heterodisaccharide [GalNAc-(α1,2)-Fuc3S4S]. Pharmacologically, FCSAm and its depolymerized derivatives, including fractions and oligosaccharides, showed potent neurite outgrowth-promoting activity in a chain length-dependent manner. A comparison of analyses among oligosaccharides revealed that the sulfate pattern of the Fuc branches, instead of the heterodisaccharide, could affect the promotion intensity. Fuc2S4S and the saccharide length endowed the neurite outgrowth stimulation activity most.
Brewer,
Optimized survival of hippocampal neurons in B27-supplemented Neurobasal, a new serum-free medium combination.
1993, Pubmed
Brewer,
Optimized survival of hippocampal neurons in B27-supplemented Neurobasal, a new serum-free medium combination.
1993,
Pubmed
Brewer,
Isolation and culture of adult neurons and neurospheres.
2007,
Pubmed
Clement,
Chondroitin sulfate E promotes neurite outgrowth of rat embryonic day 18 hippocampal neurons.
1999,
Pubmed
Dow,
Neuronal proteoglycans: biosynthesis and functional interaction with neurons in vitro.
1988,
Pubmed
Gama,
Sulfation patterns of glycosaminoglycans encode molecular recognition and activity.
2006,
Pubmed
Gilbert,
CS-4,6 is differentially upregulated in glial scar and is a potent inhibitor of neurite extension.
2005,
Pubmed
Higashi,
Identification of keratan sulfate disaccharide at C-3 position of glucuronate of chondroitin sulfate from Mactra chinensis.
2016,
Pubmed
Hikino,
Oversulfated dermatan sulfate exhibits neurite outgrowth-promoting activity toward embryonic mouse hippocampal neurons: implications of dermatan sulfate in neuritogenesis in the brain.
2003,
Pubmed
,
Echinobase
Huang,
The depolymerized fucosylated chondroitin sulfate from sea cucumber potently inhibits HIV replication via interfering with virus entry.
2013,
Pubmed
,
Echinobase
Kim,
Comparative Analysis of the Expression of Chondroitin Sulfate Subtypes and Their Inhibitory Effect on Axonal Growth in the Embryonic, Adult, and Injured Rat Brains.
2021,
Pubmed
Li,
Structural Elucidation and Biological Activity of a Highly Regular Fucosylated Glycosaminoglycan from the Edible Sea Cucumber Stichopus herrmanni.
2017,
Pubmed
,
Echinobase
Li,
Low-molecular-weight fucosylated glycosaminoglycan and its oligosaccharides from sea cucumber as novel anticoagulants: A review.
2021,
Pubmed
,
Echinobase
Li,
Structural characterization and anticoagulant analysis of the novel branched fucosylated glycosaminoglycan from sea cucumber Holothuria nobilis.
2021,
Pubmed
,
Echinobase
Maeda,
6B4 proteoglycan/phosphacan is a repulsive substratum but promotes morphological differentiation of cortical neurons.
1996,
Pubmed
Mao,
A new fucosylated glycosaminoglycan containing disaccharide branches from Acaudina molpadioides: Unusual structure and anti-intrinsic tenase activity.
2020,
Pubmed
,
Echinobase
Pomin,
Galactosaminoglycans: Medical Applications and Drawbacks.
2019,
Pubmed
,
Echinobase
Shida,
A characteristic chondroitin sulfate trisaccharide unit with a sulfated fucose branch exhibits neurite outgrowth-promoting activity: Novel biological roles of fucosylated chondroitin sulfates isolated from the sea cucumber Apostichopus japonicus.
2017,
Pubmed
,
Echinobase
Snow,
Neurite outgrowth on a step gradient of chondroitin sulfate proteoglycan (CS-PG).
1992,
Pubmed
Sotogaku,
Activation of phospholipase C pathways by a synthetic chondroitin sulfate-E tetrasaccharide promotes neurite outgrowth of dopaminergic neurons.
2007,
Pubmed
Sugahara,
Recent advances in the structural biology of chondroitin sulfate and dermatan sulfate.
2003,
Pubmed
Tully,
A chondroitin sulfate small molecule that stimulates neuronal growth.
2004,
Pubmed
Xu,
Holothurian fucosylated chondroitin sulfates and their potential benefits for human health: Structures and biological activities.
2022,
Pubmed
,
Echinobase
Yang,
Long-term primary culture of highly-pure rat embryonic hippocampal neurons of low-density.
2010,
Pubmed
Yin,
Re-understanding of structure and anticoagulation: Fucosylated chondroitin sulfate from sea cucumber Ludwigothurea grisea.
2022,
Pubmed
,
Echinobase
Yin,
Unveiling the Disaccharide-Branched Glycosaminoglycan and Anticoagulant Potential of Its Derivatives.
2021,
Pubmed
,
Echinobase
Yin,
Oligosaccharides from depolymerized fucosylated glycosaminoglycan: Structures and minimum size for intrinsic factor Xase complex inhibition.
2018,
Pubmed
,
Echinobase
Zhao,
Discovery of an intrinsic tenase complex inhibitor: Pure nonasaccharide from fucosylated glycosaminoglycan.
2015,
Pubmed
Zuo,
Degradation of chondroitin sulfate proteoglycan enhances the neurite-promoting potential of spinal cord tissue.
1998,
Pubmed
