Click
here to close Hello! We notice that
you are using Internet Explorer, which is not supported by Echinobase
and may cause the site to display incorrectly. We suggest using a
current version of Chrome,
FireFox,
or Safari.
Mar Drugs
2022 Dec 28;211:. doi: 10.3390/md21010025.
Show Gene links
Show Anatomy links
Therapeutic Potency of Ovothiol A on Ethanol-Induced Gastric Ulcers in Wistar Rats.
Salaheldin AT
,
Shehata MR
,
Sakr HI
,
Atia T
,
Mohamed AS
.
???displayArticle.abstract???
Peptic ulcer is a widespread disease, with a lifetime frequency of 5−10% among the general population and an annual incidence of 0.1−0.3%. Ovothiol A is naturally produced from sea urchin eggs with special antioxidant activity. Gastric ulcers were induced in rats by a single ethanol dose (5 mL/kg). The rats were divided into control, ulcer, and ulcer with 250 and 500 mg/kg ovothiol A doses. Molecular docking studies were used to examine the interactions between ovothiol A and the H+/K+ ATPase active site residues. Ovothiol A led to a significant decline (p < 0.05) in gastric juice volume, ulcer index, MDA, IL-6, and cytochrome c, while levels of gastric juice pH, GSH, CAT, GST, SOD, and NO increased. Histopathological investigation of stomach sections revealed architecture preservation of the gastric mucosa after ovothiol A administration. The anti-ulcerogenic activity of ovothiol A includes scavenging free radicals, inhibition of inflammation, regulation of apoptosis, and stabilization of fibroblast growth factors to promote gastric ulcers healing.
Alvarez-Suarez,
Strawberry polyphenols attenuate ethanol-induced gastric lesions in rats by activation of antioxidant enzymes and attenuation of MDA increase.
2011, Pubmed
Alvarez-Suarez,
Strawberry polyphenols attenuate ethanol-induced gastric lesions in rats by activation of antioxidant enzymes and attenuation of MDA increase.
2011,
Pubmed
Arab,
Diosmin protects against ethanol-induced gastric injury in rats: novel anti-ulcer actions.
2015,
Pubmed
Blunt,
Marine natural products.
2018,
Pubmed
Brancaccio,
Antifibrotic Effect of Marine Ovothiol in an In Vivo Model of Liver Fibrosis.
2018,
Pubmed
,
Echinobase
Brynskov,
Cytokines in inflammatory bowel disease.
1992,
Pubmed
Castellano,
Anti-Inflammatory Activity of Marine Ovothiol A in an In Vitro Model of Endothelial Dysfunction Induced by Hyperglycemia.
2018,
Pubmed
,
Echinobase
El Badawy,
Benzyl isothiocyanates modulate inflammation, oxidative stress, and apoptosis via Nrf2/HO-1 and NF-κB signaling pathways on indomethacin-induced gastric injury in rats.
2021,
Pubmed
El-Abhar,
Coenzyme Q10: a novel gastroprotective effect via modulation of vascular permeability, prostaglandin E₂, nitric oxide and redox status in indomethacin-induced gastric ulcer model.
2010,
Pubmed
El-Maraghy,
Gastroprotective effect of crocin in ethanol-induced gastric injury in rats.
2015,
Pubmed
Huang,
Cytoprotective effect of American ginseng in a rat ethanol gastric ulcer model.
2013,
Pubmed
Ianora,
The relevance of marine chemical ecology to plankton and ecosystem function: an emerging field.
2011,
Pubmed
Jacob,
A scent of therapy: pharmacological implications of natural products containing redox-active sulfur atoms.
2006,
Pubmed
Konturek,
Inhibition of nitric oxide synthase delays healing of chronic gastric ulcers.
1993,
Pubmed
Kuna,
Peptic Ulcer Disease: A Brief Review of Conventional Therapy and Herbal Treatment Options.
2019,
Pubmed
Laine,
Histology of alcoholic hemorrhagic "gastritis": a prospective evaluation.
1988,
Pubmed
Lanas,
Peptic ulcer disease.
2017,
Pubmed
Lanas,
The changing face of hospitalisation due to gastrointestinal bleeding and perforation.
2011,
Pubmed
Leow,
Time trends in upper gastrointestinal diseases and Helicobacter pylori infection in a multiracial Asian population--a 20-year experience over three time periods.
2016,
Pubmed
Liang,
The role of nitric oxide in peptic ulcer: a narrative review.
2021,
Pubmed
Liu,
Protective effect of l-citrulline against ethanol-induced gastric ulcer in rats.
2012,
Pubmed
Lv,
Sulforaphane prevents chromium-induced lung injury in rats via activation of the Akt/GSK-3β/Fyn pathway.
2020,
Pubmed
Maity,
Indomethacin, a non-steroidal anti-inflammatory drug, develops gastropathy by inducing reactive oxygen species-mediated mitochondrial pathology and associated apoptosis in gastric mucosa: a novel role of mitochondrial aconitase oxidation.
2009,
Pubmed
Maity,
Melatonin reduces indomethacin-induced gastric mucosal cell apoptosis by preventing mitochondrial oxidative stress and the activation of mitochondrial pathway of apoptosis.
2009,
Pubmed
Malmi,
Incidence and complications of peptic ulcer disease requiring hospitalisation have markedly decreased in Finland.
2014,
Pubmed
Moawad,
Gastroprotective effect of cilostazol against ethanol- and pylorus ligation-induced gastric lesions in rats.
2019,
Pubmed
Mohamed,
Sodium pentobarbital dosages for exsanguination affect biochemical, molecular and histological measurements in rats.
2020,
Pubmed
Russo,
Ovothiol isolated from sea urchin oocytes induces autophagy in the Hep-G2 cell line.
2014,
Pubmed
,
Echinobase
Salga,
Gastroprotective activity and mechanism of novel dichlorido-zinc(II)-4-(2-(5-methoxybenzylideneamino)ethyl)piperazin-1-iumphenolate complex on ethanol-induced gastric ulceration.
2012,
Pubmed
Sawadogo,
A survey of marine natural compounds and their derivatives with anti-cancer activity reported in 2011.
2013,
Pubmed
Schmidt,
Galium verum aqueous extract strongly inhibits the motility of head and neck cancer cell lines and protects mucosal keratinocytes against toxic DNA damage.
2014,
Pubmed
Shapiro,
Oxidative stress and the role of novel thiol compounds at fertilization.
1988,
Pubmed
Sistani Karampour,
Gastroprotective Effect of Zingerone on Ethanol-Induced Gastric Ulcers in Rats.
2019,
Pubmed
Sonnenberg,
Time trends of ulcer mortality in Europe.
2007,
Pubmed
Sonnenberg,
Time trends of ulcer mortality in non-European countries.
2007,
Pubmed
Sumbul,
Role of phenolic compounds in peptic ulcer: An overview.
2011,
Pubmed
Sun,
Gastroprotective effect and mechanisms of Chinese sumac fruits (Rhus chinensis Mill.) on ethanol-induced gastric ulcers in mice.
2021,
Pubmed
Suo,
Lactobacillus fermentum Suo Attenuates HCl/Ethanol Induced Gastric Injury in Mice through Its Antioxidant Effects.
2016,
Pubmed
Sánchez-Mendoza,
Gastroprotection of Calein D against Ethanol-Induced Gastric Lesions in Mice: Role of Prostaglandins, Nitric Oxide and Sulfhydryls.
2019,
Pubmed
Tsutsumi,
Gastric irritant-induced apoptosis in guinea pig gastric mucosal cells in primary culture.
2002,
Pubmed
Wang,
Gastroprotective activity of polysaccharide from Hericium erinaceus against ethanol-induced gastric mucosal lesion and pylorus ligation-induced gastric ulcer, and its antioxidant activities.
2018,
Pubmed
Wu,
Lactobacillus plantarum ZS62 Alleviates Alcohol-Induced Gastric Injury in Mice via an Anti-Oxidative Mechanism.
2021,
Pubmed
Xie,
The global, regional and national burden of peptic ulcer disease from 1990 to 2019: a population-based study.
2022,
Pubmed
Xie,
Gastroprotective effect of gamma-aminobutyric acid against ethanol-induced gastric mucosal injury.
2017,
Pubmed
Xue,
Protective effect of polysaccharides from Radix Hedysari on gastric ulcers induced by acetic acid in rats.
2019,
Pubmed
Zhang,
Protective effects of polysaccharide from Dendrobium nobile against ethanol-induced gastric damage in rats.
2018,
Pubmed
Zhao,
Protective effects of DIDS against ethanol-induced gastric mucosal injury in rats.
2009,
Pubmed
Zhu,
Structural studies of the binding of the anti-ulcer drug sucrose octasulfate to acidic fibroblast growth factor.
1993,
Pubmed
de Araújo,
Gastroprotective and Antioxidant Activity of Kalanchoe brasiliensis and Kalanchoe pinnata Leaf Juices against Indomethacin and Ethanol-Induced Gastric Lesions in Rats.
2018,
Pubmed
