Click
here to close Hello! We notice that
you are using Internet Explorer, which is not supported by Echinobase
and may cause the site to display incorrectly. We suggest using a
current version of Chrome,
FireFox,
or Safari.
Effects of Sulfamethoxazole on Fertilization and Embryo Development in the Arbacia lixula Sea Urchin.
Lazzara V
,
Mauro M
,
Celi M
,
Cammilleri G
,
Vizzini A
,
Luparello C
,
Bellini P
,
Ferrantelli V
,
Vazzana M
.
???displayArticle.abstract???
To date, drugs released into the aquatic environment are a real problem, and among antibiotics, sulfamethoxazole is the one most widely found in wastewater; thus, the evaluation of its toxicity on marine organisms is very important. This study, for the first time, investigates the in vitro effects of 4 concentrations of sulfamethoxazole (0.05 mg/L, 0.5 mg/L, 5 mg/L, 50 mg/L) on the fertilization and development of the sea urchin Arbacia lixula. The gametes were exposed to drugs in three different stages: simultaneously with, prior to, and post-fertilization. The results show a significant reduction in the percentage of fertilized oocytes at the highest drug concentrations. Moreover, an increase in anomalies and delays in embryo development following the treatment with the drug was demonstrated. Therefore, the data suggest that this antibiotic can alter the development of marine organisms, making it urgent to act to reduce their release and to determine the concentration range with the greatest impact.
Figure 1. Percentage of unfertilized eggs (A) and regular divisions (B) considering division stages with a number of blastomeres ⥠16 after the simultaneous exposure (SE) of the eggs and spermatozoa to the SMX solutions. Black bars represent medians.
Figure 2. Percentage of unfertilized eggs (A) and embryosâ regular divisions (B) considering division stages with a number of blastomeres ⥠16 after preventive exposure (PE) of the gametes to the sulfamethoxazole solutions. Black bars represent medians.
Figure 3. Percentage of embryosâ regular (A), irregular (B), and delayed divisions (C) at 2 h post-fertilization after incubation with sulfamethoxazole solutions (SMX) considering division stages with a number of blastomeres ⥠16.
Almeida,
Long-term effects of oxytetracycline exposure in zebrafish: A multi-level perspective.
2019, Pubmed
Almeida,
Long-term effects of oxytetracycline exposure in zebrafish: A multi-level perspective.
2019,
Pubmed
Apaydın,
Sulfonamide derivatives as multi-target agents for complex diseases.
2019,
Pubmed
Assress,
Occurrence and risk assessment of azole antifungal drugs in water and wastewater.
2020,
Pubmed
Aulsebrook,
Reproduction in a polluted world: implications for wildlife.
2020,
Pubmed
Aydin,
Antibiotics in hospital effluents: occurrence, contribution to urban wastewater, removal in a wastewater treatment plant, and environmental risk assessment.
2019,
Pubmed
Blair,
Evaluating the degradation, sorption, and negative mass balances of pharmaceuticals and personal care products during wastewater treatment.
2015,
Pubmed
Bonnefille,
Metabolomics assessment of the effects of diclofenac exposure on Mytilus galloprovincialis: Potential effects on osmoregulation and reproduction.
2018,
Pubmed
Böttger,
The effects of organic and inorganic phosphates on fertilization and early development in the sea urchin Lytechinus variegatus (Echinodermata: Echinoidea).
2001,
Pubmed
,
Echinobase
Branchet,
Pharmaceuticals in the marine environment: What are the present challenges in their monitoring?
2021,
Pubmed
Cakal Arslan,
Embryotoxic effects of nonylphenol and octylphenol in sea urchin Arbacia lixula.
2007,
Pubmed
,
Echinobase
Carvalho,
Antibiotics in the aquatic environments: A review of the European scenario.
2016,
Pubmed
de Oliveira,
Acute and chronic ecotoxicological effects of four pharmaceuticals drugs on cladoceran Daphnia magna.
2016,
Pubmed
Di Paola,
Environmental Risk Assessment of Oxaliplatin Exposure on Early Life Stages of Zebrafish (Danio rerio).
2022,
Pubmed
Di Paola,
Aflatoxin B1 Toxicity in Zebrafish Larva (Danio rerio): Protective Role of Hericium erinaceus.
2021,
Pubmed
Drzymała,
Ecotoxic interactions between pharmaceuticals in mixtures: Diclofenac and sulfamethoxazole.
2020,
Pubmed
Duan,
Occurrence and ecotoxicity of sulfonamides in the aquatic environment: A review.
2022,
Pubmed
Ekpeghere,
Occurrence and distribution of carbamazepine, nicotine, estrogenic compounds, and their transformation products in wastewater from various treatment plants and the aquatic environment.
2018,
Pubmed
Fabbri,
Human pharmaceuticals in the marine environment: Focus on exposure and biological effects in animal species.
2016,
Pubmed
Faleye,
Identification of antibiotics in wastewater: current state of extraction protocol and future perspectives.
2017,
Pubmed
Giménez,
Effects of commonly used therapeutic drugs, paracetamol, and acetylsalicylic acid, on key physiological traits of the sea snail Gibbula umbilicalis.
2019,
Pubmed
Gracia-Lor,
Occurrence and removal of pharmaceuticals in wastewater treatment plants at the Spanish Mediterranean area of Valencia.
2012,
Pubmed
Heberer,
Occurrence, fate, and removal of pharmaceutical residues in the aquatic environment: a review of recent research data.
2002,
Pubmed
Inguglia,
Salmo salar fish waste oil: Fatty acids composition and antibacterial activity.
2020,
Pubmed
Lazzara,
Bright Spots in The Darkness of Cancer: A Review of Starfishes-Derived Compounds and Their Anti-Tumor Action.
2019,
Pubmed
,
Echinobase
Le-Minh,
Fate of antibiotics during municipal water recycling treatment processes.
2010,
Pubmed
Lewis,
Reproductive consequences of paternal genotoxin exposure in marine invertebrates.
2009,
Pubmed
Lewis,
Infertility in male aquatic invertebrates: a review.
2012,
Pubmed
Limbu,
Chronic exposure to low environmental concentrations and legal aquaculture doses of antibiotics cause systemic adverse effects in Nile tilapia and provoke differential human health risk.
2018,
Pubmed
Liu,
Early exposure to environmental levels of sulfamethoxazole triggers immune and inflammatory response of healthy zebrafish larvae.
2020,
Pubmed
Liu,
Toxic effects of diclofenac on life history parameters and the expression of detoxification-related genes in Daphnia magna.
2017,
Pubmed
Luparello,
Collective Locomotion of Human Cells, Wound Healing and Their Control by Extracts and Isolated Compounds from Marine Invertebrates.
2020,
Pubmed
Luparello,
Histone Deacetylase Inhibitors from Marine Invertebrates.
2020,
Pubmed
,
Echinobase
Madikizela,
Status of pharmaceuticals in African water bodies: Occurrence, removal and analytical methods.
2017,
Pubmed
Marin,
Embryotoxicity of butyltin compounds to the sea urchin Paracentrotus lividus.
2000,
Pubmed
,
Echinobase
Marques,
Marine organism sulfated polysaccharides exhibiting significant antimalarial activity and inhibition of red blood cell invasion by Plasmodium.
2016,
Pubmed
,
Echinobase
Mauro,
Human Drug Pollution in the Aquatic System: The Biochemical Responses of Danio rerio Adults.
2021,
Pubmed
Mauro,
Antitumoral compounds from vertebrate sister group: A review of Mediterranean ascidians.
2020,
Pubmed
Mauro,
Humoral responses during wound healing in Holothuria tubulosa (Gmelin, 1788).
2021,
Pubmed
,
Echinobase
Mauro,
The effect of low frequency noise on the behaviour of juvenile Sparus aurata.
2020,
Pubmed
Mearns,
Effects of Pollution on Marine Organisms.
2015,
Pubmed
Medina,
The effect of diamino diphenyl sulfone on the embryonic development of eggs from the sea urchin (Lytechinus variegatus).
1986,
Pubmed
,
Echinobase
Mello,
Ecotoxicological assessment of chemotherapeutic agents using toxicity tests with embryos of Mellita quinquiesperforata.
2020,
Pubmed
,
Echinobase
Mezzelani,
Ecotoxicological potential of non-steroidal anti-inflammatory drugs (NSAIDs) in marine organisms: Bioavailability, biomarkers and natural occurrence in Mytilus galloprovincialis.
2016,
Pubmed
Morroni,
Sea cucumber Holothuria polii (Delle Chiaje, 1823) as new model for embryo bioassays in ecotoxicological studies.
2020,
Pubmed
,
Echinobase
Nunes,
Acute effects of tetracycline exposure in the freshwater fish Gambusia holbrooki: antioxidant effects, neurotoxicity and histological alterations.
2015,
Pubmed
Parisi,
Temperature increases, hypoxia, and changes in food availability affect immunological biomarkers in the marine mussel Mytilus galloprovincialis.
2017,
Pubmed
Pesando,
Effects of methoxychlor, dieldrin and lindane on sea urchin fertilization and early development.
2004,
Pubmed
,
Echinobase
Pinto,
Ecotoxicological effects of lanthanum in Mytilus galloprovincialis: Biochemical and histopathological impacts.
2019,
Pubmed
Punginelli,
The potential of antimicrobial peptides isolated from freshwater crayfish species in new drug development: A review.
2022,
Pubmed
Ragusa,
Coexposure to sulfamethoxazole and cadmium impairs development and attenuates transcriptional response in sea urchin embryo.
2017,
Pubmed
,
Echinobase
Ribeiro,
Toxicity screening of diclofenac, propranolol, sertraline and simvastatin using Danio rerio and Paracentrotus lividus embryo bioassays.
2015,
Pubmed
,
Echinobase
Rodriguez-Mozaz,
Antibiotic residues in final effluents of European wastewater treatment plants and their impact on the aquatic environment.
2020,
Pubmed
Serra-Compte,
Comprehensive study of sulfamethoxazole effects in marine mussels: Bioconcentration, enzymatic activities and metabolomics.
2019,
Pubmed
Sukul,
Sulfonamides in the environment as veterinary drugs.
2006,
Pubmed
Świacka,
Mytilidae as model organisms in the marine ecotoxicology of pharmaceuticals - A review.
2019,
Pubmed
Thiebault,
Sulfamethoxazole/Trimethoprim ratio as a new marker in raw wastewaters: A critical review.
2020,
Pubmed
Van Kesteren,
E7070: a novel synthetic sulfonamide targeting the cell cycle progression for the treatment of cancer.
2002,
Pubmed
Vazzana,
Effects of acoustic stimulation on biochemical parameters in the digestive gland of Mediterranean mussel Mytilus galloprovincialis (Lamarck, 1819).
2020,
Pubmed
Vazzana,
Underwater high frequency noise: Biological responses in sea urchin Arbacia lixula (Linnaeus, 1758).
2020,
Pubmed
,
Echinobase
Vizzini,
Transcriptomic Analyses Reveal 2 and 4 Family Members of Cytochromes P450 (CYP) Involved in LPS Inflammatory Response in Pharynx of Ciona robusta.
2021,
Pubmed
Volpi Ghirardini,
Sediment toxicity assessment in the Lagoon of Venice (Italy) using Paracentrotus lividus (Echinodermata: Echinoidea) fertilization and embryo bioassays.
2005,
Pubmed
,
Echinobase
Wishart,
DrugBank 5.0: a major update to the DrugBank database for 2018.
2018,
Pubmed
Yang,
Biomarker Effects in Carassius auratus Exposure to Ofloxacin, Sulfamethoxazole and Ibuprofen.
2019,
Pubmed
Yi,
CCL113, a novel sulfonamide, induces selective mitotic arrest and apoptosis in HeLa and HepG2 cells.
2020,
Pubmed
Zhong,
Investigation of the interaction between the fate of antibiotics in aquafarms and their level in the environment.
2018,
Pubmed
