Click
here to close Hello! We notice that
you are using Internet Explorer, which is not supported by Echinobase
and may cause the site to display incorrectly. We suggest using a
current version of Chrome,
FireFox,
or Safari.
Invert Neurosci
1997 Jun 01;31:1-14. doi: 10.1007/BF02481710.
Show Gene links
Show Anatomy links
Nitric oxide signaling in invertebrates.
Jacklet JW
.
???displayArticle.abstract???
Nitric oxide (NO) is an unconventional neurotransmitter and neuromodulator molecule that is increasingly found to have important signaling functions in animals from nematodes to mammals. NO signaling mechanisms in the past were identified largely through experiments on mammals, after the discovery of NO's vasodilatory functions. The use of gene knock out mice has been particularly important in revealing the functions of the several isoforms of nitric oxide synthase (NOS), the enzyme that produces NO. Recent studies have revealed rich diversity in NO signaling. In addition to the well-established pathway in which NO activates guanylyl cyclase and cGMP production, redox mechanisms involving protein nitrosylation are important contributors to modulation of neurotransmitter release and reception. NO signaling studies in invertebrates are now generating a wealth of comparative information. Invertebrate NOS isoforms have been identified in insects and molluscs, and the conserved and variable amino acid sequences evaluated. Calcium-calmodulin dependence and cofactor requirements are conserved. NADPH diaphorase studies show that NOS is found in echinoderms, coelenterates, nematodes, annelids, insects, crustaceans and molluscs. Accumulating evidence reveals that NO is used as an orthograde transmitter and cotransmitter, and as a modulator of conventional transmitter release. NO appears to be used in diverse animals for certain neuronal functions, such as chemosensory signaling, learning, and development, suggesting that these NO functions have been conserved during evolution. The discovery of NO's diverse and unconventional signaling functions has stimulated a plethora of enthusiastic investigations into its uses. We can anticipate the discovery of many more interesting and some surprising NO signaling functions.
Arancio,
Nitric oxide acts directly in the presynaptic neuron to produce long-term potentiation in cultured hippocampal neurons.
1996, Pubmed
Arancio,
Nitric oxide acts directly in the presynaptic neuron to produce long-term potentiation in cultured hippocampal neurons.
1996,
Pubmed
Baumann,
Primary structure and functional expression of a Drosophila cyclic nucleotide-gated channel present in eyes and antennae.
1994,
Pubmed
Bowman,
Nitric oxide mediates the inhibitory effects of SDPNFLRFamide, a nematode FMRFamide-related neuropeptide, in Ascaris suum.
1995,
Pubmed
Bradley,
Functional expression of the heteromeric "olfactory" cyclic nucleotide-gated channel in the hippocampus: a potential effector of synaptic plasticity in brain neurons.
1997,
Pubmed
Bredt,
Nitric oxide, a novel neuronal messenger.
1992,
Pubmed
Bredt,
Nitric oxide: a physiologic messenger molecule.
1994,
Pubmed
Bredt,
Targeting nitric oxide to its targets.
1996,
Pubmed
Breer,
Implications of the NO/cGMP system for olfaction.
1993,
Pubmed
Broillet,
Beta subunits of the olfactory cyclic nucleotide-gated channel form a nitric oxide activated Ca2+ channel.
1997,
Pubmed
Chichery,
NADPH-diaphorase in a cephalopod brain (Sepia): presence in an analogue of the cerebellum.
1994,
Pubmed
Chiel,
An identified histaminergic neuron modulates feeding motor circuitry in Aplysia.
1986,
Pubmed
Colasanti,
NO in hydra feeding response.
1995,
Pubmed
Davis,
Long-term regulation of short-term transmitter release properties: retrograde signaling and synaptic development.
1994,
Pubmed
Dawson,
Nitric oxide synthase and neuronal NADPH diaphorase are identical in brain and peripheral tissues.
1991,
Pubmed
Dawson,
Gases as biological messengers: nitric oxide and carbon monoxide in the brain.
1994,
Pubmed
Delaney,
Waves and stimulus-modulated dynamics in an oscillating olfactory network.
1994,
Pubmed
Elofsson,
Is nitric oxide (NO) produced by invertebrate neurones?
1993,
Pubmed
Elphick,
Nitric oxide synthesis in locust olfactory interneurones.
1995,
Pubmed
Elphick,
New features of the locust optic lobe: evidence of a role for nitric oxide in insect vision.
1996,
Pubmed
Elphick,
Behavioral role for nitric oxide in chemosensory activation of feeding in a mollusc.
1995,
Pubmed
Elphick,
Nitric oxide synthesis and action in an invertebrate brain.
1993,
Pubmed
Ewer,
Neuropeptide induction of cyclic GMP increases in the insect CNS: resolution at the level of single identifiable neurons.
1994,
Pubmed
Garthwaite,
Glutamate, nitric oxide and cell-cell signalling in the nervous system.
1991,
Pubmed
Gelperin,
Nitric oxide mediates network oscillations of olfactory interneurons in a terrestrial mollusc.
1994,
Pubmed
Gibbs,
Nitric oxide and cyclic GMP regulate retinal patterning in the optic lobe of Drosophila.
1998,
Pubmed
Hope,
Neuronal NADPH diaphorase is a nitric oxide synthase.
1991,
Pubmed
Jacklet,
Co-localization of NADPH-diaphorase and myomodulin in synaptic glomeruli of Aplysia.
1994,
Pubmed
Jacklet,
Nitric oxide is used as an orthograde cotransmitter at identified histaminergic synapses.
1995,
Pubmed
Jia,
S-nitrosohaemoglobin: a dynamic activity of blood involved in vascular control.
1996,
Pubmed
Kendrick,
Formation of olfactory memories mediated by nitric oxide.
1997,
Pubmed
Kuzin,
Nitric oxide regulates cell proliferation during Drosophila development.
1996,
Pubmed
Lancaster,
Simulation of the diffusion and reaction of endogenously produced nitric oxide.
1994,
Pubmed
Lancaster,
A tutorial on the diffusibility and reactivity of free nitric oxide.
1997,
Pubmed
Leake,
Putative nitric oxide synthase (NOS)-containing cells in the central nervous system of the leech, Hirudo medicinalis: NADPH-diaphorase histochemistry.
1996,
Pubmed
Lev-Ram,
Long-term depression in cerebellar Purkinje neurons results from coincidence of nitric oxide and depolarization-induced Ca2+ transients.
1995,
Pubmed
Lev-Ram,
Synergies and coincidence requirements between NO, cGMP, and Ca2+ in the induction of cerebellar long-term depression.
1997,
Pubmed
Lin,
Nitric oxide modulation of quantal secretion in chick ciliary ganglia.
1994,
Pubmed
Lin,
NADPH-diaphorase activity changes during gangliogenesis and metamorphosis in the gastropod mollusc Ilyanassa obsoleta.
1996,
Pubmed
Lincoln,
Intracellular cyclic GMP receptor proteins.
1993,
Pubmed
Linden,
An evaluation of the nitric oxide/cGMP/cGMP-dependent protein kinase cascade in the induction of cerebellar long-term depression in culture.
1995,
Pubmed
Lipton,
A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds.
1993,
Pubmed
Luo,
Nitric oxide-dependent efflux of cGMP in rat cerebellar cortex: an in vivo microdialysis study.
1994,
Pubmed
Martínez,
Nitric oxide synthase in invertebrates.
1995,
Pubmed
Meffert,
Nitric oxide modulates synaptic vesicle docking fusion reactions.
1996,
Pubmed
Meulemans,
A nitric oxide synthase activity is involved in the modulation of acetylcholine release in Aplysia ganglion neurons: a histological, voltammetric and electrophysiological study.
1995,
Pubmed
Moroz,
From Polyplacophora to Cephalopoda: comparative analysis of nitric oxide signalling in mollusca.
1995,
Pubmed
Moroz,
Nitric oxide synthase-immunoreactive cells in the CNS and periphery of Lymnaea.
1994,
Pubmed
Moroz,
NADPH-diaphorase localization in the CNS and peripheral tissues of the predatory sea-slug Pleurobranchaea californica.
1996,
Pubmed
Moroz,
Nitric oxide synthase activity in the molluscan CNS.
1996,
Pubmed
Mothet,
Opposite actions of nitric oxide on cholinergic synapses: which pathways?
1996,
Pubmed
Mothet,
NO decreases evoked quantal ACh release at a synapse of Aplysia by a mechanism independent of Ca2+ influx and protein kinase G.
1996,
Pubmed
Müller,
Calcium-activated release of nitric oxide and cellular distribution of nitric oxide-synthesizing neurons in the nervous system of the locust.
1994,
Pubmed
Müller,
The nitric oxide system in insects.
1997,
Pubmed
Müller,
Ca2+/calmodulin-dependent nitric oxide synthase in Apis mellifera and Drosophila melanogaster.
1994,
Pubmed
Nussenzveig,
Nitric oxide loading of the salivary nitric-oxide-carrying hemoproteins (nitrophorins) in the blood-sucking bug Rhodnius prolixus.
1995,
Pubmed
Pan,
Nitric oxide-related species inhibit evoked neurotransmission but enhance spontaneous miniature synaptic currents in central neuronal cultures.
1996,
Pubmed
Rand,
Nitric oxide as a neurotransmitter in peripheral nerves: nature of transmitter and mechanism of transmission.
1995,
Pubmed
Regulski,
Molecular and biochemical characterization of dNOS: a Drosophila Ca2+/calmodulin-dependent nitric oxide synthase.
1995,
Pubmed
Ribeiro,
Reversible binding of nitric oxide by a salivary heme protein from a bloodsucking insect.
1993,
Pubmed
Salleo,
The discharge mechanism of acontial nematocytes involves the release of nitric oxide.
1996,
Pubmed
Savchenko,
Cyclic-nucleotide-gated channels mediate synaptic feedback by nitric oxide.
NULL,
Pubmed
Sawada,
Nitric oxide donor sodium nitroprusside inhibits the acetylcholine-induced K+ current in identified Aplysia neurons.
1996,
Pubmed
Sawada,
Nitric oxide induces an increased Na+ conductance in identified neurons of Aplysia.
1995,
Pubmed
Schmidt,
The nitric oxide and cGMP signal transduction system: regulation and mechanism of action.
1993,
Pubmed
Schmidt,
NO at work.
1994,
Pubmed
Scholz,
Nitric oxide and peptide neurohormones activate cGMP synthesis in the crab stomatogastric nervous system.
1996,
Pubmed
Schuman,
Nitric oxide and synaptic function.
1994,
Pubmed
Shah,
Two Drosophila genes that encode the alph and beta subunits of the brain soluble guanylyl cyclase.
1995,
Pubmed
Snyder,
Nitric oxide. No endothelial NO.
1995,
Pubmed
Son,
Long-term potentiation is reduced in mice that are doubly mutant in endothelial and neuronal nitric oxide synthase.
1996,
Pubmed
Stamler,
Biochemistry of nitric oxide and its redox-activated forms.
1992,
Pubmed
Stamler,
Redox signaling: nitrosylation and related target interactions of nitric oxide.
1994,
Pubmed
Stamler,
(S)NO signals: translocation, regulation, and a consensus motif.
1997,
Pubmed
Stengl,
NADPH diaphorase activity in the antennae of the hawkmoth Manduca sexta.
1996,
Pubmed
Sullivan,
Modification of hippocampal synaptic proteins by nitric oxide-stimulated ADP ribosylation.
1997,
Pubmed
Teyke,
Nitric oxide, but not serotonin, is involved in acquisition of food-attraction conditioning in the snail Helix pomatia.
1996,
Pubmed
Truman,
Nitric oxide-sensitive guanylate cyclase activity is associated with the maturational phase of neuronal development in insects.
1996,
Pubmed
Vincent,
Nitric oxide: a radical neurotransmitter in the central nervous system.
1994,
Pubmed
Weiss,
Modulatory synaptic actions of an identified histaminergic neuron on the serotonergic metacerebral cell of Aplysia.
1986,
Pubmed
Williams,
Correlation of nitric oxide synthase expression with changing patterns of axonal projections in the developing visual system.
1994,
Pubmed
Wolf,
Nitric oxide synthase in rat brain is predominantly located at neuronal endoplasmic reticulum: an electron microscopic demonstration of NADPH-diaphorase activity.
1992,
Pubmed
Wood,
Models of the diffusional spread of nitric oxide: implications for neural nitric oxide signalling and its pharmacological properties.
1994,
Pubmed