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J Struct Biol
2009 May 01;1662:133-43. doi: 10.1016/j.jsb.2009.02.001.
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Transient amorphous calcium phosphate in forming enamel.
Beniash E
,
Metzler RA
,
Lam RS
,
Gilbert PU
.
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Enamel, the hardest tissue in the body, begins as a three-dimensional network of nanometer size mineral particles, suspended in a protein gel. This mineral network serves as a template for mature enamel formation. To further understand the mechanisms of enamel formation we characterized the forming enamel mineral at an early secretory stage using X-ray absorption near-edge structure (XANES) spectromicroscopy, transmission electron microscopy (TEM), FTIR microspectroscopy and polarized light microscopy. We show that the newly formed enamel mineral is amorphous calcium phosphate (ACP), which eventually transforms into apatitic crystals. Interestingly, the size, shape and spatial organization of these amorphous mineral particles and older crystals are essentially the same, indicating that the mineral morphology and organization in enamel is determined prior to its crystallization. Mineralization via transient amorphous phases has been previously reported in chiton teeth, mollusk shells, echinoderm spicules and spines, and recent reports strongly suggest the presence of transient amorphous mineral in forming vertebrate bones. The present finding of transient ACP in murine tooth enamel suggests that this strategy might be universal.
Addadi,
Interactions between acidic proteins and crystals: stereochemical requirements in biomineralization.
1985, Pubmed
Addadi,
Interactions between acidic proteins and crystals: stereochemical requirements in biomineralization.
1985,
Pubmed
Aizenberg,
Direct fabrication of large micropatterned single crystals.
2003,
Pubmed
Aoba,
Changes in the nature and composition of enamel mineral during porcine amelogenesis.
1990,
Pubmed
Beniash,
Cellular control over spicule formation in sea urchin embryos: A structural approach.
1999,
Pubmed
,
Echinobase
Beniash,
The effect of recombinant mouse amelogenins on the formation and organization of hydroxyapatite crystals in vitro.
2005,
Pubmed
Bodier-Houllé,
High-resolution electron-microscopic study of the relationship between human enamel and dentin crystals at the dentinoenamel junction.
2000,
Pubmed
Boskey,
Amorphous calcium phosphate: the contention of bone.
1997,
Pubmed
Caterina,
Enamelysin (matrix metalloproteinase 20)-deficient mice display an amelogenesis imperfecta phenotype.
2002,
Pubmed
Chan,
Microbial polysaccharides template assembly of nanocrystal fibers.
2004,
Pubmed
Cölfen,
Higher-order organization by mesoscale self-assembly and transformation of hybrid nanostructures.
2003,
Pubmed
Crane,
Raman spectroscopic evidence for octacalcium phosphate and other transient mineral species deposited during intramembranous mineralization.
2006,
Pubmed
Cuisinier,
Human amelogenesis: high resolution electron microscopy of nanometer-sized particles.
1993,
Pubmed
Cuisinier,
Human amelogenesis. I: High resolution electron microscopy study of ribbon-like crystals.
1992,
Pubmed
De Stasio,
Compensation of charging in X-PEEM: a successful test on mineral inclusions in 4.4 Ga old zircon.
2003,
Pubmed
Diekwisch,
Subunit compartments of secretory stage enamel matrix.
1998,
Pubmed
Diekwisch,
Initial enamel crystals are not spatially associated with mineralized dentine.
1995,
Pubmed
Fincham,
The structural biology of the developing dental enamel matrix.
1999,
Pubmed
Fincham,
Self-assembly of a recombinant amelogenin protein generates supramolecular structures.
1994,
Pubmed
Frazer,
Spectromicroscope for the PHotoelectron Imaging of Nanostructures with X-rays (SPHINX): performance in biology, medicine and geology.
2004,
Pubmed
Fukae,
Micelle structure of amelogenin in porcine secretory enamel.
2007,
Pubmed
Gadaleta,
Fourier transform infrared spectroscopy of the solution-mediated conversion of amorphous calcium phosphate to hydroxyapatite: new correlations between X-ray diffraction and infrared data.
1996,
Pubmed
Gilbert,
Gradual ordering in red abalone nacre.
2008,
Pubmed
Grynpas,
Transient precursor strategy or very small biological apatite crystals?
2007,
Pubmed
Himpsel,
Fine structure of the Ca 2p x-ray-absorption edge for bulk compounds, surfaces, and interfaces.
1991,
Pubmed
Landis,
Earliest enamel deposits of the rat incisor examined by electron microscopy, electron diffraction, and electron probe microanalysis.
1988,
Pubmed
Lowenstam,
Minerals formed by organisms.
1981,
Pubmed
Lowenstam,
Transformation of amorphous calcium phosphate to crystalline dahillite in the radular teeth of chitons.
1985,
Pubmed
Mahamid,
Amorphous calcium phosphate is a major component of the forming fin bones of zebrafish: Indications for an amorphous precursor phase.
2008,
Pubmed
Margolis,
Role of macromolecular assembly of enamel matrix proteins in enamel formation.
2006,
Pubmed
Metzler,
Probing the organic-mineral interface at the molecular level in model biominerals.
2008,
Pubmed
,
Echinobase
Metzler,
Architecture of columnar nacre, and implications for its formation mechanism.
2007,
Pubmed
Moradian-Oldak,
On the formation of amelogenin microribbons.
2006,
Pubmed
Politi,
Transformation mechanism of amorphous calcium carbonate into calcite in the sea urchin larval spicule.
2008,
Pubmed
,
Echinobase
Politi,
Sea urchin spine calcite forms via a transient amorphous calcium carbonate phase.
2004,
Pubmed
,
Echinobase
Rey,
Resolution-enhanced Fourier transform infrared spectroscopy study of the environment of phosphate ion in the early deposits of a solid phase of calcium phosphate in bone and enamel and their evolution with age: 2. Investigations in the nu3PO4 domain.
1991,
Pubmed
Robinson,
Self-oriented assembly of nano-apatite particles: a subunit mechanism for building biological mineral crystals.
2007,
Pubmed
Robinson,
Subunit structures in hydroxyapatite crystal development in enamel: implications for amelogenesis imperfecta.
2003,
Pubmed
Simmer,
Expression, structure, and function of enamel proteinases.
2002,
Pubmed
Smith,
Cellular and chemical events during enamel maturation.
1998,
Pubmed
Termine,
Infrared analysis of rat bone: age dependency of amorphous and crystalline mineral fractions.
1966,
Pubmed
Towe,
Ultrastructure and development of iron mineralization in the radular teeth of Cryptochiton stelleri (Mollusca).
1967,
Pubmed
Weiner,
Transient precursor strategy in mineral formation of bone.
2006,
Pubmed
Weiner,
Structural biology. Choosing the crystallization path less traveled.
2005,
Pubmed
,
Echinobase
Weiss,
Mollusc larval shell formation: amorphous calcium carbonate is a precursor phase for aragonite.
2002,
Pubmed
Wiedemann-Bidlack,
pH triggered self-assembly of native and recombinant amelogenins under physiological pH and temperature in vitro.
2007,
Pubmed
Wilt,
The dynamics of secretion during sea urchin embryonic skeleton formation.
2008,
Pubmed
,
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