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The EML4-ALK transcript but not the fusion protein can be expressed in reactive and neoplastic lymphoid tissues.
Sozzi G
,
Martelli MP
,
Conte D
,
Modena P
,
Pettirossi V
,
Pileri SA
,
Falini B
.
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Rearrangements involving the ALK gene define two distinct entities in the new 2008 WHO classification of lymphoid neoplasms, i.e. ALK+ anaplastic large cell lymphoma and a rare subset of ALK+ diffuse large B-cell lymphoma. Recently, rearrangements involving ALK and the echinoderm microtubule associated protein-like 4 (EML4) gene were described as a specific genetic alteration in about 6% of non-small cell lung cancer (NSCLC). We investigated the expression of EML4-ALK mRNA and protein in 51 reactive and 58 neoplastic lymphoid tissues. EML4-ALK transcripts were detected in 3/51 (5.9%) of reactive lymphoid tissues and 12/58 (20.7%) of lymphomas of different categories, including follicular lymphoma, diffuse large B-cell lymphoma and Hodgkin's disease. Notably, none of these cases expressed the EML4-ALK fusion protein at Western blotting samples and immunohistochemistry. These results indicate that EML4-ALK rearrangements are not specific of NSCLC and raise yet unsolved questions about their role in promoting human neoplasms.
Benharroch,
ALK-positive lymphoma: a single disease with a broad spectrum of morphology.
1998, Pubmed
Benharroch,
ALK-positive lymphoma: a single disease with a broad spectrum of morphology.
1998,
Pubmed
Beylot-Barry,
Characterization of t(2;5) reciprocal transcripts and genomic breakpoints in CD30+ cutaneous lymphoproliferations.
1998,
Pubmed
Camilleri-Broët,
ALK is not expressed in Hodgkin disease.
2001,
Pubmed
Falini,
ALK expression defines a distinct group of T/null lymphomas ("ALK lymphomas") with a wide morphological spectrum.
1998,
Pubmed
Falini,
ALK+ lymphoma: clinico-pathological findings and outcome.
1999,
Pubmed
Falini,
Proteins encoded by genes involved in chromosomal alterations in lymphoma and leukemia: clinical value of their detection by immunocytochemistry.
2002,
Pubmed
Falini,
Lymphomas expressing ALK fusion protein(s) other than NPM-ALK.
1999,
Pubmed
Lawrence,
TPM3-ALK and TPM4-ALK oncogenes in inflammatory myofibroblastic tumors.
2000,
Pubmed
Maes,
The NPM-ALK and the ATIC-ALK fusion genes can be detected in non-neoplastic cells.
2001,
Pubmed
Martelli,
EML4-ALK rearrangement in non-small cell lung cancer and non-tumor lung tissues.
2009,
Pubmed
,
Echinobase
Morris,
Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma.
1994,
Pubmed
Orscheschek,
Large-cell anaplastic lymphoma-specific translocation (t[2;5] [p23;q35]) in Hodgkin's disease: indication of a common pathogenesis?
1995,
Pubmed
Pulford,
Detection of anaplastic lymphoma kinase (ALK) and nucleolar protein nucleophosmin (NPM)-ALK proteins in normal and neoplastic cells with the monoclonal antibody ALK1.
1997,
Pubmed
Pulford,
Biochemical detection of novel anaplastic lymphoma kinase proteins in tissue sections of anaplastic large cell lymphoma.
1999,
Pubmed
Rikova,
Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer.
2007,
Pubmed
Soda,
Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer.
2007,
Pubmed
,
Echinobase
Soda,
A mouse model for EML4-ALK-positive lung cancer.
2008,
Pubmed
Stein,
CD30(+) anaplastic large cell lymphoma: a review of its histopathologic, genetic, and clinical features.
2000,
Pubmed
Takeuchi,
Multiplex reverse transcription-PCR screening for EML4-ALK fusion transcripts.
2008,
Pubmed