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Russ Chem Bull
2013 Jan 01;623:836-843. doi: 10.1007/s11172-013-0113-2.
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Synthesis and antineoplastic properties of (1H-1,2,3-triazol-1-yl)furazans.
Kulikov AS
,
Epishina MA
,
Batog LV
,
Rozhkov VY
,
Makhova NN
,
Konyushkin LD
,
Semenova MN
,
Semenov VV
.
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A method of 3-amino-4-[5-aryl(heteroaryl)-1H-1,2,3-triazol-1-yl)]furazan synthesis was optimized. Condensation of these compounds with 2,5-dimethoxytetrahydrofuran resulted in a series of previously unknown 4-[5-aryl(heteroaryl)-1H-1,2,3-triazol-1-yl)]-3-(pyrrol-1-yl)furazans. All target compounds were evaluated for both antimitotic microtubule destabilizing effect in a phenotypic sea urchin embryo assay and cytotoxicity in a panel of 60 human cancer cell lines. Pyrrolyl derivatives of triazolylfurazans were determined as antiproliferative compounds. The most potent microtubule targeting compounds 7a and 7e are of interest for further trials as antineoplastic agents.
Beale,
Increased endothelial cell selectivity of triazole-bridged dihalogenated A-ring analogues of combretastatin A-1.
2012, Pubmed
Beale,
Increased endothelial cell selectivity of triazole-bridged dihalogenated A-ring analogues of combretastatin A-1.
2012,
Pubmed
Ferlin,
Synthesis and in vitro and in vivo antitumor activity of 2-phenylpyrroloquinolin-4-ones.
2005,
Pubmed
Kingston,
Tubulin-interactive natural products as anticancer agents.
2009,
Pubmed
Nam,
Combretastatin A-4 analogues as antimitotic antitumor agents.
2003,
Pubmed
Odlo,
1,5-Disubstituted 1,2,3-triazoles as cis-restricted analogues of combretastatin A-4: Synthesis, molecular modeling and evaluation as cytotoxic agents and inhibitors of tubulin.
2008,
Pubmed
Olesen,
Synthesis and in vitro characterization of 1-(4-aminofurazan-3-yl)-5-dialkylaminomethyl-1H-[1,2,3]triazole-4-carboxylic acid derivatives. A new class of selective GSK-3 inhibitors.
2003,
Pubmed
Pettit,
Antineoplastic agents 322. synthesis of combretastatin A-4 prodrugs.
1995,
Pubmed
Schmidt,
Sensitized detection of inhibitory fragments and iterative development of non-peptidic protease inhibitors by dynamic ligation screening.
2008,
Pubmed
Semenov,
Synthesis of antimitotic polyalkoxyphenyl derivatives of combretastatin using plant allylpolyalkoxybenzenes.
2010,
Pubmed
,
Echinobase
Semenova,
Sea urchin embryo as a model organism for the rapid functional screening of tubulin modulators.
2006,
Pubmed
,
Echinobase
Semenova,
Polyalkoxybenzenes from plants. 5. Parsley seed extract in synthesis of azapodophyllotoxins featuring strong tubulin destabilizing activity in the sea urchin embryo and cell culture assays.
2011,
Pubmed
,
Echinobase
Tron,
Synthesis and cytotoxic evaluation of combretafurazans.
2005,
Pubmed
Zhu,
Synthesis and herbicidal evaluation of novel 3-[(alpha-hydroxy-substituted)benzylidene]pyrrolidine-2,4-diones.
2005,
Pubmed
