Click
here to close Hello! We notice that
you are using Internet Explorer, which is not supported by Echinobase
and may cause the site to display incorrectly. We suggest using a
current version of Chrome,
FireFox,
or Safari.
Toxicol Res (Camb)
2020 Aug 12;94:537-543. doi: 10.1093/toxres/tfaa051.
Show Gene links
Show Anatomy links
Evaluation of dimethoate toxicity on fertilization and on embryonic development of Paracentrotus lividus (Lamarck, 1816).
Scalisi EM
,
Pecoraro R
,
Salvaggio A
,
Corsaro A
,
Messina G
,
Ignoto S
,
Lombardo BM
,
Brundo MV
.
???displayArticle.abstract???
Organophosphates are a large class of chemicals with anticholinesterase action insecticides. Dimethoate belongs to the class of organophosphates and it is used for agriculture purpose. Its main toxicological role in animals and humans is the inhibition of the activity of acetylcholinesterase. Although it is not considered genotoxic, carcinogenic and teratogen, there is evidence of increased pup mortality in developmental neurotoxicity studies. Since there is scant published literature about developmental toxicity, we investigated the adverse effects of dimethoate on fertilization and embryonic development in sea urchin (Paracentrotus lividus), a model organism widely used to assess the toxicity of contaminants on environmental matrices; so pesticide residues can be released into the environment, and could affect the health of organisms, including humans. Different solution of dimethoate (4 × 10-3, 4 × 10-4, 4 × 10-5, 4 × 10-6 and 4 × 10-7 g/10 ml) have been tested on spermatozoa of P. lividus to evaluate the fertilizing ability of them when we added egg cells untreated. We demonstrated that dimethoate does not interfere with fertilizing ability of spermatozoa but egg cells fertilized by treated spermatozoa showed alterations in the segmentation planes as asymmetric and/or asynchronous cell divisions.
Akbel,
The subchronic exposure to malathion, an organophosphate pesticide, causes lipid peroxidation, oxidative stress, and tissue damage in rats: the protective role of resveratrol.
2018, Pubmed
Akbel,
The subchronic exposure to malathion, an organophosphate pesticide, causes lipid peroxidation, oxidative stress, and tissue damage in rats: the protective role of resveratrol.
2018,
Pubmed
Aktar,
Impact of pesticides use in agriculture: their benefits and hazards.
2009,
Pubmed
Aldridge,
Organophosphorus compounds: molecular basis for their biological properties.
1981,
Pubmed
Antwi,
Toxicological effects of pyrethroids on non-target aquatic insects.
2015,
Pubmed
Ayed-Boussema,
Genotoxicity associated with oxidative damage in the liver and kidney of mice exposed to dimethoate subchronic intoxication.
2012,
Pubmed
Beiras,
Integrative assessment of marine pollution in Galician estuaries using sediment chemistry, mussel bioaccumulation, and embryo-larval toxicity bioassays.
2003,
Pubmed
,
Echinobase
Bellas,
Integrative assessment of coastal pollution in a Ría coastal system (Galicia, NW Spain): correspondence between sediment chemistry and toxicity.
2008,
Pubmed
,
Echinobase
Casida,
The ABCs of pesticide toxicology: amounts, biology, and chemistry.
2017,
Pubmed
Costa,
Serum paraoxonase and its influence on paraoxon and chlorpyrifos-oxon toxicity in rats.
1990,
Pubmed
Costa,
The neurotoxicity of organochlorine and pyrethroid pesticides.
2015,
Pubmed
Dinnel,
Improved methodology for a sea urchin sperm cell bioassay for marine waters.
1987,
Pubmed
,
Echinobase
Dinnel,
Comparative sensitivity of sea urchin sperm bioassays to metals and pesticides.
1989,
Pubmed
,
Echinobase
Erkmen,
Spermiotoxicity and embryotoxicity of permethrin in the sea urchin Paracentrotus lividus.
2015,
Pubmed
,
Echinobase
Gambardella,
Developmental abnormalities and changes in cholinesterase activity in sea urchin embryos and larvae from sperm exposed to engineered nanoparticles.
2013,
Pubmed
,
Echinobase
Gharred,
Assessment of toxic interactions between deltamethrin and copper on the fertility and developmental events in the Mediterranean sea urchin, Paracentrotus lividus.
2015,
Pubmed
,
Echinobase
Iyaniwura,
Health and environmental hazards of pesticides.
1991,
Pubmed
Kobayashi,
Effects of new antifouling compounds on the development of sea urchin.
2002,
Pubmed
,
Echinobase
Kroeker,
Response to technical comment on `meta-analysis reveals negative yet variable effects of ocean acidification on marine organisms'.
2011,
Pubmed
Manzo,
Sea urchin embryotoxicity test: proposal for a simplified bioassay.
2004,
Pubmed
,
Echinobase
Manzo,
Toxic effects of irgarol and diuron on sea urchin Paracentrotus lividus early development, fertilization, and offspring quality.
2006,
Pubmed
,
Echinobase
Pagano,
Cytogenetic, developmental, and biochemical effects of aluminum, iron, and their mixture in sea urchins and mussels.
1996,
Pubmed
,
Echinobase
Pandey,
Acute toxicity bioassay of dimethoate on freshwater airbreathing catfish, Heteropneustes fossilis (Bloch).
2009,
Pubmed
Paredes,
The use of cryopreserved sea urchin embryos (Paracentrotus lividus) in marine quality assessment.
2015,
Pubmed
,
Echinobase
Pesando,
Biological targets of neurotoxic pesticides analysed by alteration of developmental events in the Mediterranean sea urchin, Paracentrotus lividus.
2003,
Pubmed
,
Echinobase
Poet,
Physiologically based pharmacokinetic/pharmacodynamic model for the organophosphorus pesticide diazinon.
2004,
Pubmed
Scalisi,
Evaluation of dimethoate toxicity on fertilization and on embryonic development of Paracentrotus lividus (Lamarck, 1816).
2020,
Pubmed
Serafini,
Trypan blue/giemsa staining to assess sperm membrane integrity in salernitano stallions and its relationship to pregnancy rates.
2014,
Pubmed
Torres,
Screening the Toxicity of Selected Personal Care Products Using Embryo Bioassays: 4-MBC, Propylparaben and Triclocarban.
2016,
Pubmed
,
Echinobase
Wilt,
Developmental biology meets materials science: Morphogenesis of biomineralized structures.
2005,
Pubmed
,
Echinobase
Wu,
Copper oxide and zinc oxide nanomaterials act as inhibitors of multidrug resistance transport in sea urchin embryos: their role as chemosensitizers.
2015,
Pubmed
,
Echinobase