Click
here to close Hello! We notice that
you are using Internet Explorer, which is not supported by Echinobase
and may cause the site to display incorrectly. We suggest using a
current version of Chrome,
FireFox,
or Safari.
Eye (Lond)
2021 Oct 01;3510:2812-2819. doi: 10.1038/s41433-020-01317-9.
Show Gene links
Show Anatomy links
Phenotyping of retinal neovascularization in ischemic retinal vein occlusion using wide field OCT angiography.
Huemer J
,
Khalid H
,
Wagner SK
,
Nicholson L
,
Fu DJ
,
Sim DA
,
Patel PJ
,
Balaskas K
,
Rajendram R
,
Keane PA
.
???displayArticle.abstract???
BACKGROUND/OBJECTIVES: Abnormal retinal neovascularization caused by ischemic retinal vein occlusion (RVO) is a frequent cause of visually significant vitreous hemorrhage. The early detection of new vessels may be challenging and often requires the use of invasive tests such as fundus fluorescein angiography (FA). We demonstrate the use of wide-field optical coherence tomography angiography (WF-OCTA) in the detection and characterization of neovascularization secondary to ischemic RVO.
SUBJECTS/METHODS: We conducted a retrospective observational case series of patients diagnosed with ischemic RVO between August 2018 and March 2019, who underwent WF-SS-OCTA imaging (PLEX Elite 9000, Carl Zeiss Meditec). We performed real-life montage imaging, covering the involved area and compared the findings of WF-SS-OCTA to standard clinical examination and when available, ultrawide-field fluorescein angiography (UWF-FA, Optos 200TX).
RESULTS: In the included 39 eyes with ischemic RVO, neovascularization elsewhere (NVE) was encountered in 16 of 39 eyes (41%) on WF-OCTA and were characterized as sea-fan type vessels and nodular type vessels, based on their appearance and localization. NVE was identified in 4/39 eyes on standard clinical examination, equating to a detection rate of 10.3%. All were of a sea-fan morphology. In one case, NVE found on WF-OCTA was not observed on UWF-FA, which was a nodular type. Neovascularization of the disc (NVD) was detected in one eye.
CONCLUSIONS: WF-OCTA may become a useful noninvasive tool in the detection of neovascularization in patients with ischemic RVO. Furthermore, the characterization of different morphologies of neovascularization detected by WF-OCTA could be of clinical relevance.
Arsene,
Conversion from nonischemic to ischemic retinal vein occlusion: prediction by venous velocity on color Doppler imaging.
2009, Pubmed
Arsene,
Conversion from nonischemic to ischemic retinal vein occlusion: prediction by venous velocity on color Doppler imaging.
2009,
Pubmed
Brennan,
Statistical methods for assessing observer variability in clinical measures.
1992,
Pubmed
Chan,
SCORE Study report #11: incidences of neovascular events in eyes with retinal vein occlusion.
2011,
Pubmed
Finkelstein,
Branch vein occlusion. Retinal neovascularization outside the involved segment.
1982,
Pubmed
Gao,
Optical Coherence Tomography Angiography.
2016,
Pubmed
Hayreh,
Differentiation of ischemic from non-ischemic central retinal vein occlusion during the early acute phase.
1990,
Pubmed
Hayreh,
Fundus changes in branch retinal vein occlusion.
2015,
Pubmed
Hayreh,
Argon laser scatter photocoagulation in treatment of branch retinal vein occlusion. A prospective clinical trial.
1993,
Pubmed
Hayreh,
Incidence of various types of retinal vein occlusion and their recurrence and demographic characteristics.
1994,
Pubmed
Hirano,
Wide-field en face swept-source optical coherence tomography angiography using extended field imaging in diabetic retinopathy.
2018,
Pubmed
Jia,
Quantitative optical coherence tomography angiography of vascular abnormalities in the living human eye.
2015,
Pubmed
Keane,
Retinal imaging in the twenty-first century: state of the art and future directions.
2014,
Pubmed
Laatikainen,
Panretinal photocoagulation in central retinal vein occlusion: A randomised controlled clinical study.
1977,
Pubmed
Magargal,
Neovascular glaucoma following central retinal vein obstruction.
1981,
Pubmed
Mendis,
Correlation of histologic and clinical images to determine the diagnostic value of fluorescein angiography for studying retinal capillary detail.
2010,
Pubmed
Minturn,
Progression of nonischemic central retinal vein obstruction to the ischemic variant.
1986,
Pubmed
NULL,
Argon laser scatter photocoagulation for prevention of neovascularization and vitreous hemorrhage in branch vein occlusion. A randomized clinical trial. Branch Vein Occlusion Study Group.
1986,
Pubmed
NULL,
A randomized clinical trial of early panretinal photocoagulation for ischemic central vein occlusion. The Central Vein Occlusion Study Group N report.
1995,
Pubmed
Nicholson,
Retinal Nonperfusion in the Posterior Pole Is Associated With Increased Risk of Neovascularization in Central Retinal Vein Occlusion.
2017,
Pubmed
Nobre Cardoso,
Systematic Evaluation of Optical Coherence Tomography Angiography in Retinal Vein Occlusion.
2016,
Pubmed
Rogers,
The prevalence of retinal vein occlusion: pooled data from population studies from the United States, Europe, Asia, and Australia.
2010,
Pubmed
Sawada,
Comparison between wide-angle OCT angiography and ultra-wide field fluorescein angiography for detecting non-perfusion areas and retinal neovascularization in eyes with diabetic retinopathy.
2018,
Pubmed
Schwartz,
Objective Evaluation of Proliferative Diabetic Retinopathy Using OCT.
2020,
Pubmed
Shilling,
New vessel formation in retinal branch vein occlusion.
1976,
Pubmed
Shiraki,
Evaluation of retinal nonperfusion in branch retinal vein occlusion using wide-field optical coherence tomography angiography.
2019,
Pubmed
Spaide,
Retinal vascular layers imaged by fluorescein angiography and optical coherence tomography angiography.
2015,
Pubmed
Yannuzzi,
Fluorescein angiography complication survey.
1986,
Pubmed
Zegarra,
The natural course of central retinal vein occlusion.
1979,
Pubmed
de Carlo,
Evaluation of Preretinal Neovascularization in Proliferative Diabetic Retinopathy Using Optical Coherence Tomography Angiography.
2016,
Pubmed