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Mar Drugs
2021 Jul 26;198:. doi: 10.3390/md19080412.
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Multifaceted Clinical Effects of Echinochrome.
Kim HK
,
Vasileva EA
,
Mishchenko NP
,
Fedoreyev SA
,
Han J
.
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The marine drug histochrome is a special natural antioxidant. The active substance of the drug is echinochrome A (Ech A, 7-ethyl-2,3,5,6,8-pentahydroxy-1,4-naphthoquinone), the most abundant quinonoid pigment in sea urchins. The medicine is clinically used in cardiology and ophthalmology based on the unique properties of Ech A, which simultaneously block various links of free radical reactions. In the last decade, numerous studies have demonstrated the effectiveness of histochrome in various disease models without adverse effects. Here, we review the data on the various clinical effects and modes of action of Ech A in ophthalmic, cardiovascular, cerebrovascular, inflammatory, metabolic, and malignant diseases.
2018R1D1A1A09081767 National Research Foundation of Korea, 2020R1A4A1018943 National Research Foundation of Korea, 2018R1A2A3074998 National Research Foundation of Korea
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