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Science
2018 Oct 19;3626412:339-343. doi: 10.1126/science.aau3301.
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Supracellular contraction at the rear of neural crest cell groups drives collective chemotaxis.
Shellard A
,
Szabó A
,
Trepat X
,
Mayor R
.
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Collective cell chemotaxis, the directed migration of cell groups along gradients of soluble chemical cues, underlies various developmental and pathological processes. We use neural crest cells, a migratory embryonic stem cell population whose behavior has been likened to malignant invasion, to study collective chemotaxis in vivo. Studying Xenopus and zebrafish, we have shown that the neural crest exhibits a tensile actomyosin ring at the edge of the migratory cell group that contracts in a supracellular fashion. This contractility is polarized during collective cell chemotaxis: It is inhibited at the front but persists at the rear of the cell cluster. The differential contractility drives directed collective cell migration ex vivo and in vivo through the intercalation of rear cells. Thus, in neural crest cells, collective chemotaxis works by rear-wheel drive.
Bahm,
PDGF controls contact inhibition of locomotion by regulating N-cadherin during neural crest migration.
2017, Pubmed
Bahm,
PDGF controls contact inhibition of locomotion by regulating N-cadherin during neural crest migration.
2017,
Pubmed
Cai,
Mechanical feedback through E-cadherin promotes direction sensing during collective cell migration.
2014,
Pubmed
Carmona-Fontaine,
Contact inhibition of locomotion in vivo controls neural crest directional migration.
2008,
Pubmed
Donà,
Directional tissue migration through a self-generated chemokine gradient.
2013,
Pubmed
Friedl,
Collective cell migration in morphogenesis, regeneration and cancer.
2009,
Pubmed
Gilmour,
From morphogen to morphogenesis and back.
2017,
Pubmed
Haas,
Chemokine signaling mediates self-organizing tissue migration in the zebrafish lateral line.
2006,
Pubmed
Haeger,
Collective cell migration: guidance principles and hierarchies.
2015,
Pubmed
Hidalgo-Carcedo,
Collective cell migration requires suppression of actomyosin at cell-cell contacts mediated by DDR1 and the cell polarity regulators Par3 and Par6.
2011,
Pubmed
Insall,
Understanding eukaryotic chemotaxis: a pseudopod-centred view.
2010,
Pubmed
Kaucka,
Analysis of neural crest-derived clones reveals novel aspects of facial development.
2016,
Pubmed
Kerosuo,
What is bad in cancer is good in the embryo: importance of EMT in neural crest development.
2012,
Pubmed
Kruse,
Asters, vortices, and rotating spirals in active gels of polar filaments.
2004,
Pubmed
Majumdar,
New paradigms in the establishment and maintenance of gradients during directed cell migration.
2014,
Pubmed
Mayor,
The front and rear of collective cell migration.
2016,
Pubmed
O'Neill,
Membrane Flow Drives an Adhesion-Independent Amoeboid Cell Migration Mode.
2018,
Pubmed
Paluch,
The role and regulation of blebs in cell migration.
2013,
Pubmed
Petrie,
Multiple mechanisms of 3D migration: the origins of plasticity.
2016,
Pubmed
Reffay,
Interplay of RhoA and mechanical forces in collective cell migration driven by leader cells.
2014,
Pubmed
Roca-Cusachs,
Mechanical guidance of cell migration: lessons from chemotaxis.
2013,
Pubmed
Szabó,
In vivo confinement promotes collective migration of neural crest cells.
2016,
Pubmed
Theveneau,
Collective cell migration of the cephalic neural crest: the art of integrating information.
2011,
Pubmed
Theveneau,
Collective chemotaxis requires contact-dependent cell polarity.
2010,
Pubmed
Uroz,
Regulation of cell cycle progression by cell-cell and cell-matrix forces.
2018,
Pubmed
Valon,
Optogenetic control of cellular forces and mechanotransduction.
2017,
Pubmed
Voituriez,
Generic phase diagram of active polar films.
2006,
Pubmed
Wang,
Light-mediated activation reveals a key role for Rac in collective guidance of cell movement in vivo.
2010,
Pubmed
Welch,
Cell migration, freshly squeezed.
2015,
Pubmed
Zajac,
Tumour spheres with inverted polarity drive the formation of peritoneal metastases in patients with hypermethylated colorectal carcinomas.
2018,
Pubmed
