Click
here to close Hello! We notice that
you are using Internet Explorer, which is not supported by Echinobase
and may cause the site to display incorrectly. We suggest using a
current version of Chrome,
FireFox,
or Safari.
Dev Cell
2012 Feb 14;222:255-67. doi: 10.1016/j.devcel.2011.12.011.
Show Gene links
Show Anatomy links
The cell adhesion molecule echinoid functions as a tumor suppressor and upstream regulator of the Hippo signaling pathway.
Yue T
,
Tian A
,
Jiang J
.
???displayArticle.abstract???
The Hippo (Hpo) signaling pathway controls tissue growth and organ size in species ranging from Drosophila to mammals and is deregulated in a wide range of human cancers. The core pathway consists of the Hpo/Warts (Wts) kinase cassette that phosphorylates and inactivates the transcriptional coactivator Yorkie (Yki). Here, we report that Echinoid (Ed), an immunoglobulin domain-containing cell adhesion molecule, acts as an upstream regulator of the Hpo pathway. Loss of Ed compromises Yki phosphorylation, resulting in elevated Yki activity that increases Hpo target gene expression and drives tissue overgrowth. Ed physically interacts with and stabilizes the Hpo-binding partner Salvador (Sav) at adherens junctions. Ed/Sav interaction is promoted by cell-cell contact and requires dimerization of Ed cytoplasmic domain. Overexpression of Sav or dimerized Ed cytoplasmic domain suppressed loss-of-Ed phenotypes. We propose that Ed may link cell-cell contact to Hpo signaling through binding and stabilizing Sav, thus modulating the Hpo kinase activity.
Badouel,
The FERM-domain protein Expanded regulates Hippo pathway activity via direct interactions with the transcriptional activator Yorkie.
2009, Pubmed
Badouel,
The FERM-domain protein Expanded regulates Hippo pathway activity via direct interactions with the transcriptional activator Yorkie.
2009,
Pubmed
Bai,
The cell adhesion molecule Echinoid defines a new pathway that antagonizes the Drosophila EGF receptor signaling pathway.
2001,
Pubmed
Baumgartner,
The WW domain protein Kibra acts upstream of Hippo in Drosophila.
2010,
Pubmed
Bennett,
Fat cadherin modulates organ size in Drosophila via the Salvador/Warts/Hippo signaling pathway.
2006,
Pubmed
Brennecke,
bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila.
2003,
Pubmed
Chen,
The apical-basal cell polarity determinant Crumbs regulates Hippo signaling in Drosophila.
2010,
Pubmed
Cho,
Delineation of a Fat tumor suppressor pathway.
2006,
Pubmed
Dong,
Elucidation of a universal size-control mechanism in Drosophila and mammals.
2007,
Pubmed
Fetting,
The cell adhesion molecules Echinoid and Friend of Echinoid coordinate cell adhesion and cell signaling to regulate the fidelity of ommatidial rotation in the Drosophila eye.
2009,
Pubmed
Fukuhara,
Association of a lung tumor suppressor TSLC1 with MPP3, a human homologue of Drosophila tumor suppressor Dlg.
2003,
Pubmed
Genevet,
The Hippo pathway and apico-basal cell polarity.
2011,
Pubmed
Genevet,
Kibra is a regulator of the Salvador/Warts/Hippo signaling network.
2010,
Pubmed
Goulev,
SCALLOPED interacts with YORKIE, the nuclear effector of the hippo tumor-suppressor pathway in Drosophila.
2008,
Pubmed
Grzeschik,
Lgl, aPKC, and Crumbs regulate the Salvador/Warts/Hippo pathway through two distinct mechanisms.
2010,
Pubmed
Halder,
Hippo signaling: growth control and beyond.
2011,
Pubmed
Halder,
Eyeless initiates the expression of both sine oculis and eyes absent during Drosophila compound eye development.
1998,
Pubmed
Hamaratoglu,
The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis.
2006,
Pubmed
Harvey,
The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis.
2003,
Pubmed
Hergovich,
Human NDR kinases are rapidly activated by MOB proteins through recruitment to the plasma membrane and phosphorylation.
2005,
Pubmed
Huang,
The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP.
2005,
Pubmed
Islam,
Neuroglian activates Echinoid to antagonize the Drosophila EGF receptor signaling pathway.
2003,
Pubmed
Jia,
The Drosophila Ste20 family kinase dMST functions as a tumor suppressor by restricting cell proliferation and promoting apoptosis.
2003,
Pubmed
Justice,
The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation.
1995,
Pubmed
Kango-Singh,
Shar-pei mediates cell proliferation arrest during imaginal disc growth in Drosophila.
2002,
Pubmed
Kuramochi,
TSLC1 is a tumor-suppressor gene in human non-small-cell lung cancer.
2001,
Pubmed
Lai,
Control of cell proliferation and apoptosis by mob as tumor suppressor, mats.
2005,
Pubmed
Ling,
The apical transmembrane protein Crumbs functions as a tumor suppressor that regulates Hippo signaling by binding to Expanded.
2010,
Pubmed
Maitra,
The tumor suppressors Merlin and Expanded function cooperatively to modulate receptor endocytosis and signaling.
2006,
Pubmed
Masuda,
The tumor suppressor protein TSLC1 is involved in cell-cell adhesion.
2002,
Pubmed
Matakatsu,
Separating the adhesive and signaling functions of the Fat and Dachsous protocadherins.
2006,
Pubmed
Meignin,
The salvador-warts-hippo pathway is required for epithelial proliferation and axis specification in Drosophila.
2007,
Pubmed
Motzny,
The Drosophila cubitus interruptus protein and its role in the wingless and hedgehog signal transduction pathways.
1995,
Pubmed
Murakami,
Involvement of a cell adhesion molecule, TSLC1/IGSF4, in human oncogenesis.
2005,
Pubmed
Newsome,
Analysis of Drosophila photoreceptor axon guidance in eye-specific mosaics.
2000,
Pubmed
O'Shea,
X-ray structure of the GCN4 leucine zipper, a two-stranded, parallel coiled coil.
1991,
Pubmed
Oh,
In vivo regulation of Yorkie phosphorylation and localization.
2008,
Pubmed
Pan,
The hippo signaling pathway in development and cancer.
2010,
Pubmed
Pantalacci,
The Salvador partner Hippo promotes apoptosis and cell-cycle exit in Drosophila.
2003,
Pubmed
Pellock,
The Drosophila tumor suppressors Expanded and Merlin differentially regulate cell cycle exit, apoptosis, and Wingless signaling.
2007,
Pubmed
Polesello,
Salvador-warts-hippo signaling promotes Drosophila posterior follicle cell maturation downstream of notch.
2007,
Pubmed
Ren,
Hippo signaling regulates Yorkie nuclear localization and activity through 14-3-3 dependent and independent mechanisms.
2010,
Pubmed
Robinson,
Crumbs regulates Salvador/Warts/Hippo signaling in Drosophila via the FERM-domain protein Expanded.
2010,
Pubmed
Silva,
The tumor-suppressor gene fat controls tissue growth upstream of expanded in the hippo signaling pathway.
2006,
Pubmed
Spencer,
Echinoid is essential for regulation of Egfr signaling and R8 formation during Drosophila eye development.
2003,
Pubmed
Tapon,
salvador Promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines.
2002,
Pubmed
Thompson,
The Hippo pathway regulates the bantam microRNA to control cell proliferation and apoptosis in Drosophila.
2006,
Pubmed
Udan,
Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway.
2003,
Pubmed
Wei,
Mob as tumor suppressor is activated by Hippo kinase for growth inhibition in Drosophila.
2007,
Pubmed
Wei,
Echinoid is a component of adherens junctions that cooperates with DE-Cadherin to mediate cell adhesion.
2005,
Pubmed
Willecke,
The fat cadherin acts through the hippo tumor-suppressor pathway to regulate tissue size.
2006,
Pubmed
Wu,
hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts.
2003,
Pubmed
Wu,
The TEAD/TEF family protein Scalloped mediates transcriptional output of the Hippo growth-regulatory pathway.
2008,
Pubmed
Xu,
Identifying tumor suppressors in genetic mosaics: the Drosophila lats gene encodes a putative protein kinase.
1995,
Pubmed
Yageta,
Direct association of TSLC1 and DAL-1, two distinct tumor suppressor proteins in lung cancer.
2002,
Pubmed
Yu,
The hippo pathway promotes Notch signaling in regulation of cell differentiation, proliferation, and oocyte polarity.
2008,
Pubmed
Yu,
Kibra functions as a tumor suppressor protein that regulates Hippo signaling in conjunction with Merlin and Expanded.
2010,
Pubmed
Zhang,
The TEAD/TEF family of transcription factor Scalloped mediates Hippo signaling in organ size control.
2008,
Pubmed
Zhang,
Hippo signaling pathway and organ size control.
2009,
Pubmed
Zhang,
Multiple Ser/Thr-rich degrons mediate the degradation of Ci/Gli by the Cul3-HIB/SPOP E3 ubiquitin ligase.
2009,
Pubmed
Zhao,
The Hippo-YAP pathway in organ size control and tumorigenesis: an updated version.
2010,
Pubmed
Zhao,
Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control.
2007,
Pubmed
