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Jpn J Cancer Res
2002 Jan 01;931:85-92. doi: 10.1111/j.1349-7006.2002.tb01204.x.
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Anti-tumor effect of chemically synthesized sulfolipids based on sea urchin''s natural sulfonoquinovosylmonoacylglycerols.
Sahara H
,
Hanashima S
,
Yamazaki T
,
Takahashi S
,
Sugawara F
,
Ohtani S
,
Ishikawa M
,
Mizushina Y
,
Ohta K
,
Shimozawa K
,
Gasa S
,
Jimbow K
,
Sakaguchi K
,
Sato N
,
Takahashi N
.
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We recently reported that 3''-sulfonoquinovosyl-1''-monoacylglycerol (designated A-5) extracted from sea urchin intestine was effective in suppressing the growth of solid tumors. Although the major fatty acid component of A-5 was a saturated C(16) acid, there were five other fatty acids, 14:0, 18:0, 14:1, 16:1, and 18:1, which constitute minor components of A-5. Therefore, it remains unclear as to which of these six fatty acid components of A-5 has the anti-tumor effect. In this study, we synthesized sulfolipids each containing only one of these six fatty acids and tested their cytotoxicity against tumor cells and in vivo anti-tumor effects on nude-mice bearing solid tumors of human lung adenocarcinoma cell line A-549. The IC(50) values of all products against tumor cells were more than 10(-5) M, suggesting weak cytotoxic activity compared with other chemotherapeutic compounds for cancer. On the other hand, in vivo anti-tumor assay showed that sulfoquinovosylmonoacylglycerols (SQMG) composed of 14:1 and 18:1 (designated SQMG(14:1) and SQMG(18:1), respectively) were significantly effective in suppressing the growth of solid tumors. Our data suggested that these two SQMGs had a substantial anti-tumor effect in vivo, and they are of interest as candidate drugs for anti-cancer treatment.
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