ECB-ART-47537
J Nat Prod
2001 Nov 01;6411:1468-70. doi: 10.1021/np010203g.
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Cacofurans A and B, new furanoditerpenes from a marine sponge.
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Two new labdane-class diterpenes, cacofurans A (1) and B (2), have been isolated from a sponge Cacospongia sp. Their structures were determined by analyzing spectroscopic data, by chemical transformations, and by X-ray diffraction. Cacofurans 1 and 2 inhibited the development of fertilized sea urchin eggs at concentrations of 0.5 and 5 microg/mL and showed an actin-disrupting effect on the NBT-II cell line at 10 microg/mL.
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Genes referenced: LOC100887844 LOC115919910 LOC590297