Click
here to close Hello! We notice that
you are using Internet Explorer, which is not supported by Echinobase
and may cause the site to display incorrectly. We suggest using a
current version of Chrome,
FireFox,
or Safari.
Mar Drugs
2019 Oct 11;1710:. doi: 10.3390/md17100577.
Show Gene links
Show Anatomy links
Pharmacokinetic Study of Bioactive Glycopeptide from Strongylocentrotus droebachiensis After Intranasal Administration to Rats Using Biomarker Approach.
Shikov AN
,
Pozharitskaya ON
,
Faustova NM
,
Kosman VM
,
Makarov VG
,
Razzazi-Fazeli E
,
Novak J
.
???displayArticle.abstract???
A glycopeptide fraction (GPF) from internal organs of green sea urchins (Strongylocentrotus droebachiensis Müller, Strongylocentrotidae) has been reported to be an effective bronchitis treatment. In this study, we evaluated the pharmacokinetic and tissue distribution of GPF, following single and repeated intranasal (i/n) administration over the course of seven days in rats. The method measuring lactate dehydrogenase as biomarker was used to analyse the plasma and tissue concentrations of GPF. GPF appears in the plasma 15 min after single i/n administration (100 µg/kg) and reaches its maximum at 45 min. The area under the curve (AUC)0-24 and Cmax were similar using both i/n and intravenous administration, while mean residence time (MRT) and T1/2 after i/n administration were significantly higher compared with intravenous (i/v) administration. The absolute bioavailability of GPF after i/n administration was 89%. The values of tissue availability (ft) provided evidence about the highest concentration of GPF in the nose mucosa (ft = 34.9), followed by spleen (ft = 4.1), adrenal glands (ft = 3.8), striated muscle (ft = 1.8), kidneys (ft = 0.5), and liver (ft = 0.3). After repeated dose administration, GPF exhibited significantly higher AUC0-24 and MRT, indicating its accumulation in the plasma.
Figure 1. The calibration curve for the calculation of glycopeptide fraction (GPF) in plasma. LDH, lactate dehydrogenase.
Figure 2. (A) The mean plasma profiles of GPF after intravenous (i/v) administration and intranasal (i/n) administration in dose 100 µg/kg to the rats (n = 5), (B) The mean tissues profiles of GPF after i/n administration (100 µg/kg) to the rats (n = 5).
Figure 3. Tissue availability of GPF after i/n administration in dose 100 µg/kg to the rats.
Figure 4. The mean plasma profiles of GPF after i/n administration to the rats after single (100 µg/kg) and repeated doses (3 × 100 µg/kg during seven consecutive days).
Bara,
Comparative pharmacokinetics of a low molecular weight heparin (PK 10 169) and unfractionated heparin after intravenous and subcutaneous administration.
1985, Pubmed
Bara,
Comparative pharmacokinetics of a low molecular weight heparin (PK 10 169) and unfractionated heparin after intravenous and subcutaneous administration.
1985,
Pubmed
Björn,
Anti-infectious and anti-inflammatory effects of peptide fragments sequentially derived from the antimicrobial peptide centrocin 1 isolated from the green sea urchin, Strongylocentrotus droebachiensis.
2012,
Pubmed
,
Echinobase
Bockus,
Form and function in cyclic peptide natural products: a pharmacokinetic perspective.
2013,
Pubmed
Brasseur,
Identification and quantification of spinochromes in body compartments of Echinometra mathaei's coloured types.
2018,
Pubmed
,
Echinobase
Drent,
Usefulness of lactate dehydrogenase and its isoenzymes as indicators of lung damage or inflammation.
1996,
Pubmed
Gancheva,
Effects of intranasal insulin on hepatic fat accumulation and energy metabolism in humans.
2015,
Pubmed
Gao,
Production of keto-disaccharides from aldo-disaccharides in subcritical aqueous ethanol.
2016,
Pubmed
Han,
The antimicrobial effect of CEN1HC-Br against Propionibacterium acnes and its therapeutic and anti-inflammatory effects on acne vulgaris.
2018,
Pubmed
,
Echinobase
Haug,
Antibacterial activity in Strongylocentrotus droebachiensis (Echinoidea), Cucumaria frondosa (Holothuroidea), and Asterias rubens (Asteroidea).
2002,
Pubmed
,
Echinobase
Hou,
Naphthoquinones of the spinochrome class: occurrence, isolation, biosynthesis and biomedical applications.
2018,
Pubmed
,
Echinobase
Jiao,
Polysaccharide Constituents of Three Types of Sea Urchin Shells and Their Anti-Inflammatory Activities.
2015,
Pubmed
,
Echinobase
Li,
Absorption and Transport of Sea Cucumber Saponins from Apostichopus japonicus.
2016,
Pubmed
,
Echinobase
Li,
Centrocins: isolation and characterization of novel dimeric antimicrobial peptides from the green sea urchin, Strongylocentrotus droebachiensis.
2010,
Pubmed
,
Echinobase
Li,
Strongylocins, novel antimicrobial peptides from the green sea urchin, Strongylocentrotus droebachiensis.
2008,
Pubmed
,
Echinobase
Mire-Sluis,
Progress in the use of biological assays during the development of biotechnology products.
2001,
Pubmed
Nguyen,
Dynamics of Erythropoietic Biomarkers in Response to Treatment With Erythropoietin in Belgrade Rats.
2018,
Pubmed
Pearson,
Nasal Administration and Plasma Pharmacokinetics of Parathyroid Hormone Peptide PTH 1-34 for the Treatment of Osteoporosis.
2019,
Pubmed
Pettit,
Antineoplastic agents. 76. The sea urchin Strongylocentrotus droebachiensis.
1981,
Pubmed
,
Echinobase
Pozharitskaya,
Pharmacokinetic and Tissue Distribution of Fucoidan from Fucus vesiculosus after Oral Administration to Rats.
2018,
Pubmed
Prokopov,
Animal-derived medicinal products in Russia: Current nomenclature and specific aspects of quality control.
2019,
Pubmed
Samaridou,
Nose-to-brain peptide delivery - The potential of nanotechnology.
2018,
Pubmed
Shikov,
Chemical Profiling and Bioactivity of Body Wall Lipids from Strongylocentrotus droebachiensis.
2017,
Pubmed
,
Echinobase
Solstad,
Novel Antimicrobial Peptides EeCentrocins 1, 2 and EeStrongylocin 2 from the Edible Sea Urchin Echinus esculentus Have 6-Br-Trp Post-Translational Modifications.
2016,
Pubmed
,
Echinobase
Talalaeva,
[Identification of histochrome metabolism products in urine for studying drug pharmacokinetics].
2014,
Pubmed
Tang,
Pharmacokinetic aspects of biotechnology products.
2004,
Pubmed
van Kesteren,
Pharmacokinetics and pharmacodynamics of the novel marine-derived anticancer agent ecteinascidin 743 in a phase I dose-finding study.
2000,
Pubmed
Zakirova,
[Pharmacokinetics and clinical efficacy of histochrome in patients with acute myocardial infarction].
1997,
Pubmed
Zhang,
Simultaneous Determination of Fucoxanthin and Its Deacetylated Metabolite Fucoxanthinol in Rat Plasma by Liquid Chromatography-Tandem Mass Spectrometry.
2015,
Pubmed
