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Mar Drugs
2019 Aug 28;179:. doi: 10.3390/md17090501.
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Echinochrome A Attenuates Cerebral Ischemic Injury through Regulation of Cell Survival after Middle Cerebral Artery Occlusion in Rat.
Kim R
,
Hur D
,
Kim HK
,
Han J
,
Mishchenko NP
,
Fedoreyev SA
,
Stonik VA
,
Chang W
.
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Of late, researchers have taken interest in alternative medicines for the treatment of brain ischemic stroke, where full recovery is rarely seen despite advanced medical technologies. Due to its antioxidant activity, Echinochrome A (Ech A), a natural compound found in sea urchins, has acquired attention as an alternative clinical trial source for the treatment of ischemic stroke. The current study demonstrates considerable potential of Ech A as a medication for cerebral ischemic injury. To confirm the effects of Ech A on the recovery of the injured region and behavioral decline, Ech A was administered through the external carotid artery in a rat middle cerebral artery occlusion model after reperfusion. The expression level of cell viability-related factors was also examined to confirm the mechanism of brain physiological restoration. Based on the results obtained, we propose that Ech A ameliorates the physiological deterioration by its antioxidant effect which plays a protective role against cell death, subsequent to post cerebral ischemic stroke.
Figure 3. Ech A treatment in cerebral injured brain alters the expression levels of cell viability-related factors. (A) The protein expression levels of cell survival and death regulators, such as Bcl-2, caspase-3, and Bax. (B) The protein expression levels of key players in vital cellular function regulation pathways, such as ERK and AKT. (C) The mRNA expression level of BDNF, supporting cell survival alteration in the injured brain region (* p < 0.05).
Ai,
Guhong injection protects against focal cerebral ischemia-reperfusion injury via anti-inflammatory effects in rats.
2017, Pubmed
Ai,
Guhong injection protects against focal cerebral ischemia-reperfusion injury via anti-inflammatory effects in rats.
2017,
Pubmed
Baron,
Treatment of acute ischemic stroke. Challenging the concept of a rigid and universal time window.
1995,
Pubmed
Buga,
Up-regulation of serotonin receptor 2B mRNA and protein in the peri-infarcted area of aged rats and stroke patients.
2016,
Pubmed
Chen,
The inhibitory effect of mesenchymal stem cell on blood-brain barrier disruption following intracerebral hemorrhage in rats: contribution of TSG-6.
2015,
Pubmed
Dalmaso,
Marine extremophiles: a source of hydrolases for biotechnological applications.
2015,
Pubmed
Davis,
Targeting antioxidant enzyme expression as a therapeutic strategy for ischemic stroke.
2017,
Pubmed
Dzialowski,
Brain tissue water uptake after middle cerebral artery occlusion assessed with CT.
2004,
Pubmed
Hill,
Transient middle cerebral artery occlusion with complete reperfusion in spontaneously hypertensive rats.
2014,
Pubmed
Keep,
Brain water content. A misunderstood measurement?
2012,
Pubmed
Longa,
Reversible middle cerebral artery occlusion without craniectomy in rats.
1989,
Pubmed
Martins,
Marketed marine natural products in the pharmaceutical and cosmeceutical industries: tips for success.
2014,
Pubmed
Mischenko,
Echinamines A and B, first aminated hydroxynaphthazarins from the sea urchin Scaphechinus mirabilis.
2005,
Pubmed
,
Echinobase
Mohamed,
Mechanisms of echinochrome potency in modulating diabetic complications in liver.
2016,
Pubmed
,
Echinobase
Schallert,
CNS plasticity and assessment of forelimb sensorimotor outcome in unilateral rat models of stroke, cortical ablation, parkinsonism and spinal cord injury.
2000,
Pubmed
Sokolova,
Effects of Carrageenans on Biological Properties of Echinochrome.
2018,
Pubmed
,
Echinobase
Stonik,
Development of medicines for hemorrhage stroke: the use of magnetic resonance tomography for estimating the effectiveness of histochrome.
2005,
Pubmed
Strubakos,
Non-invasive treatment with near-infrared light: A novel mechanisms-based strategy that evokes sustained reduction in brain injury after stroke.
2020,
Pubmed
Sun,
Free Radical Damage in Ischemia-Reperfusion Injury: An Obstacle in Acute Ischemic Stroke after Revascularization Therapy.
2018,
Pubmed
Sun,
Signaling pathway of MAPK/ERK in cell proliferation, differentiation, migration, senescence and apoptosis.
2015,
Pubmed
Tian,
Upregulation of DAPK contributes to homocysteine-induced endothelial apoptosis via the modulation of Bcl2/Bax and activation of caspase 3.
2016,
Pubmed
Trueman,
Systematic and detailed analysis of behavioural tests in the rat middle cerebral artery occlusion model of stroke: Tests for long-term assessment.
2017,
Pubmed
Tsujimoto,
Cell death regulation by the Bcl-2 protein family in the mitochondria.
2003,
Pubmed
Wurzelmann,
Therapeutic potential of brain-derived neurotrophic factor (BDNF) and a small molecular mimics of BDNF for traumatic brain injury.
2017,
Pubmed
Yu,
Proliferation, survival and metabolism: the role of PI3K/AKT/mTOR signalling in pluripotency and cell fate determination.
2016,
Pubmed
Yu,
Effect of ultrasonic treatment on the degradation and inhibition cancer cell lines of polysaccharides from Porphyra yezoensis.
2015,
Pubmed
Zhang,
Interleukin-11 treatment protected against cerebral ischemia/reperfusion injury.
2019,
Pubmed
Zhu,
Stroke Research in China over the Past Decade: Analysis of NSFC Funding.
2015,
Pubmed
