Click
here to close Hello! We notice that
you are using Internet Explorer, which is not supported by Echinobase
and may cause the site to display incorrectly. We suggest using a
current version of Chrome,
FireFox,
or Safari.
Mar Drugs
2019 Aug 05;178:. doi: 10.3390/md17080458.
Show Gene links
Show Anatomy links
Possibilities of Fucoidan Utilization in the Development of Pharmaceutical Dosage Forms.
Citkowska A
,
Szekalska M
,
Winnicka K
.
???displayArticle.abstract???
Fucoidan is a polysaccharide built from L-fucose molecules. The main source of this polysaccharide is the extracellular matrix of brown seaweed (Phaeophyta), but it can be also isolated from invertebrates such as sea urchins (Echinoidea) and sea cucumbers (Holothuroidea). Interest in fucoidan is related to its broad biological activity, including possible antioxidant, anti-inflammatory, antifungal, antiviral or antithrombotic effects. The potential application of fucoidan in the pharmaceutical technology is also due to its ionic nature. The negative charge of the molecule results from the presence of sulfate residues in the C-2 and C-4 positions, occasionally in C-3, allowing the formation of complexes with other oppositely charged molecules. Fucoidan is non-toxic, biodegradable and biocompatible compound approved by Food and Drug Administration (FDA) as Generally Recognized As Safe (GRAS) category as food ingredient. Fucoidan plays an important role in the pharmaceutical technology, so in this work aspects concerning its pharmaceutical characteristics and designing of various dosage forms (nanoparticles, liposomes, microparticles, and semisolid formulations) with fucoidan itself and with its combinations with other polymers or components that give a positive charge were reviewed. Advantages and limitations of fucoidan utilization in the pharmaceutical technology were also discussed.
Figure 1. Scheme of the fucoidan structure; R- carbohydrate substituents: xylose, arabinose, rhamnose, glucose, galactose, or uronic acid and non-carbohydrate substituents: sulfate or acetate residues.
Figure 2. Schematic presentation of pharmaceutical dosage forms designed with fucoidan utilization.
Figure 3. Scanning electron microscope (SEM) pictures of fucospheres: (a) magnification ×5000; (b) magnification ×20,000.
Abe,
Safety evaluation of excessive ingestion of mozuku fucoidan in human.
2013, Pubmed
Abe,
Safety evaluation of excessive ingestion of mozuku fucoidan in human.
2013,
Pubmed
Allen,
Liposomal drug delivery systems: from concept to clinical applications.
2013,
Pubmed
Barbosa,
Development of methotrexate loaded fucoidan/chitosan nanoparticles with anti-inflammatory potential and enhanced skin permeation.
2019,
Pubmed
Cai,
Primary biocompatibility tests of poly(lactide-co-glycolide)-(poly-L-orithine/fucoidan) core-shell nanocarriers.
2018,
Pubmed
Cardoso,
Marine Origin Polysaccharides in Drug Delivery Systems.
2016,
Pubmed
Chen,
Mutlifunctional nanoparticles prepared from arginine-modified chitosan and thiolated fucoidan for oral delivery of hydrophobic and hydrophilic drugs.
2018,
Pubmed
Chollet,
Fucoidans in Nanomedicine.
2016,
Pubmed
,
Echinobase
Chung,
Toxicological evaluation of fucoidan from Undaria pinnatifidain vitro and in vivo.
2010,
Pubmed
Cunha,
Inhalable Fucoidan Microparticles Combining Two Antitubercular Drugs with Potential Application in Pulmonary Tuberculosis Therapy.
2018,
Pubmed
Cunha,
Spray-dried fucoidan microparticles for pulmonary delivery of antitubercular drugs.
2018,
Pubmed
Cunha,
Sulfated Seaweed Polysaccharides as Multifunctional Materials in Drug Delivery Applications.
2016,
Pubmed
Dantas-Santos,
Antiproliferative activity of fucan nanogel.
2012,
Pubmed
da Silva,
Preparation and characterization of polysaccharide-based nanoparticles with anticoagulant activity.
2012,
Pubmed
Fernando,
A fucoidan fraction purified from Chnoospora minima; a potential inhibitor of LPS-induced inflammatory responses.
2017,
Pubmed
Fitton,
Therapies from Fucoidan: An Update.
2015,
Pubmed
,
Echinobase
Garcia-Vaquero,
Polysaccharides from macroalgae: Recent advances, innovative technologies and challenges in extraction and purification.
2017,
Pubmed
Gideon,
Toxicological evaluation of fucoidan from Cladosiphon okamuranus.
2008,
Pubmed
Hifney,
Upgrading the antioxidant properties of fucoidan and alginate from Cystoseira trinodis by fungal fermentation or enzymatic pretreatment of the seaweed biomass.
2018,
Pubmed
Hsu,
Clinical applications of fucoidan in translational medicine for adjuvant cancer therapy.
2019,
Pubmed
Huang,
Effect of basic fibroblast growth factor released from chitosan-fucoidan nanoparticles on neurite extension.
2016,
Pubmed
Huang,
Preparation and characterization of antioxidant nanoparticles composed of chitosan and fucoidan for antibiotics delivery.
2014,
Pubmed
Huang,
Biphasic release of gentamicin from chitosan/fucoidan nanoparticles for pulmonary delivery.
2016,
Pubmed
Hwang,
Fabrication and Cytotoxicity of Fucoidan-Cisplatin Nanoparticles for Macrophage and Tumor Cells.
2017,
Pubmed
Hwang,
Toxicological Evaluation of Low Molecular Weight Fucoidan in Vitro and in Vivo.
2016,
Pubmed
Jang,
Fucoidan-coated CuS nanoparticles for chemo-and photothermal therapy against cancer.
2018,
Pubmed
Jiao,
Chemical structures and bioactivities of sulfated polysaccharides from marine algae.
2011,
Pubmed
Juenet,
Thrombolytic therapy based on fucoidan-functionalized polymer nanoparticles targeting P-selectin.
2018,
Pubmed
Kim,
Genotoxicity studies on fucoidan from Sporophyll of Undaria pinnatifida.
2010,
Pubmed
Kim,
Doxorubicin-fucoidan-gold nanoparticles composite for dual-chemo-photothermal treatment on eye tumors.
2017,
Pubmed
Kimura,
Cytotoxic effects of fucoidan nanoparticles against osteosarcoma.
2013,
Pubmed
Lee,
Synergistic effect of fucoidan with antibiotics against oral pathogenic bacteria.
2013,
Pubmed
Lee,
Doxorubicin loading fucoidan acetate nanoparticles for immune and chemotherapy in cancer treatment.
2013,
Pubmed
Li,
Development of Polymer Microcapsules Functionalized with Fucoidan to Target P-Selectin Overexpressed in Cardiovascular Diseases.
2017,
Pubmed
Li,
Toxicological evaluation of fucoidan extracted from Laminaria japonica in Wistar rats.
2005,
Pubmed
Lira,
Cytotoxicity and cellular uptake of newly synthesized fucoidan-coated nanoparticles.
2011,
Pubmed
Lu,
Development of a new type of multifunctional fucoidan-based nanoparticles for anticancer drug delivery.
2017,
Pubmed
Mansour,
Primary structure and anticoagulant activity of fucoidan from the sea cucumber Holothuria polii.
2019,
Pubmed
,
Echinobase
Murakami,
Hydrogel blends of chitin/chitosan, fucoidan and alginate as healing-impaired wound dressings.
2010,
Pubmed
Murakami,
Enhanced healing of mitomycin C-treated healing-impaired wounds in rats with hydrosheets composed of chitin/chitosan, fucoidan, and alginate as wound dressings.
2010,
Pubmed
Myers,
Effects of fucoidan from Fucus vesiculosus in reducing symptoms of osteoarthritis: a randomized placebo-controlled trial.
2016,
Pubmed
Myers,
A combined phase I and II open label study on the effects of a seaweed extract nutrient complex on osteoarthritis.
2010,
Pubmed
Nakamura,
Effect of controlled release of fibroblast growth factor-2 from chitosan/fucoidan micro complex-hydrogel on in vitro and in vivo vascularization.
2008,
Pubmed
Park,
Fucoidan improves the structural integrity and the molecular stability of β-lactoglobulin.
2018,
Pubmed
Pawar,
Improved chemotherapy against breast cancer through immunotherapeutic activity of fucoidan decorated electrostatically assembled nanoparticles bearing doxorubicin.
2019,
Pubmed
Pinheiro,
Chitosan/fucoidan multilayer nanocapsules as a vehicle for controlled release of bioactive compounds.
2015,
Pubmed
Prasad,
Efficacy and safety of a new-class hemostatic drug candidate, AV513, in dogs with hemophilia A.
2008,
Pubmed
Purnama,
Fucoidan in a 3D scaffold interacts with vascular endothelial growth factor and promotes neovascularization in mice.
2015,
Pubmed
S,
Fucoidan coated ciprofloxacin loaded chitosan nanoparticles for the treatment of intracellular and biofilm infections of Salmonella.
2017,
Pubmed
Sanjeewa,
The potential of brown-algae polysaccharides for the development of anticancer agents: An update on anticancer effects reported for fucoidan and laminaran.
2017,
Pubmed
Sezer,
Fucosphere--new microsphere carriers for peptide and protein delivery: preparation and in vitro characterization.
2006,
Pubmed
Sezer,
The design of biodegradable ofloxacin-based core-shell microspheres: influence of the formulation parameters on in vitro characterization.
2012,
Pubmed
Sezer,
The use of fucosphere in the treatment of dermal burns in rabbits.
2008,
Pubmed
Sezer,
Comparison on in vitro characterization of fucospheres and chitosan microspheres encapsulated plasmid DNA (pGM-CSF): formulation design and release characteristics.
2009,
Pubmed
Sezer,
Preparation of fucoidan-chitosan hydrogel and its application as burn healing accelerator on rabbits.
2008,
Pubmed
Song,
Genotoxicity testing of low molecular weight fucoidan from brown seaweeds.
2012,
Pubmed
Tocaciu,
The Effect of Undaria pinnatifida Fucoidan on the Pharmacokinetics of Letrozole and Tamoxifen in Patients With Breast Cancer.
2018,
Pubmed
Tsai,
Efficacy of Low-Molecular-Weight Fucoidan as a Supplemental Therapy in Metastatic Colorectal Cancer Patients: A Double-Blind Randomized Controlled Trial.
2017,
Pubmed
Tsai,
Development of mutlifunctional nanoparticles self-assembled from trimethyl chitosan and fucoidan for enhanced oral delivery of insulin.
2019,
Pubmed
Venkatesan,
Preparation, Characterization and Biological Applications of Biosynthesized Silver Nanoparticles with Chitosan-Fucoidan Coating.
2018,
Pubmed
Wang,
Poly-allylamine hydrochloride and fucoidan-based self-assembled polyelectrolyte complex nanoparticles for cancer therapeutics.
2019,
Pubmed
Wang,
Poly-L-ornithine/fucoidan-coated calcium carbonate microparticles by layer-by-layer self-assembly technique for cancer theranostics.
2018,
Pubmed
Wu,
A review about the development of fucoidan in antitumor activity: Progress and challenges.
2016,
Pubmed
Zayed,
Fucoidan production: Approval key challenges and opportunities.
2019,
Pubmed
Zhao,
Bioactivity of fucoidan extracted from Laminaria japonica using a novel procedure with high yield.
2018,
Pubmed
