ECB-ART-47058
Mater Sci Eng C Mater Biol Appl
2019 Jun 01;99:171-179. doi: 10.1016/j.msec.2019.01.118.
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In vivo evaluation of thiol-functionalized superparamagnetic iron oxide nanoparticles.
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This article describes the synthesis, characterization and in vivo cytotoxic evaluation of thiol-functionalized superparamagnetic iron oxide magnetic nanoparticles (SPIONs). They have been employed as potential vehicles for a large number of biomedical applications, such as drug delivery. Fe3O4 nanoparticles were synthesized by coprecipitation of iron salts and coated with L-cysteine. The physicochemical, morphological, and magnetic properties of Cys-Fe3O4 nanoparticles were characterized by different experimental techniques. To evaluate their applicability in nanomedicine we evaluated their cytotoxicity using Balb/C mice. The results show that Cys-SPIONs are good candidates as nanocarriers in biomedical applications.
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Genes referenced: LOC115925415