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J Am Soc Mass Spectrom
2019 May 01;305:743-764. doi: 10.1007/s13361-019-02136-3.
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Structural Characterization of Polar Steroid Compounds of the Far Eastern Starfish Lethasterias fusca by Nanoflow Liquid Chromatography Coupled to Quadrupole Time-of-Flight Tandem Mass Spectrometry.
Popov RS
,
Ivanchina NV
,
Kicha AA
,
Malyarenko TV
,
Dmitrenok PS
.
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Nanoflow liquid chromatography coupled with a captive spray ionization time-of-flight tandem mass spectrometer (nLC/CSI-QTOF-MS/MS) was used in the structural determination of polar steroid compounds of starfish Lethasterias fusca. A total of 207 compounds including 106 asterosaponins, 81 glycosides of polyhydroxysteroids, and 14 polyhydroxylated steroids were detected and characterized by MS and MS/MS. Twenty compounds among them were unambiguously identified using authentic standard compounds, isolated earlier from this and other starfish species. The other compounds were tentatively characterized by accurate mass measurement and comparing retention times and characteristic MS/MS fragmentation patterns with reference standards. Moreover, fragmentation behaviors of a series of pure standards of starfish polar steroids and polyhydroxysteroid compounds detected in L. fusca have been extensively investigated and characteristic fragmentation pathways were described and used for the characterization of unknown compounds.
Dong,
Chemical constituents and bioactivities of starfish.
2011, Pubmed,
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Dong,
Chemical constituents and bioactivities of starfish.
2011,
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,
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Gonçalves,
ESI-MS differential fragmentation of positional isomers of sulfated oligosaccharides derived from carrageenans and agarans.
2010,
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Griffiths,
Tandem mass spectrometry in the study of fatty acids, bile acids, and steroids.
2003,
Pubmed
Hsu,
Elucidation of the double-bond position of long-chain unsaturated fatty acids by multiple-stage linear ion-trap mass spectrometry with electrospray ionization.
2008,
Pubmed
Huo,
Fragmentation investigation of brassinosteroid compounds by ion trap and quadrupole time-of-flight mass spectrometry.
2010,
Pubmed
Ivanchina,
Biosynthesis of polar steroids from the Far Eastern starfish Patiria (=Asterina) pectinifera. Cholesterol and cholesterol sulfate are converted into polyhydroxylated sterols and monoglycoside asterosaponin P1 in feeding experiments.
2013,
Pubmed
,
Echinobase
Ivanchina,
New steroid glycosides from the starfish Asterias rathbuni.
2001,
Pubmed
,
Echinobase
Ivanchina,
Steroid glycosides from marine organisms.
2011,
Pubmed
Ivanchina,
Two new asterosaponins from the Far Eastern starfish Lethasterias fusca.
2012,
Pubmed
,
Echinobase
Ivanchina,
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2015,
Pubmed
,
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Ivanchina,
Granulatosides D, E and other polar steroid compounds from the starfish Choriaster granulatus. Their immunomodulatory activity and cytotoxicity.
2019,
Pubmed
,
Echinobase
Ivanchina,
Hemolytic polar steroidal constituents of the starfish Aphelasterias japonica.
2000,
Pubmed
,
Echinobase
Jones,
Electron-induced dissociation (EID) for structure characterization of glycerophosphatidylcholine: determination of double-bond positions and localization of acyl chains.
2015,
Pubmed
Kicha,
Steroidal monoglycosides from the Far Eastern starfish Hippasteria kurilensis and hypothetic pathways of polyhydroxysteroid biosynthesis in starfish.
2009,
Pubmed
,
Echinobase
Kicha,
Steroidal triglycosides, kurilensosides A, B, and C, and other polar steroids from the Far Eastern starfish Hippasteria kurilensis.
2008,
Pubmed
,
Echinobase
Kicha,
The distribution of free sterols, polyhydroxysteroids and steroid glycosides in various body components of the starfish Patiria (=Asterina) pectinifera.
2001,
Pubmed
,
Echinobase
Malyarenko,
Asterosaponins from the Far Eastern starfish Leptasterias ochotensis and their anticancer activity.
2014,
Pubmed
,
Echinobase
Malyarenko,
Four New Sulfated Polar Steroids from the Far Eastern Starfish Leptasterias ochotensis: Structures and Activities.
2015,
Pubmed
,
Echinobase
Minale,
Steroidal oligoglycosides and polyhydroxysteroids from echinoderms.
1993,
Pubmed
Minamisawa,
Fragmentations of isomeric sulfated monosaccharides using electrospray ion trap mass spectrometry.
2005,
Pubmed
Sandvoss,
Combination of matrix solid-phase dispersion extraction and direct on-line liquid chromatography-nuclear magnetic resonance spectroscopy-tandem mass spectrometry as a new efficient approach for the rapid screening of natural products: application to the total asterosaponin fraction of the starfish Asterias rubens.
2001,
Pubmed
,
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