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Metab Brain Dis
2019 Jun 01;343:705-713. doi: 10.1007/s11011-019-0386-8.
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Evaluation of neuroglobin and cytoglobin expression in adult rats exposed to silver nanoparticles during prepubescence.
da Conceição RR
,
de Souza JS
,
de Oliveira KC
,
Romano RM
,
de Barros Maciel RM
,
Dias-da-Silva MR
,
Romano MA
,
Chiamolera MI
,
Giannocco G
.
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Silver nanoparticles (AgNPs) are clusters of silver atoms with diameters that range from 1 to 100 nm. Due to the various shapes and large surface areas, AgNPs have been employed in the food and textile industries and medical fields. Therefore, because of the widespread use of these compounds, the aim of this study was to evaluate the effect of AgNP exposure on the gene and protein expression levels of Neuroglobin (Ngb) and Cytoglobin (Cygb), in the rat cortex, hippocampus and cerebellum. Post-natal day (PND) 21 male Wistar rats were randomly divided into three groups. One group received 15 μg/kg body weight of AgNP by gavage another group received 30 μg/kg and the control group that received saline, from PND23 to PND58. On PND102 the animals were euthanized and the cortex, hippocampus and cerebellum were isolated and evaluated for gene and protein expression levels of Nbg and Cygb. The results demonstrated that the 30 μg/kg AgNP group displayed increased gene and protein expression of Cygb in the cortex. In the Hippocampus, AgNP exposure did not modulate gene or protein expression levels of Ngb and Cygb. In cerebellum the Ngb gene and protein expression was increased with both doses of AgNP. AgNP exposure during prepubescence can modulate the gene and protein expression levels of Ngb and Cygb in adulthood. Furthermore, the observed modulation was specific to the cerebellum, and cortex, and was dose dependent.
Ahmed,
Thyroid hormones states and brain development interactions.
2008, Pubmed
Ahmed,
Thyroid hormones states and brain development interactions.
2008,
Pubmed
Amiri,
Maternal exposure to silver nanoparticles are associated with behavioral abnormalities in adulthood: Role of mitochondria and innate immunity in developmental toxicity.
2018,
Pubmed
Antao,
Neuroglobin overexpression in cultured human neuronal cells protects against hydrogen peroxide insult via activating phosphoinositide-3 kinase and opening the mitochondrial K(ATP) channel.
2010,
Pubmed
Bradford,
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.
1976,
Pubmed
Brunori,
Neuroglobin, seven years after.
2007,
Pubmed
Burmester,
Neuroglobin and cytoglobin: genes, proteins and evolution.
2004,
Pubmed
Burmester,
Regulation and role of neuroglobin and cytoglobin under hypoxia.
2007,
Pubmed
Burmester,
Cytoglobin: a novel globin type ubiquitously expressed in vertebrate tissues.
2002,
Pubmed
Cai,
TAT-mediated delivery of neuroglobin protects against focal cerebral ischemia in mice.
2011,
Pubmed
Cardinale,
Localization of neuroglobin in the brain of R6/2 mouse model of Huntington's disease.
2018,
Pubmed
Dan,
Silver Nanoparticle Exposure Induces Neurotoxicity in the Rat Hippocampus Without Increasing the Blood-Brain Barrier Permeability.
2018,
Pubmed
Dos Santos,
Silver nanoparticles: therapeutical uses, toxicity, and safety issues.
2014,
Pubmed
Dussault,
Rapid and simple comparison of messenger RNA levels using real-time PCR.
2006,
Pubmed
Dziendzikowska,
Time-dependent biodistribution and excretion of silver nanoparticles in male Wistar rats.
2012,
Pubmed
Dąbrowska-Bouta,
Prolonged Exposure to Silver Nanoparticles Results in Oxidative Stress in Cerebral Myelin.
2019,
Pubmed
Fathi,
The effect of silver nanoparticles on the reproductive system of adult male rats: A morphological, histological and DNA integrity study.
2019,
Pubmed
Fordel,
Hypoxia/ischemia and the regulation of neuroglobin and cytoglobin expression.
2004,
Pubmed
Fordel,
Neuroglobin and cytoglobin overexpression protects human SH-SY5Y neuroblastoma cells against oxidative stress-induced cell death.
2006,
Pubmed
Fordel,
Neuroglobin and cytoglobin expression in mice. Evidence for a correlation with reactive oxygen species scavenging.
2007,
Pubmed
Gonzalez-Carter,
Silver nanoparticles reduce brain inflammation and related neurotoxicity through induction of H2S-synthesizing enzymes.
2017,
Pubmed
Greenberg,
Neuroglobin: an endogenous neuroprotectant.
2008,
Pubmed
Guo,
Characterization of human cytoglobin gene promoter region.
2006,
Pubmed
Hu,
Ulinastatin attenuates oxidation, inflammation and neural apoptosis in the cerebral cortex of adult rats with ventricular fibrillation after cardiopulmonary resuscitation.
2013,
Pubmed
Huang,
Silver nanoparticles affect on gene expression of inflammatory and neurodegenerative responses in mouse brain neural cells.
2015,
Pubmed
Hundahl,
Anatomical characterization of cytoglobin and neuroglobin mRNA and protein expression in the mouse brain.
2010,
Pubmed
Hundahl,
Neuroglobin and cytoglobin expression in the human brain.
2013,
Pubmed
Hussain,
In vitro toxicity of nanoparticles in BRL 3A rat liver cells.
2005,
Pubmed
Juan,
Deposition of silver nanoparticles on titanium surface for antibacterial effect.
2010,
Pubmed
Khan,
Neuroglobin-overexpressing transgenic mice are resistant to cerebral and myocardial ischemia.
2006,
Pubmed
Kim,
Antimicrobial effects of silver nanoparticles.
2007,
Pubmed
Krawczyńska,
Silver and titanium dioxide nanoparticles alter oxidative/inflammatory response and renin-angiotensin system in brain.
2015,
Pubmed
Lankveld,
The kinetics of the tissue distribution of silver nanoparticles of different sizes.
2010,
Pubmed
Li,
The activity of recombinant human neuroglobin as an antioxidant and free radical scavenger.
2011,
Pubmed
Loeschner,
Distribution of silver in rats following 28 days of repeated oral exposure to silver nanoparticles or silver acetate.
2011,
Pubmed
Maglione,
Impact of swimming exercise on inflammation in medullary areas of sympathetic outflow control in spontaneously hypertensive rats.
2018,
Pubmed
Martin,
Accumulation of Silver in Yellow Perch ( Perca flavescens) and Northern Pike ( Esox lucius) From a Lake Dosed with Nanosilver.
2018,
Pubmed
Mathias,
Daily exposure to silver nanoparticles during prepubertal development decreases adult sperm and reproductive parameters.
2015,
Pubmed
Moens,
Globins in the brain.
2000,
Pubmed
Oleksiewicz,
Cytoglobin: biochemical, functional and clinical perspective of the newest member of the globin family.
2011,
Pubmed
Oliveira,
Thyroid hormone modulates neuroglobin and cytoglobin in rat brain.
2015,
Pubmed
,
Echinobase
Ou,
Recombinant Human Cytoglobin Prevents Atherosclerosis by Regulating Lipid Metabolism and Oxidative Stress.
2018,
Pubmed
Quadros,
Environmental and human health risks of aerosolized silver nanoparticles.
2010,
Pubmed
Rahman,
Expression of genes related to oxidative stress in the mouse brain after exposure to silver-25 nanoparticles.
2009,
Pubmed
Renis,
Nuclear DNA strand breaks during ethanol-induced oxidative stress in rat brain.
1996,
Pubmed
Salomoni,
Antibacterial effect of silver nanoparticles in Pseudomonas aeruginosa.
2017,
Pubmed
Skalska,
Oxidative stress in rat brain but not in liver following oral administration of a low dose of nanoparticulate silver.
2016,
Pubmed
Sun,
Neuroglobin is up-regulated by and protects neurons from hypoxic-ischemic injury.
2001,
Pubmed
Sun,
Neuroglobin protects the brain from experimental stroke in vivo.
2003,
Pubmed
Tae,
Evaluation of globins expression in brain, heart, and lung in rats exposed to side stream cigarette smoke.
2017,
Pubmed
,
Echinobase
Ter-Minassian,
[Cerebral metabolism and brain injury].
2006,
Pubmed
Van Acker,
Neuroglobin Expression in the Brain: a Story of Tissue Homeostasis Preservation.
2019,
Pubmed
Vazquez-Garcia,
Effect of Silver Nanoparticles on Physicochemical and Antibacterial Properties of Calcium Silicate Cements.
2016,
Pubmed
Wright,
Efficacy of topical silver against fungal burn wound pathogens.
1999,
Pubmed
Xu,
Neurotoxicity of Silver Nanoparticles in Rat Brain After Intragastric Exposure.
2015,
Pubmed
Yu,
Silver nanoparticles in the environment.
2013,
Pubmed
da Conceição,
Anatomical specificity of the brain in the modulation of Neuroglobin and Cytoglobin genes after chronic bisphenol a exposure.
2017,
Pubmed
,
Echinobase
van der Zande,
Distribution, elimination, and toxicity of silver nanoparticles and silver ions in rats after 28-day oral exposure.
2012,
Pubmed