Click
here to close Hello! We notice that
you are using Internet Explorer, which is not supported by Echinobase
and may cause the site to display incorrectly. We suggest using a
current version of Chrome,
FireFox,
or Safari.
Mar Drugs
2019 Jan 04;171:. doi: 10.3390/md17010026.
Show Gene links
Show Anatomy links
Capillasterin A, a Novel Pyrano[2,3-f]chromene from the Australian Crinoid Capillaster multiradiatus.
Lum KY
,
Carroll AR
,
Ekins MG
,
Read S
,
Haq Z
,
Tietjen I
,
St John J
,
Davis RA
.
???displayArticle.abstract???
Capillasterin A (1), a novel pyrano[2,3-f]chromene, together with seven known naphthopyrones including comaparvin (2), TMC-256C1 (3), 6-methoxycomaparvin-5- methyl ether (4), 5,8-dihydroxy-6-methoxy-2-propyl-4H-naphtho[2,3-b]pyran-4-one (5), 5,8-dihydroxy-6,10-dimethoxy-2-propyl-4H-naphtho[2,3-b]pyran-4-one (6), TMC-256A1 (7) and 6-methoxycomaparvin (8) were isolated from an EtOH/H₂O extract from the Australian crinoid Capillaster multiradiatus. The structures of all the compounds were determined by detailed spectroscopic (1D/2D NMR and MS) data analysis. This is the first report of a natural product that contains the pyrano[2,3-f]chromene skeleton. Compounds 2⁻6 were observed to display moderate inhibition of in vitro HIV-1 replication in a T cell line with EC50 values ranging from 7.5 to 25.5 µM without concomitant cytotoxicity.
Adachi,
Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone.
1986, Pubmed
Adachi,
Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone.
1986,
Pubmed
Bokesch,
Inhibition of ABCG2-mediated drug efflux by naphthopyrones from marine crinoids.
2010,
Pubmed
,
Echinobase
Brockman,
Use of a novel GFP reporter cell line to examine replication capacity of CXCR4- and CCR5-tropic HIV-1 by flow cytometry.
2006,
Pubmed
Chen,
The serrulatane diterpenoid natural products RAD288 and RAD289 stimulate properties of olfactory ensheathing cells useful for neural repair therapies.
2018,
Pubmed
Chen,
Anti-inflammatory and analgesic effects of the marine-derived compound comaparvin isolated from the crinoid Comanthus bennetti.
2014,
Pubmed
,
Echinobase
Chovolou,
Identification of angular naphthopyrones from the Philippine echinoderm Comanthus species as inhibitors of the NF-κB signaling pathway.
2011,
Pubmed
,
Echinobase
Feng,
Crinoids: ancient organisms, modern chemistry.
2017,
Pubmed
FOLEY,
CONTINUOUS CULTURE OF HUMAN LYMPHOBLASTS FROM PERIPHERAL BLOOD OF A CHILD WITH ACUTE LEUKEMIA.
1965,
Pubmed
Folmer,
NF-kappaB-inhibiting naphthopyrones from the Fijian echinoderm Comanthus parvicirrus.
2008,
Pubmed
,
Echinobase
Frandsen,
The biosynthetic pathway for aurofusarin in Fusarium graminearum reveals a close link between the naphthoquinones and naphthopyrones.
2006,
Pubmed
Khokhar,
Rhodocomatulin-Type Anthraquinones from the Australian Marine Invertebrates Clathria hirsuta and Comatula rotalaria.
2016,
Pubmed
,
Echinobase
Levrier,
6α-Acetoxyanopterine: A Novel Structure Class of Mitotic Inhibitor Disrupting Microtubule Dynamics in Prostate Cancer Cells.
2017,
Pubmed
Richard,
Identification of Novel HIV-1 Latency-Reversing Agents from a Library of Marine Natural Products.
2018,
Pubmed
Sakurai,
TMC-256A1 and C1, new inhibitors of IL-4 signal transduction produced by Aspergillus niger var niger TC 1629.
2002,
Pubmed
Staunton,
Polyketide biosynthesis: a millennium review.
2001,
Pubmed
Summers,
Phylogeny of Comatulidae (Echinodermata: Crinoidea: Comatulida): a new classification and an assessment of morphological characters for crinoid taxonomy.
2014,
Pubmed
,
Echinobase
Tietjen,
Screening of the Pan-African natural product library identifies ixoratannin A-2 and boldine as novel HIV-1 inhibitors.
2015,
Pubmed
Tietjen,
Inhibition of NF-κB-dependent HIV-1 replication by the marine natural product bengamide A.
2018,
Pubmed
Vien,
Anthraquinone and Butenolide Constituents from the Crinoid Capillaster multiradiatus.
2018,
Pubmed
,
Echinobase
Wätjen,
Cytotoxic effects of the anthraquinone derivatives 1'-deoxyrhodoptilometrin and (S)-(-)-rhodoptilometrin isolated from the marine echinoderm Comanthus sp.
2017,
Pubmed
,
Echinobase
Wolkenstein,
Persistent and widespread occurrence of bioactive quinone pigments during post-Paleozoic crinoid diversification.
2015,
Pubmed
,
Echinobase
Zulfiqar,
Screening a Natural Product-Based Library against Kinetoplastid Parasites.
2017,
Pubmed