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Mar Drugs
2018 Dec 15;1612:. doi: 10.3390/md16120509.
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Antiviral and Antioxidant Properties of Echinochrome A.
Fedoreyev SA
,
Krylova NV
,
Mishchenko NP
,
Vasileva EA
,
Pislyagin EA
,
Iunikhina OV
,
Lavrov VF
,
Svitich OA
,
Ebralidze LK
,
Leonova GN
.
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The aim of this study was to examine the in vitro antioxidant and antiviral activities of echinochrome A and echinochrome-based antioxidant composition against tick-borne encephalitis virus (TBEV) and herpes simplex virus type 1 (HSV-1). The antioxidant composition, which is a mixture of echinochrome A, ascorbic acid, and α-tocopherol (5:5:1), showed higher antioxidant and antiviral effects than echinochrome A. We suppose that echinochrome A and its composition can both directly affect virus particles and indirectly enhance antioxidant defense mechanisms in the hosting cell. The obtained results allow considering the echinochrome A and the composition of antioxidants on its basis as the promising agents with the both antioxidant and antiviral activities.
Figure 1. Influence of Ech and studied formulations on the lipopolysaccharide (LPS)-induced reactive oxygen species (ROS) formations in Vero cells. The formulations were tested at a concentration of five μg/mL. * p < 0.05; ** statistically significant differences between Asc + Toc and Ech (p ≤ 0.05).
Figure 2. Antiviral action of the formulations on different stages of virus replication cycles. * Statistically significant differences between Asc + Toc and other formulation (p ≤ 0.05), ** statistically significant differences between antioxidant composition and Ech (p ≤ 0.05).
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